Surface morphology of spray-dried nanoparticle-coated microparticles designed as an oral drug delivery system

Brazilian Journal of Chemical Engineering

Volumn 25, Issue 2, 2008, Pages 389-398

  Beck, R C R ^a   Lionzo, M I Z ^a   Costa, T M H ^a   Benvenutti, E V ^a   Re M I ^b   Gallas, M R ^a   Pohlmann, A R ^a   Guterres, S S ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b Instituto de Pesquisas Tecnologicas   (Brazil)

Author keywords

Coated microparticles; Nanocapsules; Nanoparticles; SEM; Spray drying; X ray diffraction

Indexed keywords

COATINGS; DRYING; NANOCAPSULES; NANOPARTICLES; NANOSPHERES; SCANNING ELECTRON MICROSCOPY; SPRAY DRYING; X RAY ANALYSIS; X RAY DIFFRACTION;

COATING MATERIAL; DRUG MODEL; MICRO-PARTICLES; MORPHOLOGICAL CHARACTERISTIC; ORAL DRUG DELIVERY SYSTEM; SEM ANALYSIS; SPRAY DRIED; SURFACE AREA;

NANOSTRUCTURES;

EID: 47549095669     PISSN: 01046632     EISSN: None     Source Type: Journal    
DOI: 10.1590/S0104-66322008000200016     Document Type: Article

References (36)

1. Barratt, G. M., Therapeutic applications of colloidal drug carriers. Pharmaceutical Science & Technology Today, 3, 163-171 (2000).
2. Barret, E. P., Joyner, L. G. and Halenda, P. P., The determination of pore volume and area distributions in porous substances. I. Computations from nitrogen isotherms. Journal of the American Chemical Society, 73, 373-380 (1951).
3. Beck, R. C. R. B., Haas, S. E., Guterres, S. S., Re, M. I., Benvenutti, E. V. and Pohlmann, A. R., Nanoparticle-coated organic-inorganic microparticles: Experimental design and gastrointestinal tolerance evaluation, Quimica Nova, 29, 990-996 (2006).
4. Beck, R. C. R., Pohlmann, A. R. and Guterres, S. S., Nanoparticle coated microparticles: Preparation and characterization, Journal of Microencapsulation, 21, 499-512 (2004).
5. Benita, S., Microencapsulation: Methods and Industrial Applications, Marcel Dekker, New York, USA (1996).
6. Blanco, M. D., Bernardo, M. V., Sastre, R. L., Olmo, R., Muñiz, E. and Teijón, J. M., Preparation of bupivacaine-loaded poly(e-caprolactone) microspheres by spray-drying: Drug release studies and biocompatibility, European Journal of Pharmaceutics and Biopharmaceutics, 55, 229-236 (2003).
7. Brunauer, S., Emmet, P. H. and Teller, E., Adsorption of gases in multimolecular layers, Journal of the Chemical Society, 60, 309-319 (1938).
8. Chen, J.-G., Ding, H.-M., Wang, J. X. and Shao, L., Preparation and characterization of porous hollow silica nanoparticles for drug delivery application, Biomaterials, 25, 723-727 (2004).
9. Cherkaoui, I., Monticone, V., Vaution, C. and Treiner, C., Coadsorption of the sodium salts of two steroid molecules at a silica/interface as induced by the adsorption of a cationic surfactant, International Journal of Pharmaceutics, 201, 71-77 (2000).
10. Cherkaoui, I., Monticone, V., Vaution, C. and Treiner, C., Surface modification of silica particles by a cationic surfactant: Adsolubilization of steroids from aqueous solutions, International Journal of Pharmaceutics, 176, 111-120 (1998).
11. Chiarini, A., Tartarini, A. and Fini, A., pH-solubility relationship and partition coefficients for some anti-inflammatory arylaliphatic acids, Archiv der Pharmazie, 317, 268-273 (1984).
12. Conte, U., Conti, B., Giunchedi, P. and Maggi, L., Spray dried polylactide microsphere preparation: Influence of the technological parameters, Drug Development and Industrial Pharmacy, 20, 235-258 (1994).
13. Couvreur, P., Dubernet, C. and Puisieux, F., Controlled drug delivery with nanoparticles: Current possibilities and future trends, European Journal of Pharmaceutics and Biopharmaceutics, 41, 2-13 (1995).
14. Cypes, S. H., Saltzman, W. M. and Giannelis, E. P., Organosilicate- polymer drug delivery systems: Controlled release and enhanced mechanical properties, Journal of Controlled Release, 90, 163-169 (2003).
15. Fessi, H., Puisieux, F. and Devissaguet, J.-Ph., European Patent 0274961, A1 (1988).
16. Guterres, S. S., Müller, C. R., Pohlmann, A. R. and Dalla-Costa, T., Gastro-intestinal tolerance following oral administration of spray-dried diclofenac-loaded nanocapsules and nanospheres. STP Pharma Sciences, 11, 229-233 (2001).
17. Guterres, S. S., Pohlmann, A. R., Dalla-Costa, T., Bassani, V. L. and Muller, C. R., Procédé de séchage de suspensions colloïdales de nanocapsules et de nanospheres polymères par aspersion, French Patent 2,801,227 (2000).
18. Huang, Y. C., Chiang, C. H. and Yeh, M. K., Optimizing formulation factors in preparing chitosan microparticles by spray-drying methods, Journal of Microencapsulation, 20, 247-260 (2003).
19. Kawashima, Y., Iwamoto, T., Niwa, T., Takeuchi, H. and Hino, T., Uniform and improved bioavailability of newly developed rapid and sustained release suspensions of ibuprofen microspheres, International Journal of Pharmaceutics, 89, 9-17 (1993).
20. Kawashima, Y., Serigano, T., Hino, T., Yamamoto, H. and Takeuchi, H., Design of inhalation dry powder of pranlukast hydrate to improve dispersibility by the surface modification with light anhydrous silicic acid (Aerosil 200), International Journal of Pharmaceutics, 173, 243-251 (1998).
21. Kneuer, C., Sameti, M., Bakowsky, U., Schiestel, T., Schirra, H., Schmidt, H. and Lehr, C.-M., A nonviral DNA delivery system based on the surface modified silica-nanoparticles can efficiently transfect cells in vitro, Bioconjugate Chemistry, 11, 926-932 (2000).
22. Kortesuo, P., Ahola, M., Kangas, M., Jokinen, M., Leino, T., Vuorilehto, L., Laakso, S., Kiesvaara, J., Yli-Urpo, A. and Marvola, M., Effect of synthesis parameteres of the sol-gel-processed spray-dried silica gel microparticles on the release rate of dexmedetomidine, Biomaterials, 23, 2795-2801 (2002).
23. Lin, S. and Kao, Y., Tablet formulation study of spray-dried sodium diclofenac enteric-coated microcapsules, Pharmaceutical Research, 8, 919-924 (1991).
24. Maia, J. L., Santana, M. H. A. and Ré, M. I., The effect of some processing conditions on the characteristics of biodegradable microspheres obtained by an emulsion solvent evaporation process, Brazilian Journal of Chemical Enginnering, 21, 1-12 (2004).
25. Müller, C. R., Bassani, V. L., Pohlmann, A. R., Michalowski, C. B., Petrovick, P. R. and Guterres S. S., Preparation and characterization of spraydried polymeric nanocapsules, Drug Development and Industrial Pharmacy, 26, 343-347 (2000).
26. Müller, C. R., Schaffazick, S. R., Pohlmann, A. R., Freitas, L. L., da Silveira, N. P., Dalla-Costa, T. and Guterres, S. S., Spray-dried diclofenacloaded poly(ε-caprolactone) nanocapsules and nanospheres: Preparation and physicochemical characterization, Pharmazie, 56, 864-867 (2001).
27. Murillo, M., Gamazo, C., Goñi, M. M., Irache, J. M. and Blanco-Prieto, M. J., Development of microparticles prepared by spray-drying as a vaccine delivery system against brucellosis, International Journal of Pharmaceutics, 242, 341-344 (2002).
28. Oliveira, B. F., Santana M. H. A. and Ré, M. I., Spray-dried chitosan microspheres cross-linked with d, 1-glyceraldehyde as a potential drug delivery system: Preparation and characterization, Brazilian Journal of Chemical Engineering, 22, 353-360 (2005).
29. Oneda, F. and Re, M. I., The effect of formulation variables on the dissolution and physical properties of spray-dried microspheres containing organic salts, Powder Technology, 130, 377-384 (2003).
30. Pohlmann, A. R., Soares, L. U., Cruz, L., da Silveira, N. P. and Guterres, S. S., Alkaline hydrolysis as a tool to determine the association form of indomethacin in nanocapsules prepared with poly(ε-caprolactone), Current Drug Delivery, 1, 103-110 (2004).
31. Pohlmann, A. R., Weiss, V., Mertins, O., da Silveira, N. P. and Guterres, S. S., Spray-dried indomethacin-loaded polyester nanocapsules and nanospheres: Development, stability evaluation and nanostructure models, European Journal of Pharmaceutical Sciences, 16, 305-312 (2002).
32. Raffin, R. P., Obach, E. S., Mezzalira, G., Pohlmann, A. R. and Guterres, S. S., Nanocápsulas poliméricas secas contendo indometacina: estudo de formulação e de tolerância gastrintestinal em ratos, Acta Farm Bonaerense, 22, 163-172 (2003).
33. Sameti, M., Bohr, G., Ravi Kumar, M. N. V., Kneuer, C., Bakowsky, U., Nacken, M., Schmidt, H. and Lehr, C-M., Stabilisation by freeze-drying of cationially modified silica nanoparticles for gene delivery, International Journal of Pharmaceutics, 266, 51-60 (2003).
34. Schaffazick, S. R., Guterres, S. S., Freitas, L. L. and Pohlmann, A. R., Caracterização e estabilidade físico-química de sistemas poliméricos nanoparticulados para administração de fármacos, Quimica Nova, 26, 726-737 (2003).
35. Smirnova, I., Mamic, J. and Arlt, W., Adsorption of drugs on silica aerogels, Langmuir, 19, 8521-8525 (2003).
36. Wan, L. S. C., Heng, W. S. C. and Chia, G. H., Spray drying as a process for microencapsulation and the effect of different coating polymers, Drug Development and Industrial Pharmacy, 18, 997-1011 (1992).