Discovery of potent, orally bioavailable small-molecule inhibitors of the human CCR2 receptor

ChemMedChem

Volumn 3, Issue 4, 2008, Pages 660-669

  Doyon, Julien ^a   Coesemans, Erwin ^a   Boeckx, Staf ^a   Buntinx, Mieke ^a   Hermans, Bart ^a   Van Wauwe, Jean P ^a   Gilissen, Ron A H J ^a   De Groot, Alex H J ^a   Corens, David ^a   Van Lommen, Guy ^a  

^a JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

Bioisosteres; CCR2; Inhibitors; MCP 1; Thioimidazoles

Indexed keywords

CALCIUM; CCL2 PROTEIN, HUMAN; CCR2 PROTEIN, HUMAN; CHEMOKINE RECEPTOR CCR2; IMIDAZOLE DERIVATIVE; MONOCYTE CHEMOTACTIC PROTEIN 1;

ANIMAL; ARTICLE; BIOAVAILABILITY; CELL LINE; DRUG ANTAGONISM; DRUG STABILITY; HUMAN; MALE; METABOLISM; ORAL DRUG ADMINISTRATION; RAT; SPRAGUE DAWLEY RAT; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CALCIUM; CELL LINE; CHEMOKINE CCL2; DRUG STABILITY; HUMANS; IMIDAZOLES; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CCR2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 47249165159     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.200700276     Document Type: Conference Paper

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