cGMP activates a pH-sensitive leak K+ current in the presumed cholinergic neuron of basal forebrain

Journal of Neurophysiology

Volumn 99, Issue 5, 2008, Pages 2126-2133

  Toyoda, Hiroki ^a   Saito, Mitsuru ^a   Sato, Hajime ^a   Dempo, Yoshie ^c   Ohashi, Atsuko ^c   Hirai, Toshihiro ^c   Maeda, Yoshinobu ^b   Kaneko, Takeshi ^d   Kang, Youngnam ^a,c  

^a OSAKA UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY DENTAL HOSPITAL   (Japan)

^c HEALTH SCIENCES UNIVERSITY OF HOKKAIDO   (Japan)

^d KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

8 BROMO CYCLIC GMP; BARIUM; 8-BROMOCYCLIC GMP; CYCLIC GMP; DRUG DERIVATIVE; TANDEM PORE DOMAIN POTASSIUM CHANNEL; TASK PROTEIN, RAT;

ARTICLE; CHOLINERGIC ACTIVITY; DEPOLARIZATION; FOREBRAIN; HYPERPOLARIZATION; NERVE CELL; PH MEASUREMENT; POTASSIUM CURRENT; PRIORITY JOURNAL; ANIMAL; CELL MEMBRANE POTENTIAL; CHOLINERGIC SYSTEM; CYTOLOGY; DRUG EFFECT; ELECTROPHYSIOLOGY; IN VITRO STUDY; PATCH CLAMP; PH; PHYSIOLOGY; RAT;

ANIMALS; BARIUM; CYCLIC GMP; ELECTROPHYSIOLOGY; HYDROGEN-ION CONCENTRATION; MEMBRANE POTENTIALS; NEURONS; PARASYMPATHETIC NERVOUS SYSTEM; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS, TANDEM PORE DOMAIN; PROSENCEPHALON; RATS;

EID: 47549094871     PISSN: 00223077     EISSN: 15221598     Source Type: Journal    
DOI: 10.1152/jn.01051.2007     Document Type: Article

References (26)

1. Abudara V, Alvarez AF, Chase MH, Morales FR. Nitric oxide as an anterograde neurotransmitter in the trigeminal motor pool. J Neurophysiol 88: 497-506, 2002.
2. + (TASK) channels containing TASK-1 (KCNK3) and TASK-3 (KCNK9) subunits. J Neurosci 24: 6693-6702, 2004.
3. + channels TALK-1 and TALK-2 are activated by nitric oxide and reactive oxygen species. J Physiol 562: 235-244, 2005.
4. + channel to sense external pH variations near physiological pH. EMBO J 16: 5464-5471, 1997.
5. Farkas RH, Nakajima S, Nakajima Y. Neurotensin excites basal forebrain cholinergic neurons: ionic and signal-transduction mechanisms. Proc Natl Acad Sci USA 91: 2853-2857, 1994.
6. + channels. Science 266: 1068-1072, 1994.
7. Gonzalez-Forero D, Portillo F, Gomez L, Montero F, Kasparov S, Moreno-Lopez B. Inhibition of resting potassium conductances by long-term activation of the NO/cGMP/protein kinase G pathway: a new mechanism regulating neuronal excitability. J Neurosci 27: 6302-6312, 2007.
8. Hille B. Ion Channels of Excitable Membranes (3rd ed.). Sunderland, MA: Sinauer, 2001, p. 814.
9. Kang D, Han J, Talley EM, Bayliss DA, Kim D. Functional expression of TASK-1/TASK-3 heteromers in cerebellar granule cells. J Physiol 554: 64-77, 2004.
10. + currents in the presumed cholinergic neuron of basal forebrain. J Neurophysiol 98: 3397-3410, 2007.
11. + channel subunit, TASK-5, associated with the central auditory nervous system. Mol Cell Neurosci 18: 632-648, 2001.
12. + channel (cTBAK-1). Circ Res 82: 513-518, 1998.
13. Leonoudakis D, Gray AT, Winegar BD, Kindler CH, Harada M, Taylor DM, Chavez RA, Forsayeth JR, Yost CS. An open rectifier potassium channel with two pore domains in tandem cloned from rat cerebellum. J Neurosci 18: 868-877, 1998.
14. Lopatin AN, Makhina EN, Nichols CG. Potassium channel block by cytoplasmic polyamines as the mechanism of intrinsic rectification. Nature 372: 366-369, 1994.
15. Markram H, Segal M. Electrophysiological characteristics of cholinergic and non-cholinergic neurons in the rat medial septum-diagonal band complex. Brain Res 513: 171-174, 1990.
16. 2+. Nature 325: 156-159, 1987.
17. McCormick DA. Neurotransmitter actions in the thalamus and cerebral cortex and their role in neuromodulation of thalamocortical activity. Prog Neurobiol 39: 337-388, 1992.
18. + channel 1 (TASK1) and TASK3 channels to the control of activity modes in thalamocortical neurons. J Neurosci 23: 6460-6469, 2003.
19. Millar JA, Barratt L, Southan AP, Page KM, Fyffe RE, Robertson B, Mathie A. A functional role for the two-pore domain potassium channel TASK-1 in cerebellar granule neurons. Proc Natl Acad Sci USA 97: 3614-3618, 2000.
20. + channels expressed in Xenopus oocytes. J Physiol 562: 687-696, 2005.
21. + channels. Trends Neurosci 24: 339-346, 2001.
22. + channel is a molecular substrate for neuronal effects of inhalation anesthetics. J Neurosci 20: 6347-6354, 2000.
23. + channel, is modulated by multiple neurotransmitters in motoneurons. Neuron 25: 399-410, 2000.
24. Talley EM, Solorzano G, Lei Q, Kim D, Bayliss DA. CNS distribution of members of the two-pore-domain (KCNK) potassium channel family. J Neurosci 21: 7491-7505, 2001.
25. + conductance. J Neurosci 22: 1256-1265, 2002.
26. West AR, Grace AA. The nitric oxide-guanylyl cyclase signaling pathway modulates membrane activity states and electrophysiological properties of striatal medium spiny neurons recorded in vivo. J Neurosci 24: 1924-1935, 2004.