β-Amyloid-derived pentapeptide RIIGL a inhibits Aβ 1-42 aggregation and toxicity

Biochemical and Biophysical Research Communications

Volumn 324, Issue 1, 2004, Pages 64-69

  Fülöp, Lívia ^a   Zarándi, Márta ^a   Datki, Zsolt ^a   Soós, Katalin ^a   Penke, Botond ^a,b  

^a UNIVERSITY OF SZEGED   (Hungary)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

Amyloid 31 34; Aggregation inhibitor; Alzheimer's disease; Amyloid aggregation; Toxic aggregates; Transmission electron microscopy

Indexed keywords

AMYLOID; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; ARGINYLISOLEUCYLISOLEUCYLGLYCYLLEUCINE A; CONGO RED; CYTOTOXIC AGENT; ISOLEUCYLISOLEUCYLGLYCYLLEUCINE A; PENTAPEPTIDE; PEPTIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; BINDING AFFINITY; CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; FIBER; HUMAN; HUMAN CELL; INHIBITION KINETICS; NEUROBLASTOMA CELL; PEPTIDE SYNTHESIS; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN BINDING; TOXICITY; TRANSMISSION ELECTRON MICROSCOPY;

AMYLOID BETA-PROTEIN; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL SURVIVAL; COLORING AGENTS; CONGO RED; HUMANS; NEUROBLASTOMA; OLIGOPEPTIDES; PEPTIDE FRAGMENTS;

EID: 4744345414     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.09.024     Document Type: Article

References (43)

1. J. El Khoury, S.E. Hickman, C.A. Thomas, L. Cao, S.C. Silverstein, and J.D. Loike Scavenger receptor-mediated adhesion of microglia to β-amyloid fibrils Nature 382 1996 716 719
2. D.M. Paresce, R.N. Ghosh, and F.R. Maxfield Microglia cells internalize aggregates of the Alzheimer's disease amyloid β-protein via a scavenger receptor Neuron 17 1996 553 565
3. S.D Yan, X. Chen, A.M. Schmidt, J. Brett, G. Goodman, Y.S. Zou, C.W. Scott, C. Caputo, T. Frappier, M.A. Smith, G. Perry, S.H. Yen, and D. Stern RAGE in Alzheimer's disease: a receptor mediated amyloid-β peptide-induced oxidant stress and neurotoxicity, and microglial activation Nature 382 1996 685 691
4. S.D. Yan, H. Zhu, J. Fu, S.F. Yan, A. Roher, W.W. Tourtellotte, T. Rajavashisth, X. Chen, G.C. Godman, D. Stern, and A.M. Schmidt Amyloid-beta peptide-receptor for advanced glycation endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: a proinflammatory pathway in Alzheimer's disease Proc. Natl. Acad. Sci. USA 94 1997 5296 5301
5. 2-Macroglobular protein as a β-amyloid peptide-binding plasma protein J. Neurochem. 69 1997 299 305
6. 2- Macroglobulin complexes with and mediates the endocytosis of β-amyloid peptide via cell surface low-density lipoprotein receptor-related protein J. Neurochem. 69 1997 1904 1911
7. T. Pillot, M. Goethals, J. Najib, C. Labeur, L. Lins, J. Chambaz, R. Brasseur, J. Vandekerckhove, and M. Rosseneu β-Amyloid peptide interacts specifically with the carboxy-terminal domain of human apolipoprotein E: relevance to Alzheimer's disease J. Neurochem. 72 1999 230 237
8. S.D. Yan, J. Fu, C. Soto, X. Chen, H. Zhu, F. Al-Mohanna, K. Collison, A. Zhu, E. Stern, T. Saido, M. Tohyjama, S. Ogawa, A. Roher, and D. Stern An intracellular protein that binds amyloid β-peptide and mediates neurotoxicity in Alzheimer's disease Nature 389 1997 689 695
9. 1-42 binds to α7 nicotinic acetylcholine receptor with high affinity: implications for Alzheimer's disease pathology J. Biol. Chem. 275 2000 5626 5632
10. 1-42 binds selectively and with picomolar affinity to α7 nicotinic acetylcholine receptors J. Neurochem. 75 2000 1155 1161
11. N. Arispe, E. Rojas, and H.B. Pollard Alzheimer disease amyloid-β protein forms calcium channels in bilayer membranes: blockade by tromethamine and aluminium Proc. Natl. Acad. Sci. USA 90 1993 561 571
12. M.X. Lin, T. Mirzabekov, and B.L. Kagan Channel formation by a neurotoxic prion protein fragment J. Biol. Chem. 272 1997 44 47
13. C. Behl, J.B. Davis, R. Lesley, and D. Schubert Hydrogen peroxide mediates amyloid-β toxicity Cell 77 1994 817 827
14. L.J. Hsu, Y. Sagara, A. Arroyo, E. Rockenstein, A. Sisk, M. Mallory, J. Wong, T. Takenouchi, M. Hashimoto, and E. Masliah α-Synuclein promotes mitochondrial deficit and oxidative stress Am. J. Pathol. 157 2000 401 410
15. M.P. Lambert, A.K. Barlow, B.A. Chromy, C. Edwards, R. Freed, M. Liosatos, T.E. Morgan, I. Rozovsky, B. Trommer, K.L. Viola, P. Wals, C. Zhang, C.E. Finch, G.A. Krafft, and W.L. Klein Diffusible, nonfibrillar ligands derived from A beta(1-42) are potent central nervous system neurotoxins Proc. Natl. Acad. Sci. USA 95 1998 6448 6453
16. K.N. Dahlgren, A.M. Manelli, W.B. Stine, L.K. Baker, G.A. Krafft, and M.J. LaDu Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability J. Biol. Chem. 277 2002 32046 32053
17. R. Bhatia, H. Lin, and R. Lal Fresh and globular amyloid beta protein (1-42) induces rapid cellular degeneration: evidence for AβP channel-mediated cellular toxicity FASEB J. 14 2000 1233 1243
18. T. Pillot, B. Drouet, S. Queillé, C. Labeur, J. Vandekerckhove, M. Rosseneu, M.P. Raymond, and J. Chambaz The nonfibrillar amyloid β-peptide induces apoptotic neuronal cell death: involvement of its C-terminal fusogenic domain J. Neurochem. 73 1999 1626 1634
19. D.M. Walsh, D.M. Hartley, Y. Kusumoto, Y. Fezoui, M.M. Condron, A. Lomakin, G.B. Benedek, D.J. Selkoe, and D.B. Teplow Amyloid β-protein fibrillogenesis J. Biol. Chem. 274 1999 25945 25952
20. J. Ghanta, C.L. Shen, L.L. Kiessling, and R.M. Murphy A strategy for designing inhibitors of β-amyloid toxicity J. Biol. Chem. 271 1996 29525 29528
21. C.M.M. Pallitto, J. Ghanta, P. Heinzelman, L.L. Kiessling, and R.M. Murphy Recognition sequence design for peptidyl modulators of β-amyloid aggregation and toxicity Biochemistry 38 1999 3570 3578
22. C. Soto Plaque buster strategies to inhibit amyloid formation in Alzheimer's disease Mol. Med. Today 5 1999 343 350
23. C. Soto Unfolding the role of protein misfolding in neurodegenerative diseases Nat. Rew. Neurosci. 4 2003 49 60
24. 31-35: reverse turn conformation and side-chain interactions revealed by X-ray diffraction J. Struct. Biol. 141 2003 156 170
25. R. Liu, C. McAllister, Y. Lyubchenko, and M.R. Sierks Residues 17-20 and 30-35 of beta-amyloid play critical roles in aggregation J. Neurosci. Res. 75 2004 162 171
26. B. Penke, L. Tóth, K. Soós, J. Varga, E.Z. Szabó, J. Márki-Zay, A. Baranyi, Amyloid peptides: the active center and the possible mechanism of action, starting and maintaining neuronal death, peptides, in: Proceedings of the 33rd European Peptide Symposium, Braga, 1994, pp. 101-102
27. X.Z. Yan, J.T. Qiao, Y. Dou, and Z.D. Qiao β-Amyloid peptide fragment 31-35 induces apoptosis in cultured cortical neurons Neuroscience 92 1999 177 184
28. I in rat astrocytes Biochem. Biophys. Res. Commun. 235 1997 479 481
29. T. Harkány, I. Ábrahám, G. Laskay, W. Timmerman, K. Jost, M. Zarándi, B. Penke, C. Nyakas, and P.G.M. Luiten Propionyl-IIGL tetrapeptide antagonizes β-amyloid excitotoxicity in rat nucleus basalis Neuroreport 10 1999 1693 1698
30. Z. Datki, A. Juhász, M. Gálfi, K. Soós, R. Papp, D. Zádori, and B. Penke Method for measuring neurotoxicity of aggregating polypeptides with the MTT assay on differentiated neuroblastoma cells Brain Res. Bull. 62 2003 223 229
31. W.E. Klunk, R.F. Jacob, and R.P. Mason Quantifying amyloid β-peptide (Aβ) aggregation using the congo red-Aβ (CR-Aβ) spectrophotometric assay Anal. Biochem. 266 1999 66 76
32. D.M. Walsh, A. Lomakin, G.B. Benedek, M.M. Condron, and D.B. Teplow Amyloid β-protein fibrillogenesis J. Biol. Chem. 272 1997 22364 22372
33. J.A. Hardy, and G.A. Higgins Alzheimer's disease: the amyloid cascade hypothesis Science 256 1992 184 185
34. J.A. Hardy, and D.J. Selkoe The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics Science 297 2002 353 356
35. P. Talaga β-Amyloid aggregation inhibitors for the treatment of Alzheimer's disease: dream or reality? Mini Rev. Med. Chem. 1 2001 175 186
36. M.M. Pallitto, J. Ghanta, P. Heinzelman, L.L. Kiessling, and R.M. Murphy Recognition sequence design for peptidyl modulators of beta-amyloid aggregation and toxicity Biochemistry 38 1999 3570 3578
37. C.W. Cairo, A. Strzelec, R.M. Murphy, and L.L. Kiessling Affinity-based inhibition of β-amyloid toxicity Biochemistry 41 2002 8620 8629
38. C. Soto, M.S. Kindy, M. Baumann, and B. Frangione Inhibition of Alzheimer's amyloidosis by peptides that prevent β-sheet conformation Biochem. Biophys. Res. Commun. 226 1996 672 680
39. C. Soto, E.M. Sigurdsson, L. Morelli, R.A. Kumar, E.M. Castano, and B. Frangione β-Sheet breaker peptides inhibit fibrillogenesis in rat brain model of amyloidosis: implications for Alzheimer's therapy Nat. Med. 4 1998 822 826
40. A. Monji, H. Utsumi, T. Ueda, T. Imoto, I. Yoshida, S. Hashioka, K. Tashiro, and N. Tashiro Amyloid-beta protein (A beta) (25-35) associated free radical generation is strongly influenced by the aggregational state of the peptides Life Sci. 70 2002 833 841
41. C.J. Pike, A.J. Walencewicz-Wasserman, J. Kosmoski, D.H. Cribbs, C.G. Glabe, and C.W. Cotman Structure-activity analyses of beta-amyloid peptides: contributions of the beta 25-35 region to aggregation and neurotoxicity J. Neurochem. 64 1995 253 265
42. A. Urani, P. Romieu, F.J. Roman, and T. Maurice Enhanced antidepressant effect of sigma (1) receptor agonists in beta(25-35)-amyloid peptide-treated mice Behav. Brain Res. 134 2002 239 247
43. I. Laczkó, S. Holly, Z. Kónya, K. Soós, J.L. Varga, M. Hollósi, and B. Penke Conformational mapping of amyloid peptides from the putative neurotoxic 25-35 region Biochem. Biophys. Res. Commun. 205 1994 120 126