The use of a semiocclusive dressing reduces epidermal inflammatory cytokine expression and mitigates dermal proliferation and inflammation in a rat incisional model

Wound Repair and Regeneration

Volumn 16, Issue 4, 2008, Pages 568-575

  Kloeters, Oliver ^a,b   Schierle, Clark ^a   Tandara, Andrea ^a   Mustoe, Thomas A ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 1ALPHA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE RELEASE; EPIDERMIS; FEMALE; HISTOLOGY; INFLAMMATION; MITOSIS RATE; MOLECULAR BIOLOGY; NONHUMAN; OCCLUSIVE DRESSING; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; SKIN INCISION; SURGICAL TAPE; WOUND;

ANIMALS; CELL PROLIFERATION; FEMALE; INFLAMMATION MEDIATORS; INTERLEUKIN-1; OCCLUSIVE DRESSINGS; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SKIN; TUMOR NECROSIS FACTOR-ALPHA; WOUND HEALING;

EID: 47349099880     PISSN: 10671927     EISSN: 1524475X     Source Type: Journal    
DOI: 10.1111/j.1524-475X.2008.00404.x     Document Type: Article

References (36)

1. Singer AJ, Clark RA. Cutaneous wound healing. N Engl J Med 1999 341:738 46.
2. Desmouliere A, Redard M, Darby I, Gabbiani G. Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar. Am J Pathol 1995 146:56 66.
3. Garner WL. Epidermal regulation of dermal fibroblast activity. Plast Reconstr Surg 1998 102:135 9.
4. Mustoe TA, Cooter RD, Gold MH, Hobbs FD, Ramelet AA, Shakespeare PG, Stella M, Teot L, Wood FM, Ziegler UE. International clinical recommendations on scar management. Plast Reconstr Surg 2002 110:560 71.
5. Mustoe TA. Scars and keloids. BMJ 2004 328:1329 30.
6. Su CW, Alizadeh K, Boddie A, Lee RC. The problem scar. Clin Plast Surg 1998 25:451 65.
7. Atiyeh BS, El-Musa KA, Dham R. Scar quality and physiologic barrier function restoration after moist and moist-exposed dressings of partial-thickness wounds. Dermatol Surg 2003 29:14 20.
8. Svensjo T, Pomahac B, Yao F, Slama J, Eriksson E. Accelerated healing of full-thickness skin wounds in a wet environment. Plast Reconstr Surg 2000 106:602 12.
9. Winter GD. Formation of the scab and the rate of epithelization of superficial wounds in the skin of the young domestic pig. Nature 1962 193:293 4.
10. Poston J. The use of silicone gel sheeting in the management of hypertrophic and keloid scars. J Wound Care 2000 9:10 6.
11. Sawada Y, Sone K. Hydration and occlusion treatment for hypertrophic scars and keloids. Br J Plast Surg 1992 45:599 603.
12. Saulis AS, Chao J, Telser A, Mogford JE, Mustoe TA. Silicone occlusive products in the treatment of hypertrophic scar in the rabbit ear hypertrophic scar model. Aesthetic Surg J 2002 22:147 53.
13. Kloeters O, Kim JYS, Mustoe TA. Occlusive dressing reduces inflammatory response and alters connexin expression in a rat incisional model. Wound Repair Regen 2005 13:A26.
14. Kloeters O, Tandara A, Mustoe TA. The hypertrophic scar model in the rabbit ear - a reproducible model for studying scar tissue behavior with new observations on silicone gel sheeting for scar reduction. Wound Repair Regen 2007 15:S40 5.
15. Tandara AA, Mustoe TA, Mogford JE. Impact of hydration on MMP Activity. Wound Repair Regen 2004 12.
16. Atkinson JA, McKenna KT, Barnett AG, McGrath DJ, Rudd M. A randomized, controlled trial to determine the efficacy of paper tape in preventing hypertrophic scar formation in surgical incisions that traverse Langer's skin tension lines. Plast Reconstr Surg 2005 116:1648 56.
17. Mustoe TA, Kloeters O. Discussion. Atkinson JA, McKenna KT, Barnett AG, McGrath DJ, Rudd M. A randomized, controlled trial to determine the efficacy of paper tape in preventing hypertrophic scar formation in surgical incisions that traverse Langer's skin tension lines. Plast Reconstr Surg 2005 116:1648 56, discussion 1657-58.
18. Suetake T, Sasai S, Zhen YX, Tagami H. Effects of silicone gel sheet on the stratum corneum hydration. Br J Plast Surg 2000 53:503 7.
19. Tandara AA, Kloeters O, Mustoe TA. Reduction of scarring by silicone in the rabbit ear. Model Wound Repair Regen 2005 13:A4.
20. Suetake T, Sasai S, Zhen YX, Ohi T, Tagami H. Functional analyses of the stratum corneum in scars. Sequential studies after injury and comparison among keloids, hypertrophic scars, and atrophic scars. Arch Dermatol 1996 132:1453 8.
21. Chang CC, Kuo YF, Chiu MS, et al. Hydration, not silicone, modulates the effects of keratinocytes on fibroblasts. J Surg Res 1995 59:705 11.
22. Mustoe TA, Weber DA, Krukowski M. Enhanced healing of cutaneous wounds in rats using beads with positively charged surfaces. Plast Reconstr Surg 1992 89:891 7.
23. Kloeters O, Jia SX, Roy N, Schultz GS, Leinfellner G, Mustoe TA. Alteration of Smad3 signaling in ischemic rabbit dermal ulcer wounds. Wound Repair Regen 2007 15:341 9.
24. Madison KC. Barrier function of the skin: "la raison d'être" of the epidermis. J Invest Dermatol 2003 121:231 41.
25. Denning MF. Epidermal keratinocytes: regulation of multiple cell phenotypes by multiple protein kinase C isoforms. Int J Biochem Cell Biol 2004 36:1141 6.
26. Tandara AA, Kloeters O, Mogford JE, Mustoe TA. Hydrated keratinocytes reduce collagen-synthesis by fibroblasts via paracrine mechanisms. Wound Repair Regen 2007 15:497 504.
27. Uchi H, Terao H, Koga T, Furue M. Cytokines and chemokines in the epidermis. J Dermatol Sci 2000 24 (Suppl. 1):S29 38.
28. Kirnbauer R, Kock A, Schwarz T, Urbanski A, Krutmann J, Borth W, Damm D, Shipley G, Ansel JC, Luger TA. IFN-beta 2, B cell differentiation factor 2, or hybridoma growth factor (IL-6) is expressed and released by human epidermal cells and epidermoid carcinoma cell lines. J Immunol 1989 142:1922 8.
29. Griffiths CE, Barker JN, Kunkel S, Nickoloff BJ. Modulation of leucocyte adhesion molecules, a T-cell chemotaxin (IL-8) and a regulatory cytokine (TNF-alpha) in allergic contact dermatitis (rhus dermatitis). Br J Dermatol 1991 124:519 26.
30. Matsushima K, Morishita K, Yoshimura T, Lavu S, Kobayashi Y, Lew W, Appella E, Kung HF, Leonard EJ, Oppenheim Molecular cloning of a human monocyte-derived neutrophil chemotactic factor (MDNCF) and the induction of MDNCF mRNA by interleukin 1 and tumor necrosis factor. J Exp Med 1988 167:1883 93.
31. Kupper TS, Lee F, Birchall N, Clark S, Dower S. Interleukin 1 binds to specific receptors on human keratinocytes and induces granulocyte macrophage colony-stimulating factor mRNA and protein. A potential autocrine role for interleukin 1 in epidermis. J Clin Invest 1988 82:1787 92.
32. Wood LC, Jackson SM, Elias PM, Grunfeld C, Feingold KR. Cutaneous barrier perturbation stimulates cytokine production in the epidermis of mice. J Clin Invest 1992 90:482 7.
33. Wood LC, Feingold KR, Sequeira-Martin SM, Elias PM, Grunfeld C. Barrier function coordinately regulates epidermal IL-1 and IL-1 receptor antagonist mRNA levels. Exp Dermatol 1994 3:56 60.
34. Tsai JC, Feingold KR, Crumrine D, Wood LC, Grunfeld C, Elias PM. Permeability barrier disruption alters the localization and expression of TNF alpha/protein in the epidermis. Arch Dermatol Res 1994 286:242 8.
35. Ashida Y, Ogo M, Denda M. Epidermal interleukin-1 alpha generation is amplified at low humidity: implications for the pathogenesis of inflammatory dermatoses. Br J Dermatol 2001 144:238 43.
36. Wood LC, Elias PM, Sequeira-Martin SM, Grunfeld C, Feingold KR. Occlusion lowers cytokine mRNA levels in essential fatty acid-deficient and normal mouse epidermis, but not after acute barrier disruption. J Invest Dermatol 1994 103:834 8.