Immeasurable time bias in observational studies of drug effects on mortality

American Journal of Epidemiology

Volumn 168, Issue 3, 2008, Pages 329-335

  Suissa, Samy ^a,b,c  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c ROYAL VICTORIA HOSPITAL   (Canada)

Author keywords

Bias (epidemiology); Case control studies; Cohort studies; Databases as topic; Drug therapy; Misclassification; Treatment outcome

Indexed keywords

CORTICOSTEROID;

DATABASE; DISEASE TREATMENT; DRUG; HORMONE; MORTALITY; RESPIRATORY DISEASE; STEROID;

AGED; ARTICLE; CASE CONTROL STUDY; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLASSIFICATION; COHORT ANALYSIS; CONFIDENCE INTERVAL; CONTROLLED STUDY; DATA BASE; DEATH; DRUG EFFECT; DRUG EFFICACY; FEMALE; FOLLOW UP; HOSPITALIZATION; HUMAN; KAPLAN MEIER METHOD; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MEASUREMENT ERROR; MORTALITY; OBSERVATION; PRESCRIPTION; TIME;

ADMINISTRATION, INHALATION; ANTI-INFLAMMATORY AGENTS; BIAS (EPIDEMIOLOGY); CASE-CONTROL STUDIES; COHORT STUDIES; DATABASES, FACTUAL; GLUCOCORTICOIDS; HUMANS; ODDS RATIO; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RESEARCH DESIGN; SASKATCHEWAN; SURVIVAL ANALYSIS; TIME FACTORS; TREATMENT OUTCOME;

CANADA; NORTH AMERICA; SASKATCHEWAN;

EID: 47649092867     PISSN: 00029262     EISSN: 14766256     Source Type: Journal    
DOI: 10.1093/aje/kwn135     Document Type: Article

References (17)

1. Pharmacoepidemiology. Chichester, United Kingdom: John Wiley & Sons, Ltd, 2005.
2. Kiri VA, Pride NB, Soriano JB, et al. Inhaled corticosteroids in chronic obstructive pulmonary disease: results from two observational designs free of immortal time bias. Am J Respir Crit Care Med 2005;172:460-4.
3. Hippisley-Cox J, Coupland C. Effect of statins on the mortality of patients with ischaemic heart disease: population based cohort study with nested case-control analysis. Heart 2006;92:752-8.
4. Hippisley-Cox J, Coupland C. Effect of combinations of drugs on all cause mortality in patients with ischaemic heart disease: nested case-control analysis. BMJ 2005;330:1059-63.
5. Mancini GB, Etminan M, Zhang B, et al. Reduction of morbidity and mortality by statins, angiotensin-converting enzyme inhibitors, and angiotensin receptor blockers in patients with chronic obstructive pulmonary disease. J Am Coll Cardiol 2006;47:2554-60.
6. Ray JG, Gong Y, Sykora K, et al. Statin use and survival outcomes in elderly patients with heart failure. Arch Intern Med 2005;165:62-7.
7. Rochon PA, Sykora K, Bronskill SE, et al. Use of angiotensin-converting enzyme inhibitor therapy and dose-related outcomes in older adults with new heart failure in the community. J Gen Intern Med 2004;19:676-83.
8. Hackam DG, Mamdani M, Li P, et al. Statins and sepsis in patients with cardiovascular disease: a population-based cohort analysis. Lancet 2006;367:413-18.
9. Macie C, Wooldrage K, Manfreda J, et al. Inhaled corticosteroids and mortality in COPD. Chest 2006;130:640-6.
10. Bourbeau J, Ernst P, Cockcoft D, et al. Inhaled corticosteroids and hospitalisation due to exacerbation of COPD. Eur Respir J 2003;22:286-9.
11. Kalbfleisch JD, Prentice RL. The statistical analysis of failure time data. New York, NY: John Wiley & Sons, Ltd, 1980.
12. Poole C. Exposure opportunity in case-control studies. Am J Epidemiol 1986;123:352-8.
13. Schlesselman JJ, Stadel BV. Exposure opportunity in epidemiologic studies. Am J Epidemiol 1987;125:174-8.
14. Lyles RH, Allen AS, Dana FW, et al. Inference for case-control studies when exposure status is both informatively missing and misclassified. Stat Med 2006;25:4065-80.
15. Rice K. Full-likelihood approaches to misclassification of a binary exposure in matched case-control studies. Stat Med 2003;22:3177-94.
16. Li X, Song X, Gray RH. Comparison of the missing-indicator method and conditional logistic regression in 1:m matched case-control studies with missing exposure values. Am J Epidemiol 2004;159:603-10.
17. Epstein AM. The outcomes movement - will it get us where we want to go? N Engl J Med 1990;323:266-70.