Ginsenoside Rg1 inhabits cardiomyocyte hypertrophy induced by prostaglandin F2α

Chinese Pharmacological Bulletin

Volumn 24, Issue 5, 2008, Pages 611-615

  Wang, Ying Ting ^a   Huang, Xie Nan ^a   Wang, Feng An ^b  

^a ZUNYI MEDICAL UNIVERSITY   (China)

^b Jiaozuo People's Hospitl ^*  (China)

Author keywords

Cardic myocyte hypertrophy; Ginsenoside Rg1; Intracellular free calcium concentration; Nitric oxide; Prostaglandin F2

Indexed keywords

ATRIAL NATRIURETIC FACTOR; CALCIUM; FURA 2 ACETOXYMETHYL ESTER; GINSENOSIDE RG 1; MESSENGER RNA; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; PROSTAGLANDIN F2 ALPHA;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CELL SIZE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; GENE EXPRESSION; HEART VENTRICLE HYPERTROPHY; NONHUMAN; PROTEIN CONTENT; RAT; REAL TIME POLYMERASE CHAIN REACTION;

EID: 47649091061     PISSN: 10011978     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Frey N, Mckinsey T A, Olson E N. Decoding calcium signals involved in cardiac growth and function [J]. Nat Med, 2000, 6(11):1221-7.
2. Kudoh S, Akazawa H, Takano H, et al. Stretch modulation of second messengers: effects on cardiomyocyte ion transport [J]. Prog Biophys Mol Biol, 2003, 82:57-66.
3. 2+-calcineurin-NFAT casecade in cardiac myocytes [J]. Cardiovase Res, 2004, 63(3):450-7.
4. Wollert K C, Drexler H. Regulation of cardiac remodeling by nitric oxide: focus on cardiac myocytes hypertrophy and apoptosis [J]. Heart Fail Rev, 2002, 7(4):317-25.
5. 2α induces cardiac myocyte hypertrophy in vutro and cardiac growth in vivo [J]. Am J Physiol, 1996, 271:2197-208.
6. 2 alpha stimulates hypertrophic growth of cultured neonatal rat ventricular myocytes [J]. J Biol Chem, 1996, 271(2):1179-86.
7. Jiang Q S, Huang X N, Dai Z K, et al. Inhibitory effect of ginsenoside Rb1 on cardiac hypertrophy induced by monocrotaline in rat [J]. Ethnopharmacol, 2007, 111(3):567-72.
8. Chinese source
9. E Z. Tissue culture and molecular cytology technology [M]. 2nd edition, Beijing: Beijing Publishing House, 1997:131-2
10. Taigen T, De Windt J J, Molkentin J D. Targeted inhibition of calcineurin prevents agonist-induced cardiomyocyte hypertrophy [J]. Proc Natl Acad Sci USA, 2000, 97(3):1196-201.
11. Abassi Z, Brodsky S, Gealekman O, et al. Intrarenal expression and distribution of cyclooxygenase isoforms in rats with experimental heart failure [J]. Am J Physiol Renal Physiol, 2001, 280(1):43-53.
12. Chinese source
13. Xu S Y, Bian R L, Chen X. Pharmacological experimental methodology [M]. 3th edition, Beijing: People's Medical Publishing House, 2002:106-30.
14. Krishnan P, Ventura HO, Uber PA et al. Treatment of hypertension for patients with diastolic dysfunction [J]. Curr Opin Cardiol, 2003, 18(4):272-7.
15. Chinese source
16. Wang Y S, Deng W L, Xue C S. Chinese traditional medicine pharmacology and application [M]. 2nd edition, Beijing; People's Medical Publishing House, 1998:12.
17. Chinese source
18. 25-35 [J]. Chin Pharmacol Bull, 2007, 15(5):612-7.
19. 2α may be mediated by calcineurin signal transduction pathway in rats [J]. Acta Physiol Sin, 2005, 57(6):742-8.
20. Molkentin J D, Dorn II G W. Cytoplasmic signaling pathways that regulate cardiac hypertrophy [J]. Annu Rev Physiol, 2001, 63:391-426.
21. Molkentin J D, Lu J R, Antos C L, et al. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy [J]. Cell, 1998, 93(2):215-28.