Antisecretory factor expression is regulated by inflammatory mediators and influences the severity of experimental autoimmune encephalomyelitis

Journal of Leukocyte Biology

Volumn 76, Issue 4, 2004, Pages 835-844

  Davidson, Todd S ^a   Hickey, William F ^a,b  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b DARTMOUTH HITCHCOCK MEDICAL CENTER   (United States)

Author keywords

Cytokine; Immunosuppression; Macrophage; T lymphocyte

Indexed keywords

ANTIBODY; ANTISECRETORY FACTOR ANTIBODY TLD 1A8A; CYTOKINE; INTERLEUKIN 10; INTERLEUKIN 6; INTERLEUKIN 8; MESSENGER RNA; STOMACH SECRETION INHIBITOR; UNCLASSIFIED DRUG;

ADOPTIVE TRANSFER; ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE DURATION; DISEASE MODEL; DISEASE SEVERITY; DOWN REGULATION; EFFECTOR CELL; IMMUNOMODULATION; INFLAMMATION; LYMPHOCYTE PROLIFERATION; MACROPHAGE; MEMORY CELL; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; UPREGULATION;

ADOPTIVE TRANSFER; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIDIARRHEALS; CELL DIVISION; CENTRAL NERVOUS SYSTEM; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; GENE EXPRESSION REGULATION; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-18; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; NEUROPEPTIDES; RATS; RATS, INBRED LEW; T-LYMPHOCYTES; TISSUE DISTRIBUTION;

ANIMALIA;

EID: 4744375507     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0204085     Document Type: Article

References (13)

1. Hickey, W. K., Kimura, H. (1988) Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo. Science 239, 290-292.
2. Aloisi, F. (2001) Immune function of microglia. Glia 36, 165-179.
3. Williams, K. C., Zhao, W., Politopoulou, G., Male, D., Hickey, W. F. (2000) Inhibition of experimental allergic encephalomyelitis with an antibody that recognizes a novel antigen expressed on lymphocytes, endothelial cells, and microglia. Lab. Invest. 80, 313-326.
4. Male, D., Rahman, J., Liuke, A., Zhao, W., Hickey, W. (1995) An interferon-inducible molecule on brain endothelium which controls lymphocyte adhesion mediated by integrins. Immunology 84, 453-460.
5. Flaris, N. A., Densmore, T. L., Molleston, M. C., Hickey, W. F. (1993) Characterization of microglia and macrophages in the central nervous system of rats: definition of the differential expression of molecules using standard and novel monoclonal antibodies in normal CNS and in four models of parenchymal reaction. Glia 7, 34-40.
6. Davidson, T. S., Hickey, W. F. (2004) Distribution and immunoregulatory properties of antisecretory factor. Lab. Invest. 84, 307-319.
7. Lonnroth, L., Lange, S. (1986) Purification and characterization of the antisecretory factor: a protein in the central nervous system and in the gut which inhibits intestinal hypersecretion induced by cholera toxin. Biochim. Biophys. Acta 883, 138-144.
8. Hickey, W. F. (1999) Leukocyte traffic in the central nervous system: the participants and their roles. Semin. Immunol. 11, 125-137.
9. Mannie, M. D., Paterson, P. Y., Prichard, D.C., Flouret, O. (1985) Induction of experimental allergic encephalomyelitis in Lewis rats with purified synthetic peptides: delineation of antigenic determinants for encephalitogenicity, in vitro activation of cellular transfer, and proliferation of lymphocytes. Proc. Natl. Acad. Sci. USA 82, 5515-5519.
10. Hickey, W. F., Cohen, J. A., Burns, J. B. (1987) A quantitative immunohistochemical comparison of actively versus adoptively induced experimental allergic encephalomyelitis in the Lewis rat. Cell. Immunol. 109, 272-281.
11. Lange, S., Jennische, E., Johansson, E., Lonnroth, I. (1999) The antisecretory factor: synthesis and intracellular localisation in porcine tissues. Cell Tissue Res. 296, 607-617.
12. Lange, S., Lonnroth, I. (2001) The antisecretory factor: synthesis, anatomical and cellular distribution, and biological action in experimental and clinical studies. Int. Rev. Cytol. 210, 39-75.
13. Gasser, D. L., Goldner-Sauve, A., Hickey, W. F. (1990) Genetic control of resistance to clinical EAE accompanied by histological symptoms. Immunogenetics 31, 377-382.