Early childhood infection by human herpesvirus 8 in Zambia and the role of human immunodeficiency virus type 1 coinfection in a highly endemic area

American Journal of Epidemiology

Volumn 168, Issue 3, 2008, Pages 311-320

  Minhas, Veenu ^a   Crabtree, Kay L ^a   Chao, Ann ^b   M'soka, Tendai J ^c   Kankasa, Chipepo ^c   Bulterys, Marc ^b,d   Mitchell, Charles D ^e   Wood, Charles ^a,f  

^a UNIVERSITY OF NEBRASKA   (United States)

^b CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^c UNIVERSITY TEACHING HOSPITAL   (Zambia)

^d CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^e UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF NEBRASKA LINCOLN   (United States)

Author keywords

Herpesvirus 8, human; HIV 1; Infection; Sarcoma, Kaposi; Zambia

Indexed keywords

VIRUS ANTIBODY;

ANTIBODY; CANCER; CHILD HEALTH; COHORT ANALYSIS; DISEASE INCIDENCE; DISEASE TRANSMISSION; HEALTH STATUS; HOMINID; HUMAN IMMUNODEFICIENCY VIRUS; SKIN DISORDER;

ANTIBODY TITER; ARTICLE; CHILDHOOD DISEASE; COHORT ANALYSIS; CONFIDENCE INTERVAL; CONTROLLED STUDY; ENDEMIC DISEASE; FEMALE; FOLLOW UP; HAZARD ASSESSMENT; HAZARD RATIO; HERPES VIRUS INFECTION; HUMAN; HUMAN HERPESVIRUS 8; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; MALE; MIXED INFECTION; MOTHER CHILD RELATION; PRESCHOOL CHILD; PROSPECTIVE STUDY; SEROCONVERSION; SEROPREVALENCE; VIRUS TRANSMISSION; ZAMBIA;

ADULT; CHILD, PRESCHOOL; COHORT STUDIES; CROSS-SECTIONAL STUDIES; DISEASE TRANSMISSION, HORIZONTAL; DISEASE TRANSMISSION, VERTICAL; ENDEMIC DISEASES; FEMALE; HERPESVIRIDAE INFECTIONS; HERPESVIRUS 8, HUMAN; HIV INFECTIONS; HIV SEROPREVALENCE; HIV-1; HUMANS; INCIDENCE; INFANT; INFANT, NEWBORN; MALE; PREGNANCY; PROSPECTIVE STUDIES; RISK FACTORS; SEROEPIDEMIOLOGIC STUDIES; ZAMBIA;

AFRICA; LUSAKA [ZAMBIA]; SOUTHERN AFRICA; SUB-SAHARAN AFRICA; ZAMBIA;

HUMAN HERPESVIRUS 8; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 47649087464     PISSN: 00029262     EISSN: 14766256     Source Type: Journal    
DOI: 10.1093/aje/kwn125     Document Type: Article

References (54)

1. Cesarman E, Chang Y, Moore PS, et al. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. N Engl J Med 1995;332:1186-91.
2. Chang Y, Cesarman E, Pessin MS, et al. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science 1994;266:1865-9.
3. Schulz TF. Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8). J Gen Virol 1998;79:1573-91.
4. Soulier J, Grollet L, Oksenhendler E, et al. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease. Blood 1995;86:1276-80.
5. Cook-Mozaffari P, Newton R, Beral V, et al. The geographical distribution of Kaposi's sarcoma and of lymphomas in Africa before the AIDS epidemic. Br J Cancer 1998;78:1521-8.
6. Blauvelt A, Sei S, Cook PM, et al. Human herpesvirus 8 infection occurs following adolescence in the United States. J Infect Dis 1997;176:771-4.
7. Dedicoat M, Newton R. Review of the distribution of Kaposi's sarcoma-associated herpesvirus (KSHV) in Africa in relation to the incidence of Kaposi's sarcoma. Br J Cancer 2003;88:1-3.
8. Gao SJ, Kingsley L, Li M, et al. KSHV antibodies among Americans, Italians and Ugandans with and without Kaposi's sarcoma. Nat Med 1996;2:925-8.
9. Martro E, Bulterys M, Stewart JA, et al. Comparison of human herpesvirus 8 and Epstein-Barr virus seropositivity among children in areas endemic and non-endemic for Kaposi's sarcoma. J Med Virol 2004;72:126-31.
10. Pellett PE, Wright DJ, Engels EA, et al. Multicenter comparison of serologic assays and estimation of human herpesvirus 8 seroprevalence among US blood donors. Transfusion 2003;43:1260-8.
11. Weiss RA, Whitby D, Talbot S, et al. Human herpesvirus type 8 and Kaposi's sarcoma. J Natl Cancer Inst Monogr 1998;(23):51-4.
12. He J, Bhat G, Kankasa C, et al. Seroprevalence of human herpesvirus 8 among Zambian women of childbearing age without Kaposi's sarcoma (KS) and mother-child pairs with KS. J Infect Dis 1998;178:1787-90.
13. Cannon MJ, Dollard SC, Smith DK, et al. Blood-borne and sexual transmission of human herpesvirus 8 in women with or at risk for human immunodeficiency virus infection. N Engl J Med 2001;344:637-43.
14. Martin JN, Ganem DE, Osmond DH, et al. Sexual transmission and the natural history of human herpesvirus 8 infection. N Engl J Med 1998;338:948-54.
15. Melbye M, Cook PM, Hjalgrim H, et al. Risk factors for Kaposi's-sarcoma-associated herpesvirus (KSHV/HHV-8) seropositivity in a cohort of homosexual men, 1981-1996. Int J Cancer 1998;77:543-8.
16. Brayfield BP, Kankasa C,West JT, et al. Distribution of Kaposi sarcoma-associated herpesvirus/human herpesvirus 8 in maternal saliva and breast milk in Zambia: implications for transmission. J Infect Dis 2004;189:2260-70.
17. Dedicoat M, Newton R, Alkharsah KR, et al. Mother-to-child transmission of human herpesvirus 8 in South Africa. J Infect Dis 2004;190:1068-75.
18. Mantina H, Kankasa C, Klaskala W, et al. Vertical transmission of Kaposi's sarcoma-associated herpesvirus. Int J Cancer 2001;94:749-52.
19. HladikW, Dollard SC, Mermin J, et al. Transmission of human herpesvirus 8 by blood transfusion. N Engl J Med 2006;355:1331-8.
20. Plancoulaine S, Abel L, van Beveren M, et al. Human herpesvirus 8 transmission from mother to child and between siblings in an endemic population. Lancet 2000;356:1062-5.
21. Whitby D, Luppi M, Sabin C, et al. Detection of antibodies to human herpesvirus 8 in Italian children: evidence for horizontal transmission. Br J Cancer 2000;82:702-4.
22. Mayama S, Cuevas LE, Sheldon J, et al. Prevalence and transmission of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in Ugandan children and adolescents. Int J Cancer 1998;77:817-20.
23. Gessain A, Mauclere P, van Beveren M, et al. Human herpesvirus 8 primary infection occurs during childhood in Cameroon, Central Africa. Int J Cancer 1999;81:189-92.
24. Mbulaiteye SM, Pfeiffer RM, Whitby D, et al. Human herpesvirus 8 infection within families in rural Tanzania. J Infect Dis 2003;187:1780-5.
25. Mbulaiteye SM, Biggar RJ, Pfeiffer RM, et al. Water, socioeconomic factors, and human herpesvirus 8 infection in Ugandan children and their mothers. J Acquir Immune Defic Syndr 2005;38:474-9.
26. Plancoulaine S, Abel L, Trégouët D, et al. Respective roles of serological status and blood specific antihuman herpesvirus 8 antibody levels in human herpesvirus 8 intrafamilial transmission in a highly endemic area. Cancer Res 2004;64:8782-7.
27. Ziegler JL, Katongole-Mbidde E. Kaposi's sarcoma in childhood: an analysis of 100 cases from Uganda and relationship to HIV infection. Int J Cancer 1996;65:200-3.
28. Bayley AC. Occurrence, clinical behaviour and management of Kaposi's sarcoma in Zambia. Cancer Surv 1991;10:53-71.
29. Patil P, Elem B, Zumla A. Pattern of adult malignancies in Zambia (1980-1989) in light of the human immunodeficiency virus type 1 epidemic. J Trop Med Hyg 1995;98:281-4.
30. Patil PS, Elem B, Gwavava NJ, et al. The pattern of paediatric malignancy in Zambia (1980-1989): a hospital-based histopathological study. J Trop Med Hyg 1992;95:124-7.
31. Chintu C, Athale UH, Patil PS. Childhood cancers in Zambia before and after the HIV epidemic. Arch Dis Child 1995;73:100-4.
32. Brayfield BP, Phiri S, Kankasa C, et al. Postnatal human herpesvirus 8 and human immunodeficiency virus type 1 infection in mothers and infants from Zambia. J Infect Dis 2003;187:559-68.
33. Lennette ET, Blackbourn DJ, Levy JA. Antibodies to human herpesvirus type 8 in the general population and in Kaposi's sarcoma patients. Lancet 1996;348:858-61.
34. Kanki PJ, Allan J, Barin F, et al. Absence of antibodies to HIV-2/HTLV-4 in six central African nations. AIDS Res Hum Retroviruses 1987;3:317-22.
35. National AIDS Council. Zambia counseling and testing guidelines. Lusaka, Zambia: National AIDS Council, 2006.
36. Allison PD. Logistic regression using the SAS system: theory and application. Cary, NC: SAS Publishing, 1999.
37. Marcelin AG, Gorin I, Morand P, et al. Quantification of Kaposi's sarcoma-associated herpesvirus in blood, oral mucosa, and saliva in patients with Kaposi's sarcoma. AIDS Res Hum Retroviruses 2004;20:704-8.
38. Mbulaiteye SM, Pfeiffer RM, Engels EA, et al. Detection of Kaposi sarcoma-associated herpesvirus DNA in saliva and buffy-coat samples from children with sickle cell disease in Uganda. J Infect Dis 2004;190:1382-6.
39. Taylor MM, Chohan B, Lavreys L, et al. Shedding of human herpesvirus 8 in oral and genital secretions from HIV-1-seropositive and -seronegative Kenyan women. J Infect Dis 2004;190:484-8.
40. Serraino D, Locatelli M, Songini M, et al. Human herpes virus 8 infection among pregnant women and their children: results from the Sardinia-IDDM Study 2. Int J Cancer 2001;91:740-1.
41. Malope BI, Pfeiffer RM, Mbisa G, et al. Transmission of Kaposi sarcoma-associated herpesvirus between mothers and children in a South African population. J Acquir Immune Defic Syndr 2007;44:351-5.
42. Mbulaiteye S, Marshall V, Bagni RK, et al. Molecular evidence for mother-to-child transmission of Kaposi sarcoma-associated herpesvirus in Uganda and K1 gene evolution within the host. J Infect Dis 2006;193:1250-7.
43. Gaur A, Dominguez K, Kalish M, et al. Practice of offering a child pre-masticated food: an unrecognized possible risk factor for HIV transmission. (Abstract). Presented at the 15th Conference on Retroviruses and Opportunistic Infections, Boston, Massachusetts, February 3-6, 2008. (http://www. retroconference.org/2008/).
44. Zhu L, Wang R, Sweat A, et al. Comparison of human sera reactivities in immunoblots with recombinant human herpesvirus (HHV)-8 proteins associated with the latent (ORF73) and lytic (ORFs 65, K8.1A, and K8.1B) replicative cycles and in immunofluorescence assays with HHV-8-infected BCBL-1 cells. Virology 1999;256:381-92.
45. Biggar RJ, Engels EA, Whitby D, et al. Antibody reactivity to latent and lytic antigens to human herpesvirus 8 in longitudinally followed homosexual men. J Infect Dis 2003;187:12-18.
46. Cherpes TL, Ashley RL, Meyn LA, et al. Longitudinal reliability of focus glycoprotein G-based type-specific enzyme immunoassays for detection of herpes simplex virus types 1 and 2 in women. J Clin Microbiol 2003;41:671-4.
47. Quinlivan EB,Wang RX, Stewart PW, et al. Longitudinal seroreactivity to human herpesvirus 8 (KSHV) in the Swiss HIV Cohort 4.7 years before KS. J Med Virol 2001;64:157-66.
48. Rerksuppaphol S, Hardikar W, Dore GJ. Long-term outcome of vertically acquired and post-transfusion hepatitis C infection in children. J Gastroenterol Hepatol 2004;19:1357-62.
49. Zavitsanou A, Sypsa V, Petrodaskalaki M, et al. Human herpesvirus 8 infection in hemodialysis patients. Am J Kidney Dis 2006;47:167-70.
50. Beyari MM, Hodgson TA, Cook RD, et al. Multiple human herpesvirus 8 infection. J Infect Dis 2003;188:678-89.
51. Albrecht D, Meyer T, Lorenzen T, et al. Epidemiology of HHV-8 infection in HIV-positive patients with and without Kaposi sarcoma: diagnostic relevance of serology and PCR. J Clin Virol 2004;30:145-9.
52. Ashley RL. Sorting out the new HSV type specific antibody tests. Sex Transm Infect 2001;77:232-7.
53. De Baets AJ, Bulterys M, Abrams EJ, et al. Care and treatment of HIV-infected children in Africa: issues and challenges at the district hospital level. Pediatr Infect Dis J 2007;26:163-73.
54. Bolton-Moore C, Mubiana-Mbewe M, Cantrell RA, et al. Clinical outcomes and CD4 cell response in children receiving antiretroviral therapy at primary health care facilities in Zambia. JAMA 2007;298:1888-99.