Radiolabeled Arginine-Glycine-Aspartic Acid Peptides to Image Angiogenesis in Swine Model of Hibernating Myocardium

JACC: Cardiovascular Imaging

Volumn 1, Issue 4, 2008, Pages 500-510

  Johnson, Lynne L ^a   Schofield, Lorraine ^b   Donahay, Tammy ^b   Bouchard, Mark ^b   Poppas, Athena ^b   Haubner, Roland ^c,d  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b RHODE ISLAND HOSPITAL   (United States)

^c INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^d TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

angiogenesis; cyclo RGD peptides; integrins; myocardial hibernation; VEGF

Indexed keywords

ARGINYLGLYCYLASPARTIC ACID; FLUORINE 18; INDIUM 111; IODINE 123; LECTIN; RADIOPHARMACEUTICAL AGENT; RP 748; SODIUM CHLORIDE; THALLIUM 201; VASCULOTROPIN 165; VITRONECTIN RECEPTOR;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL WALL; CAPILLARY DENSITY; CONTROLLED STUDY; CORONARY ARTERY CIRCUMFLEX BRANCH; CORRELATION ANALYSIS; DATA ANALYSIS; DIAGNOSTIC IMAGING; DRUG ADMINISTRATION ROUTE; DRUG EFFICACY; DRUG MONITORING; DRUG TARGETING; ECHOCARDIOGRAPHY; ENDOMYOCARDIAL DRUG ADMINISTRATION; ENDOTHELIUM CELL; EXTRACELLULAR MATRIX; FIBROSIS; HEART MUSCLE BLOOD FLOW; ISOTOPE LABELING; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MALE; MYOCARDIAL HIBERNATION; NON INVASIVE PROCEDURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; STAINING; SWINE;

ANIMALS; CAPILLARIES; CORONARY ANGIOGRAPHY; CORONARY CIRCULATION; CORONARY STENOSIS; DISEASE MODELS, ANIMAL; ECHOCARDIOGRAPHY; FIBROSIS; GENE THERAPY; GENE TRANSFER TECHNIQUES; GLUCOSIDES; HUMANS; INTEGRIN ALPHAVBETA3; MALE; MYOCARDIUM; NEOVASCULARIZATION, PHYSIOLOGIC; OLIGOPEPTIDES; RADIOPHARMACEUTICALS; SWINE; TIME FACTORS; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 47349088394     PISSN: 1936878X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jcmg.2008.05.002     Document Type: Article

References (33)

1. Henry T.D., Annex B.H., McKendall G.R., et al. The VIVA trial: Vascular endothelial growth factor in Ischemia for Vascular Angiogenesis. Circulation 107 (2003) 1359-1365
2. Symes J.F., Losordo D.W., Vale P.R., et al. Gene therapy with vascular endothelial growth factor for inoperable coronary artery disease. Ann Thorac Surg 68 (1999) 830-837
3. Vale P.R., Losordo D.W., Milliken C.E., et al. Randomized, single-blind, placebo-controlled pilot study of catheter-based myocardial gene transfer for therapeutic angiogenesis using left ventricular electromechanical mapping in patients with chronic myocardial ischemia. Circulation 101 (2001) 2138-2143
4. Losordo D.W., Vale P.R., Hendel R.C., et al. Phase placebo-controlled double-blind, dose-escalating trial of myocardial vascular endothelial growth factor 2 gene transfer by catheter delivery in patients with chronic myocardial ischemia. Circulation 105 (2002) 2012-2018
5. Kastrup J., Jorgensen E., Ruck A., et al. Direct intramyocardial plasmid vascular endothelial growth factor-A165 gene therapy in patients with stable severe angina pectoris. J Am Coll Cardiol 45 (2005) 982-988
6. Grines C.L., Watkins M.W., Helmer G., et al. Gene therapy (AGENT) trial in patients with stable angina pectoris. Circulation 105 (2002) 1291-1297
7. Grines C.L., Watkins M.W., Mahmarian J.J., et al. A randomized, double-blind, placebo-controlled trial of Ad5FGDF-4 gene therapy and its effect on myocardial perfusion in patients with stable angina. J Am Coll Cardiol 42 (2003) 1339-1347
8. Stewart D.J., Hilton J.D., Arnold J.M.O., et al. Angiogenic gene therapy in patients with nonrevascularizable ischemic heart disease: a phase 2 randomized, controlled trial of AdVEGF (ADVEFG121) versus maximum medical treatment. Gene Ther 13 (2006) 1503-1511
9. Payne T.R., Oshima H., Okada M., et al. A Relationship between vascular endothelial growth factor, angiogenesis, and cardiac repair after muscle stem cell transplantation into ischemic hearts. J Am Coll Cardiol 50 (2007) 1677-1685
10. Vandervelde S., van Luyn M.J.A., and Harmsen M.C. Signaling factors in stem cell-mediated repair of infarcted myocardium. J Mol Cell Cardiol 39 (2005) 363-376
11. Xiong J.P., Stehle T., Diefenbach B., et al. Crystal structure of the extracellular segment of integrin aVβ3. Science 294 (2001) 339-346
12. Giancotti F.G., and Ruoslahti E. Integrin signaling. Science 285 (1999) 1028-1032
13. Senger D.R., Claffey K.P., Benes J.E., Perruzzi C.A., Segiou A.P., and Detmar M. Angiogenesis promoted by vascular endothelial growth factor: regulation through a1β1 and a2β1 integrins. Proc Natl Acad Sci U S A 94 (1997) 13612-13617
14. Byzova T.V., Goldman C.K., Pampori N., et al. A mechanism for modulation of cellular responses to VEGF: activation of the integrins. Mol Cell 6 (2000) 851-860
15. Tsou R., and Isik F.F. Integrin activation is required for VEGF and FGF receptor protein presence on human microvascular endothelial cells. Mol Cell Biochem 224 (2001) 81-89
16. Bayless K.J., Salazar R., and Davis G.E. RGD-dependent vacuolation and lumen formation observed during endothelial cell morphogenesis in three-dimensional fibrin matrices involves the avβ3 and a5β1 integrins. Am J Pathol 156 (2000) 1673-1683
17. Haubner R. avβ3-Integrin imaging: a new approach to characterize angiogenesis?. Eur J Nucl Med Mol Imaging 33 (2006) S54-S63
18. Haubner R., Wester H.J., Burkhart F., et al. Glycosylated RGD-containing peptides: tracer for tumor targeting and angiogenesis imaging with improved biokinetics. J Nucl Med 42 (2001) 326-336
19. 18F] Galacto-RGD: synthesis, radiolabeling, metabolic stability, and radiation dose estimates. Bioconjug Chem 15 (2004) 61-69
20. 18F-labeled RGD-containing glycopeptides and positron emission tomography. Cancer Res 61 (2001) 1781-1785
21. Thambar S.T., Schofield L., Poppas A., Bouchard M., Williams D.O., and Johnson L.L. Validation of R wave voltage endomyocardial mapping to assess myocardial fibrosis: comparison with thallium and dobutamine echocardiography in a swine model. J Interv Cardiol 16 (2003) 23-31
22. Hale S.L., Alker K.F., and Kloner R.A. Evaluation of nonradioactive, colored microspheres for measurement of regional myocardial blood flow in dogs. Circulation 78 (1988) 428-434
23. Johnson L.L., Schofield L., Mastrofrancesco P., Donahay T., Farb A., and Khaw B.A. Technetium-99m glucarate uptake in a swine model of limited flow plus increased demand. J Nucl Cardiol 7 (2000) 590-598
24. Winter P.M., Morawski A.M., Caruthers S.D., et al. Molecular imaging of angiogenesis in early-stage atherosclerosis with avβ3-integrin-targeted nanoparticles. Circulation 108 (2003) 2270-2274
25. Sadeghi M.M., Krassilnikova S., Zhang J., et al. Detection of injury-induced vascular remodeling by targeting activated avβ3 integrin in vivo. Circulation 110 (2004) 84-90
26. Hua J., Dobrucki L.W., Sadeghi M.M., et al. Noninvasive imaging of angiogenesis with a 99m Tc-labeled peptide targeted at avβ3 integrin after murine hindlimb ischemia. Circulation 111 (2005) 3255-3260
27. Meoli D.F., Sadeghi M.M., Krassilnikova S., et al. Noninvasive imaging of myocardial angiogenesis following experimental myocardial infarction. J Clin Invest 113 (2004) 1684-1691
28. Wagner B., Anton M., Nekolla S.G., et al. Noninvasive characterization of myocardial molecular interventions by integrated positron emission tomography and computed tomography. J Am Coll Cardiol 48 (2006) 2107-2115
29. Ylä-Herttuala S., Rissanen T.T., Vajanto I., and Hartikainen J. Vascular endothelial growth factors. J Am Coll Cardiol 49 (2007) 1015-1026
30. Fallavollita J.A., Logue M., and Canty J.M. Stability of hibernating myocardium in pigs with a chronic left anterior descending coronary artery stenosis: absence of progressive fibrosis in the setting of stable reductions in flow, function and coronary flow reserve. J Am Coll Cardiol 37 (2001) 1989-1995
31. Vale P.R., Losordo D.W., Tkebuchave T., Chen D., Milliken C.E., and Isner J.M. Catheter-based myocardial gene transfer utilizing nonfluoroscopic electromechanical left ventricular mapping. J Am Coll Cardiol 34 (1999) 246-254
32. Vale P.R., Losordo D.W., Milliken C.E., et al. Left ventricular electromechanical mapping to assess efficacy of ph VEGF 165 gene transfer for therapeutic angiogenesis in chronic myocardial ischemia. Circulation 102 (2000) 965-974
33. Tio R.A., Tkebuchava T., Scheuermann T.H., et al. Intramyocardial gene therapy with naked deoxyribonucleic acid encoding vascular endothelial growth factor improves collateral flow to ischemic myocardium. Hum Gene Ther 10 (1999) 2953-660