Expression of CCR2 on monocytes and macrophages in chronically inflamed skin in atopic dermatitis and psoriasis

Acta Dermato-Venereologica

Volumn 84, Issue 5, 2004, Pages 353-358

  Vestergaard, Christian ^a,b   Just, Helle ^a   Baumgartner Nielsen, Jane ^a   Thestrup Pedersen, Kristian ^a   Deleuran, Mette ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Atopic dermatitis; CCL2; CCR2; Chemokines; Monocytes

Indexed keywords

BETA CHEMOKINE; CD163 ANTIGEN; CHEMOKINE; CHEMOKINE RECEPTOR CCR2; GAMMA INTERFERON; MONOCYTE CHEMOTACTIC PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANTIGEN EXPRESSION; ARTICLE; ATOPIC DERMATITIS; CHRONIC INFLAMMATION; CLINICAL ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; HUMAN; HUMAN CELL; HUMAN TISSUE; INFLAMMATION; KERATINOCYTE; MACROPHAGE; MONOCYTE; NEUTROPHIL CHEMOTAXIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PSORIASIS; RECEPTOR BINDING; SKIN BIOPSY; SKIN INFLAMMATION;

ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; CELL CULTURE TECHNIQUES; CHEMOKINE CCL2; CHRONIC DISEASE; DERMATITIS, ATOPIC; HUMANS; INTERFERON TYPE II; KERATINOCYTES; MACROPHAGES; MONOCYTES; PSORIASIS; RECEPTORS, CELL SURFACE; RECEPTORS, CHEMOKINE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 4744352502     PISSN: 00015555     EISSN: None     Source Type: Journal    
DOI: 10.1080/00015550410034444     Document Type: Article

References (26)

1. Leung DY, Bieber T. Atopic dermatitis. Lancet 2003; 361: 151-160.
2. Bos JD, de Rie MA. The pathogenesis of psoriasis: immunological facts and speculations. Immunol Today 1999; 20: 40-46.
3. Luster AD. Chemokines - chemotactic cytokines that mediate inflammation. N Engl J Med 1998; 338: 436-445.
4. Frade JM, Mellado M, del Real G, Gutierrez-Ramos JC, Lind P, Martinez AC. Characterization of the CCR2 chemokine receptor: functional CCR2 receptor expression in B cells. J Immunol 1997; 159: 5576-5584.
5. Vanbervliet B, Homey B, Durand I, Massacrier C, Ait-Yahia S, de Bouteiller O, et al. Sequential involvement of CCR2 and CCR6 ligands for immature dendritic cell recruitment: possible role at inflamed epithelial surfaces. Eur J Immunol 2002; 32: 231-242.
6. Tylaska LA, Boring L, Weng W, Aiello R, Charo IF, Rollins BJ, et al. Ccr2 regulates the level of MCP-1/CCL2 in vitro and at inflammatory sites and controls T cell activation in response to alloantigen. Cytokine 2002; 18: 184-190.
7. Boring L, Gosling J, Cleary M, Charo IF. Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis. Nature 1998; 394: 894-897.
8. Stein O, Dabach Y, Ben-Naim M, Halperin G, Charo IF, Stein Y. In CCR2-/- mice monocyte recruitment and egress of LDL cholesterol in vivo is impaired. Biochem Biophys Res Commun 2003; 300: 477-481.
9. Katschke KJ Jr, Rottman JB, Ruth JH, Qin S, Wu L, LaRosa G, et al. Differential expression of chemokine receptors on peripheral blood, synovial fluid, and synovial tissue monocytes/macrophages in rheumatoid arthritis. Arthritis Rheum 2001; 44: 1022-1032.
10. Giustizieri ML, Mascia F, Frezzolini A, De Pita O, Chinni LM, Giannetti A, et al. Keratinocytes from patients with atopic dermatitis and psoriasis show a distinct chemokine production profile in response to T cell-derived cytokines. J Allergy Clin Immunol 2001; 107: 871-877.
11. Deleuran M, Buhl L, Ellingsen T, Harada A, Larsen CG, Matsushima K, et al. Localization of monocyte chemotactic and activating factor (MCAF/MCP-1) in psoriasis. J Dermatol Sci 1996; 13: 228-236.
12. Gillitzer R, Wolff K, Tong D, Muller C, Yoshimura T, Hartmann AA, et al. MCP-1 mRNA expression in basal keratinocytes of psoriatic lesions. J Invest Dermatol 1993; 101: 127-131.
13. Kaburagi Y, Shimada Y, Nagaoka T, Hasegawa M, Takehara K, Sato S. Enhanced production of CC-chemokines (RANTES, MCP-1, MIP-1alpha, MIP-1beta, and eotaxin) in patients with atopic dermatitis. Arch Dermatol Res 2001; 293: 350-355.
14. Li J, Farthing PM, Thornhill MH. Oral and skin keratinocytes are stimulated to secrete monocyte chemoattractant protein-1 by tumour necrosis factor-alpha and interferon-gamma. J Oral Pathol Med 2000; 29: 438-444.
15. Kragballe K, Desjarlais L, Marcelo CL. Increased DNA synthesis of uninvolved psoriatic epidermis is maintained in vitro. Br J Dermatol 1985; 112: 263-270.
16. Barker JN, Jones ML, Swenson CL, Sarma V, Mitra RS, Ward PA, et al. Monocyte chemotaxis and activating factor production by keratinocytes in response to IFN-gamma. J Immunol 1991; 146: 1192-1197.
17. Boring L, Gosling J, Chensue SW, Kunkel SL, Farese RV Jr, Broxmeyer HE, et al. Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice. J Clin Invest 1997; 100: 2552-2561.
18. Kurihara T, Warr G, Loy J, Bravo R. Defects in macrophage recruitment and host defense in mice lacking the CCR2 chemokine receptor. J Exp Med 1997; 186: 1757-1762.
19. Maus UA, Waelsch K, Kuziel WA, Delbeck T, Mack M, Blackwell TS, et al. Monocytes are potent facilitators of alveolar neutrophil emigration during lung inflammation: role of the CCL2-CCR2 axis. J Immunol 2003; 170: 3273-3278.
20. Kuziel WA, Morgan SJ, Dawson TC, Griffin S, Smithies O, Ley K, et al. Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2. Proc Natl Acad Sci U S A 1997; 94: 12053-12058.
21. Sato N, Ahuja SK, Quinones M, Kostecki V, Reddick RL, Melby PC, et al. CC chemokine receptor (CCR)2 is required for langerhans cell migration and localization of T helper cell type 1 (Th1)-inducing dendritic cells. Absence of CCR2 shifts the Leishmania major-resistant phenotype to a susceptible state dominated by Th2 cytokines, b cell outgrowth, and sustained neutrophilic inflammation. J Exp Med 2000; 192: 205-218.
22. Penton-Rol G, Polentarutti N, Luini W, Borsatti A, Mancinelli R, Sica A, et al. Selective inhibition of expression of the chemokine receptor CCR2 in human monocytes by IFN-gamma. J Immunol 1998; 160: 3869-3873.
23. Sulahian TH, Hogger P, Wahner AE, Wardwell K, Goulding NJ, Sorg C, et al. Human monocytes express CD163, which is upregulated by IL-10 and identical to p155. Cytokine 2000; 12: 1312-1321.
24. Buechler C, Ritter M, Orso E, Langmann T, Klucken J, Schmitz G. Regulation of scavenger receptor CD163 expression in human monocytes and macrophages by pro- and antiinflammatory stimuli. J Leukoc Biol 2000; 67: 97-103.
25. Szegedi A, Aleksza M, Gonda A, Irinyi B, Sipka S, Hunyadi J, et al. Elevated rate of Thelper1 (T(H)1) lymphocytes and serum IFN-gamma levels in psoriatic patients. Immunol Lett 2003; 86: 277-280.
26. Yoshizawa Y, Nomaguchi H, Izaki S, Kitamura K. Serum cytokine levels in atopic dermatitis. Clin Exp Dermatol 2002; 27: 225-229.