Analysis of reciprocal congenic lines reveals the C3H/HeJ genome to be highly resistant to Apc Min intestinal tumorigenesis

Genomics

Volumn 84, Issue 5, 2004, Pages 844-852

  Koratkar, Revati ^a   Silverman, Karen A ^a   Pequignot, Ed ^b   Hauck, Walter W ^b   Buchberg, Arthur M ^a   Siracusa, Linda D ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Apc; C3H HeJ; C57BL 6J; Colon cancer; Congenic; intestine; Min; Modifier genes; Mouse; Polyp

Indexed keywords

ALLELE; ARTICLE; CARCINOGENESIS; COLON POLYP; CONGENIC STRAIN; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE LOCUS; GENOME ANALYSIS; INTESTINE POLYP; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROGENY;

ADENOMATOUS POLYPOSIS COLI; ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; CHROMOSOMES, MAMMALIAN; DISEASE MODELS, ANIMAL; FEMALE; GENES, APC; GENOME; INTESTINAL POLYPS; MALE; MICE; MICE, CONGENIC; MICE, INBRED C3H; PHENOTYPE; PHOSPHOLIPASES A;

EID: 4744368614     PISSN: 08887543     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ygeno.2004.07.010     Document Type: Article

References (46)

1. N.S. Fearnhead, M.P. Britton, and W.F. Bodmer The ABC of APC Hum. Mol. Genet. 10 2001 721 733
2. G. Lal, and S. Gallinger Familial adenomatous polyposis Semin. Surg. Oncol. 18 2000 314 323
3. J. Groden Identification and characterization of the familial adenomatous polyposis coli gene Cell 66 1991 589 600
4. K.W. Kinzler Identification of FAP locus genes from chromosome 5q21 Science 253 1991 661 665
5. I. Nishisho Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients Science 253 1991 665 669
6. S.M. Powell APC mutations occur early during colorectal tumorigenesis Nature 359 1992 235 237
7. P. Paul Identical APC exon 15 mutations result in a variable phenotype in familial adenomatous polyposis Hum. Mol. Genet. 2 1993 925 931
8. F.M. Giardiello Phenotypic variability of familial adenomatous polyposis in 11 unrelated families with identical APC gene mutation Gastroenterology 106 1994 1542 1547
9. R. Fodde, and P.M. Khan Genotype-phenotype correlations at the adenomatous polyposis coli (APC) gene Crit. Rev. Oncog. 6 1995 291 303
10. G. Griffioen Extracolonic manifestations of familial adenomatous polyposis: desmoid tumours, and upper gastrointestinal adenomas and carcinomas Scand. J. Gastroenterol. Suppl. 225 1998 85 91
11. H. Nagase Correlation between the location of germ-line mutations in the APC gene and the number of colorectal polyps in familial adenomatous polyposis patients Cancer Res. 52 1992 4055 4057
12. L. Spirio Alleles of the APC gene: an attenuated form of familial polyposis Cell 75 1993 951 1657
13. Z. Dobbie Mutational analysis of the first 14 exons of the adenomatous polyposis coli (APC) gene Eur. J. Cancer. 11 1994 1709 1713
14. S.A. Gayther Regionally clustered APC mutations are associated with a severe phenotype and occur at a high frequency in new mutation cases of adenomatous polyposis coli Hum. Mol. Genet. 3 1994 53 56
15. K.P. Nugent Phenotypic expression in familial adenomatous polyposis: partial prediction by mutation analysis Gut 35 1994 1622 1623
16. I.P. Tomlinson A modifying locus for familial adenomatous polyposis may be present on chromosome 1p35-p36 J. Med. Genet. 33 1996 268 273
17. Z. Dobbie Identification of a modifier gene locus on chromosome 1p35-36 in familial adenomatous polyposis Hum. Genet. 99 1997 653 657
18. M.D. Crabtree Explaining variation in familial adenomatous polyposis: relationship between genotype and phenotype and evidence for modifier genes Gut 51 2002 420 423
19. R. Fodde A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors Proc. Natl. Acad. Sci. USA 91 1994 8969 8973
20. M. Oshima Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene Proc. Natl. Acad. Sci. USA 92 1995 4482 4486
21. H. Shibata Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene Science 278 1997 120 123
22. C.F. Quesada Piroxicam and acarbose as chemopreventive agents for spontaneous intestinal adenomas in APC gene 1309 knockout mice Jpn. J. Cancer Res. 89 1998 392 396
23. R. Smits Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development Genes Dev. 13 1999 1309 1321
24. H. Sasai, M. Masaki, and K. Wakitani Suppression of polypogenesis in a new mouse strain with a truncated Apc(Delta474) by a novel COX-2 inhibitor, JTE-522 Carcinogenesis 21 2000 953 958
25. A.R. Moser, H.C. Pitot, and W.F. Dove A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse Science 247 1990 322 324
26. A.R. Moser Homozygosity for the Min allele of Apc results in disruption of mouse development prior to gastrulation Dev. Dyn. 203 1995 422 433
27. L.K. Su Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene [published erratum appears in Science 1992 May 22;256(5060):1114] Science 256 1992 668 670
28. Y. Miyoshi Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients Proc. Natl. Acad. Sci. USA 89 1992 4452 4456
29. M. Miyaki Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumors Cancer Res. 54 1994 3011 3020
30. A.R. Moser The Min (multiple intestinal neoplasia) mutation: its effect on gut epithelial cell differentiation and interaction with a modifier system J. Cell Biol. 116 1992 1517 1526
31. W.F. Dietrich Genetic identification of Mom-1, a major modifier locus affecting Min- induced intestinal neoplasia in the mouse Cell 75 1993 631 639
32. K.A. Gould Mom1 is a semi-dominant modifier of intestinal adenoma size and multiplicity in Min/+ mice Genetics 144 1996 1769 1776
33. M. MacPhee The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia Cell 81 1995 957 966
34. B.P. Kennedy A natural disruption of the secretory group II phospholipase A2 gene in inbred mouse strains J. Biol. Chem. 270 1995 22378 22385
35. K.A. Gould Genetic evaluation of candidate genes for the Mom1 modifier of intestinal neoplasia in mice Genetics 144 1996 1777 1785
36. R.T. Cormier Secretory phospholipase Pla2g2a confers resistance to intestinal tumorigenesis [see comments] Nature Genet. 17 1997 88 91
37. R.T. Cormier The Mom1AKR intestinal tumor resistance region consists of Pla2g2a and a locus distal to D4Mit64 Oncogene 19 2000 3182 3192
38. L.M. Silver Mouse Genetics, Concepts and Applications 1995 Oxford Univ. Press New York
39. J.C. Crabbe Identifying genes for alcohol and drug sensitivity: recent progress and future directions Trends Neurosci. 22 1999 173 179
40. R. Koratkar The CAST/Ei strain confers significant protection against Apc(Min) intestinal polyps, independent of the resistant modifier of Min 1 (Mom1) locus Cancer Res. 62 2002 5413 5417
41. A. Poltorak Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene Science 282 1998 2085 2088
42. S.T. Qureshi Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4) J. Exp. Med. 189 1999 615 625
43. K. Hoshino Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product J. Immunol. 162 1999 3749 3752
44. J.L. Imler, and J.A. Hoffmann Toll and Toll-like proteins: an ancient family of receptors signaling infection Rev. Immunogenet. 2 2000 294 304
45. K. Takeda, and S. Akira Toll receptors and pathogen resistance Cell Microbiol. 5 2003 143 153
46. K.A. Silverman Identification of the modifier of Min 2 (Mom2) locus, a new mutation that influences Apc-induced intestinal neoplasia Genome Res. 12 2002 88 97