Re-established micturition reflexes show differential activation patterns after lumbosacral ventral root avulsion injury and repair in rats

Experimental Neurology

Volumn 212, Issue 2, 2008, Pages 291-297

  Chang, Hui Yi ^a   Havton, Leif A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Bladder; Cauda equina; Cystometrogram; Electromyography; External urethral sphincter

Indexed keywords

AMPLITUDE MODULATION; ANIMAL EXPERIMENT; ARTICLE; AVULSION INJURY; BLADDER CONTRACTION; BLADDER SPHINCTER; CONTROLLED STUDY; CONUS MEDULLARIS; CYSTOMETRY; ELECTROMYOGRAPHY; FEMALE; LUMBOSACRAL SPINE; MICTURITION; MICTURITION REFLEX; NONHUMAN; PRIORITY JOURNAL; RAT; SHAM PROCEDURE; SPINAL CORD INJURY; SPINAL CORD SURGERY; URODYNAMICS; VENTRAL ROOT;

ANIMALS; CAUDA EQUINA; DISEASE MODELS, ANIMAL; ELECTROMYOGRAPHY; FEMALE; LUMBOSACRAL REGION; RADICULOPATHY; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; REPLANTATION; TRAUMA SEVERITY INDICES; URINARY BLADDER, NEUROGENIC; URINATION;

EID: 47349087887     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2008.03.021     Document Type: Article

References (29)

1. Beric A., and Light J.K. Function of the conus medullaris and cauda equina in the early period following spinal cord injury and the relationship to recovery of detrusor function. J. Urol. 148 (1992) 1845-1848
2. Bigbee A., Hoang T.X., and Havton L.A. At-level neuropathic pain is induced by lumbosacral ventral root avulsion injury and ameliorated by root reimplantation into the spinal cord. Exp. Neurol. 204 (2007) 273-282
3. Callsen-Cencic P., and Mense S. Abolition of cystitis-induced bladder instability by local spinal cord cooling. J. Urol. 160 (1998) 236-241
4. Chang H.Y., Cheng C.L., Chen J.J., and de Groat W.C. Roles of glutamatergic and serotonergic mechanisms in reflex control of the external urethral sphincter in urethane-anesthetized female rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 291 (2006) R224-R234
5. Chang H.Y., Cheng C.L., Chen J.J., and de Groat W.C. Serotonergic drugs and spinal cord transections indicate that different spinal circuits are involved in external urethral sphincter activity in rats. Am. J. Physiol. Renal Physiol. 292 (2007) F1044-F1053
6. Cheng C.L., Chai C.Y., and de Groat W.C. Detrusor-sphincter dyssynergia induced by cold stimulation of the urinary bladder of rats. Am. J. Physiol. 272 (1997) R1271-R1282
7. Cheng C.L., and de Groat W.C. The role of capsaicin-sensitive afferent fibers in the lower urinary tract dysfunction induced by chronic spinal cord injury in rats. Exp. Neurol. 187 (2004) 445-454
8. de Groat W.C. Integrative control of the lower urinary tract: preclinical perspective. Br. J. Pharmacol. 147 (2006) S25-S40
9. Fowler C.J. Neurological disorders of micturition and their treatment. Brain 122 (1999) 1213-1231
10. Herdegen T., Skene P., and Bähr M. The c-Jun transcription factor - bipotential mediator of neuronal death, survival and regeneration. Trends Neurosci. 20 (1997) 227-231
11. Hoang T.X., Nieto J.H., Tillakaratne N.J., and Havton L.A. Autonomic and motor neuron death is progressive and parallel in a lumbosacral ventral root avulsion model of cauda equina injury. J. Comp. Neurol. 467 (2003) 477-486
12. Hoang T.X., Pikov V., and Havton L.A. Functional reinnervation of the rat lower urinary tract after cauda equina injury and repair. J. Neurosci. 26 (2006) 8672-8679
13. Hoang T.X., Nieto J.H., Dobkin B.H., Tillakaratne N.J., and Havton L.A. Acute implantation of an avulsed lumbosacral ventral root into the rat conus medullaris promotes neuroprotection and graft reinnervation by autonomic and motor neurons. Neuroscience 138 (2006) 1149-1160
14. Hoang T.X., and Havton L.A. Novel repair strategies to restore bladder function following cauda equina/conus medullaris injuries. Prog. Brain Res. 152 (2006) 195-204
15. Kerns J.M., Damaser M.S., Kane J.M., Sakamoto K., Benson J.T., Shott S., and Brubaker L. Effects of pudendal nerve injury in the female rat. Neurourol. Urodyn. 19 (2000) 53-69
16. Kruse M.N., Belton A.L., and de Groat W.C. Changes in bladder and external urethral sphincter function after spinal cord injury in the rat. Am. J. Physiol. Regul. Integr. Comp. Physiol. 264 (1993) R1157-R1163
17. Kruse M.N., and de Groat W.C. Spinal pathways mediate coordinated bladder urethral sphincter activity during reflex micturition in decerebrate and spinalized neonatal rats. Neurosci. Lett. 152 (1993) 141-144
18. Ma J., Novikov L.N., Wiberg M., and Kellerth J.O. Delayed loss of spinal motoneurons after peripheral nerve injury in adult rats: a quantitative morphological study. Exp. Brain Res. 139 (2001) 216-223
19. Maggi C.A., Giuliani S., Santicioli P., and Meli A. Analysis of factors involved in determining urinary bladder voiding cycle in urethan-anesthetized rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 251 (1986) R250-R257
20. Maggi C.A., Santicioli P., and Meli A. The nonstop transvesical cystometrogram in urethane-anesthetized rats: a simple procedure for quantitative studies on the various phases of urinary bladder voiding cycle. J. Pharmacol. Methods 15 (1986) 157-167
21. Nadelhaft I., and Booth A.M. The location and morphology of preganglionic neurons and the distribution of visceral afferents from the rat pelvic nerve: a horseradish peroxidase study. J. Comp. Neurol. 226 (1984) 238-245
22. Nieto J.H., Hoang T.X., Warner E.A., Franchini B.T., Westerlund U., and Havton L.A. Titanium mesh implantation-a method to stabilize the spine and protect the spinal cord following a multilevel laminectomy in the adult rat. J. Neurosci. Methods 147 (2005) 1-7
23. Pavlakis A.J., Siroky M.B., Goldstein I., and Krane R.J. Neurourologic findings in conus medullaris and cauda equina injury. Arch. Neurol. 40 (1983) 570-573
24. Piehl F., Tabar G., and Cullheim S. Expression of NMDA receptor mRNAs in rat motoneurons is down-regulated after axotomy. Eur. J. Neurosci. 7 (1995) 2101-2110
25. Schalow G., Bersch U., Michel D., and Koch H.G. Detrusor-sphincteric dyssynergia in humans with spinal cord lesions may be caused by a loss of stable phase relations between and within oscillatory firing neuronal networks of the sacral micturition center. J. Auton. Nerv. Syst. 52 (1995) 181-202
26. Schrøder H.D. Organization of the motoneurons innervating the pelvic muscles of the male rat. J. Comp. Neurol. 192 (1980) 567-587
27. Sindou M., Mertens P., and Wael M. Microsurgical DREZotomy for pain due to spinal cord and/or cauda equina injuries: long-term results in a series of 44 patients. Pain 92 (2001) 159-171
28. Taylor T.K., and Coolican M.J. Injuries of the conus medullaris. Paraplegia 26 (1988) 393-400
29. Vanden Noven S., Wallace N., Muccio D., Turtz A., and Pinter M.J. Adult spinal motoneurons remain viable despite prolonged absence of functional synaptic contact with muscle. Exp. Neurol. 123 (1993) 147-156