Effects of glucagon on islet β cell function in patients with diabetes mellitus

Chinese Medical Sciences Journal

Volumn 23, Issue 2, 2008, Pages 117-120

  Wang, Tong ^a   Xiao, Xin Hua ^a   Li, Wen Hui ^a   Wang, Heng ^a   Sun, Qi ^a   Yuan, Tao ^a   Yang, Guo Hua ^a  

^a PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

Author keywords

C peptide; Diabetes mellitus; Glucagon; Islet cell function

Indexed keywords

C PEPTIDE; GLUCAGON; INSULIN; ORAL ANTIDIABETIC AGENT;

ADULT; ARTICLE; CELL FUNCTION; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; DIET RESTRICTION; DIET THERAPY; DRUG EFFECT; FEMALE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN TREATMENT; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET BETA CELL; PROVOCATION TEST; STATISTICAL SIGNIFICANCE;

EID: 47349121921     PISSN: 10019294     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1001-9294(09)60023-7     Document Type: Article

References (12)

1. Kjorholt C, Akerfeldt MC, Biden TJ, et al. Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of beta-cell differentiation and secretory function in the db/ db mouse model of diabetes. Diabetes 2005;54:2755-63.
2. Chen J, Saxena G, Mungrue IN, et al. Thioredoxin-interacting protein: a critical link between glucose toxicity and beta-cell ap-optosis. Diabetes 2008; 57:938-44.
3. Gjessing HJ, Reinhold B, Pedersen O. The effect of chronic hyperglycaemia on the islet B-cell responsiveness in newly diagnosed type 2 diabetes. Diabetes Med 1992; 9:601-4.
4. Iwasaki Y, Kondo K, Hasegawa H, et al. C-peptide response to glucagon in type 2 diabetes mellitus: a comparison with oral glucose tolerance test Diabetes Research 1994; 25:129-37.
5. Qian RL. Diabetes clinic manual. Beijing: Beijing Medical University Press; 2000. p.66-71.
6. World Health Organization. Definition, Diagnosis and Classification of Diabetes Mellitus and its Complications. Report of a WHO Consultation. WHO/NCD/NCS/99.2. Geneva: WHO, 1999.
7. Bonser AM, Garcia-Webb P. C-peptide measurement: method and clinical utility. Crit Rev Clin Lab Sci 1984; 19:297-352.
8. Polonsky KS, Rubenstinein AH. C-peptide as measure of the secretion and hepatic extraction of insulin. Pitfalls and limitations. Diabetes 1984; 33:486-93.
9. Faber OK, Binder C. C-peptide response to glucagons. A test for the residual β cell function in diabetes mellitus. Diabetes 1977; 26:605-10.
10. Scheen AJ, Castillo MJ, Lefebvre PJ. Assessment of residual insulin secretion in diabetic patients using the intravenous glucagon stimulatory test: methodological aspects and clinical applications. Diabetes Metab 1996; 22:397-406.
11. Taha DR, Castells S, Umpaichitra V, et al. Beta-cell response to intravenous glucagon in African-American and Hispanic children with type 2 diabetes mellitus. J Pediatr Endocrinol Metab 2002; 15:59-67.
12. Vahlkamp T, Lutjens A, Nauta EH. The glucagon-stimulated C-peptide test: an aid in classification of patients with diabetes mellitus. Neth J Med 1990; 36:196-9.