Targeting HIF-α: When a magic arrow hits the bull's eye

Drug Discovery Today

Volumn 9, Issue 20, 2004, Pages 869-

  Huang, L Eric ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Drug Discovery

Indexed keywords

2 OXOGLUTARIC ACID; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; IMATINIB;

ANGIOGENESIS; DRUG TARGETING; GLYCOLYSIS; HUMAN; NOTE;

ANOXIA; DOWN-REGULATION; ENZYME INHIBITORS; HUMANS; HYDROXYLATION; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; PIPERAZINES; PROTEIN-TYROSINE KINASES; PYRIMIDINES; TRANSCRIPTION FACTORS; UP-REGULATION;

EID: 4744370953     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(04)03227-1     Document Type: Note

References (5)

1. Hewitson K.S., Schofield C.J. The HIF pathway as a therapeutic target. Drug Discov. Today. 9:2004;704-711
2. Semenza G.L. Targeting HIF-1 for cancer therapy. Nat. Rev. Cancer. 3:2003;721-732
3. Giaccia A., et al. HIF-1 as a target for drug development. Nat. Rev. Drug Discov. 2:2003;803-811
4. Huang L.E., Bunn H.F. Hypoxia-inducible factor and its biomedical relevance. J. Biol. Chem. 278:2003;19575-19578
5. Koshiji M., et al. HIF-1alpha induces cell cycle arrest by functionally counteracting Myc. EMBO J. 12:2001;1949-1956