Transanal delivery of angiotensin converting enzyme inhibitor prevents colonic fibrosis in a mouse colitis model: development of a unique mode of treatment

Surgery

Volumn 144, Issue 2, 2008, Pages 259-268

  Koga, Hiroyuki ^a   Yang, Hua ^a   Adler, Jeremy ^a   Zimmermann, Ellen M ^a   Teitelbaum, Daniel H ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEXTRAN; ENALAPRILAT; MACROGOL; SMAD PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; SODIUM SULFATE; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLITIS; COLON DISEASE; COLON FIBROSIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; HISTOPATHOLOGY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ADMINISTRATION, RECTAL; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; COLITIS; COLLAGEN; COLON; DEXTRAN SULFATE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENALAPRILAT; FIBROSIS; INTERLEUKIN-1BETA; INTESTINAL MUCOSA; MALE; MICE; MICE, INBRED C57BL; SMAD PROTEINS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 47549100828     PISSN: 00396060     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.surg.2008.03.043     Document Type: Article

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