The rectal tonsil: A reactive lymphoid proliferation that may mimic lymphoma

American Journal of Surgical Pathology

Volumn 32, Issue 7, 2008, Pages 1075-1079

  Farris, Alton B ^a,b   Lauwers, Gregory Y ^a,b   Ferry, Judith A ^a,b   Zukerberg, Lawrence R ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Lymphoid follicular proctitis; Lymphoid hyperplasia; Lymphoid polyp; Lymphoma; Rectal tonsil; Rectum

Indexed keywords

ABDOMINAL PAIN; ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL FEATURE; CONSTIPATION; CONTROLLED STUDY; CRYPT CELL; FEMALE; FOLLICULAR DENDRITIC CELL; HEMATOCHEZIA; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; INFANT; LAMINA PROPRIA; LYMPH FOLLICLE; LYMPHOCYTE; LYMPHOID TISSUE; LYMPHOMA; MALE; POLYP; RECTAL TONSIL; RECTUM HEMORRHAGE; RECTUM INJURY; RECTUM TUMOR; DIFFERENTIAL DIAGNOSIS; GASTROINTESTINAL ENDOSCOPY; LYMPHOPROLIFERATIVE DISEASE; METABOLISM; MIDDLE AGED; PATHOLOGY; RECTUM;

BIOLOGICAL MARKER;

ADULT; BIOLOGICAL MARKERS; DIAGNOSIS, DIFFERENTIAL; ENDOSCOPY, GASTROINTESTINAL; FEMALE; HUMANS; INFANT; LYMPHOCYTES; LYMPHOID TISSUE; LYMPHOMA; LYMPHOPROLIFERATIVE DISORDERS; MALE; MIDDLE AGED; RECTUM;

EID: 47249164394     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0b013e318162c3ec     Document Type: Article

References (23)

1. Byrne WJ, Jimenez JF, Euler AR, et al. Lymphoid polyps (focal lymphoid hyperplasia) of the colon in children. Pediatrics. 1982;69: 598-600.
2. Damaj G, Verkarre V, Delmer A, et al. Primary follicular lymphoma of the gastrointestinal tract: a study of 25 cases and a literature review. Ann Oncol. 2003;14:623-629.
3. Das KM, Morecki R, Nair P, et al. Idiopathic proctitis. I. The morphology of proximal colonic mucosa and its clinical significance. Am J Dig Dis. 1977;22:524-528.
4. Flejou JF, Potet F, Bogomoletz WV, et al. Lymphoid follicular proctitis. A condition different from ulcerative proctitis? Dig Dis Sci. 1988;33:314-320.
5. Folley JH. Current concepts: ulcerative proctitis. N Engl J Med. 1970;282:1362-1364.
6. Hummel KP. The structure and development of the lymphatic tissue in the intestine of the Albino Rat. Am J Anat. 1935;57:351.
7. Kealy WF. Colonic lymphoid-glandular complex (microbursa): nature and morphology. J Clin Pathol. 1976;29:241-244.
8. Kodama T, Ohshima K, Nomura K, et al. Lymphomatous polyposis of the gastrointestinal tract, including mantle cell lymphoma, follicular lymphoma and mucosa-associated lymphoid tissue lymphoma. Histopathology. 2005;47:467-478.
9. Kohno S, Ohshima K, Yoneda S, et al. Clinicopathological analysis of 143 primary malignant lymphomas in the small and large intestines based on the new WHO classification. Histopathology. 2003;43:135-143.
10. Kraehenbuhl JP, Neutra MR. Epithelial M cells: differentiation and function. Annu Rev Cell Dev Biol. 2000;16:301-332.
11. Langman JM, Rowland R. The number and distribution of lymphoid follicles in the human large intestine. J Anat. 1986; 149:189-194.
12. Lloyd J, Darzi A, Teare J, et al. A solitary benign lymphoid polyp of the rectum in a 51 year old woman. J Clin Pathol. 1997;50: 1034-1035.
13. McNicholas T, Brereton RJ, Raafat F. Lymphoid polyps of the rectum. J Pediatr Gastroenterol Nutr. 1985;4:297-302.
14. Misdraji J, Harris NL, Ferry JA. Follicular lymphoma of the gastrointestinal tract (abstract). Ann Oncol. 2007;18(S):109.
15. Morson BC, Dawson IMP, Day DW, et al. Gastrointestinal Pathology. London, Oxford: Blackwell Scientific Publications; 1990.
16. Ogra PL. Mucosal immunity: some historical perspective on host-pathogen interactions and implications for mucosal vaccines. Immunol Cell Biol. 2003;81:23-33.
17. O'Leary AD, Sweeney EC. Lymphoglandular complexes of the colon: structure and distribution. Histopathology. 1986;10:267-283.
18. Ranchod M, Lewin KJ, Dorfman RF. Lymphoid hyperplasia of the gastrointestinal tract. A study of 26 cases and review of the literature. Am J Surg Pathol. 1978;2:383-400.
19. Rotterdam H, Sommers SC. Biopsy Diagnosis of the Digestive Tract. New York: Raven Press; 1979:556-557.
20. Sakugawa ST, Yoshino T, Nakamura S, et al. API2-MALT1 fusion gene in colorectal lymphoma. Mod Pathol. 2003;16:1232-1241.
21. Shami VM, Waxman I. Lymphoid follicular proctitis mimicking rectal lymphoma: diagnosis by EMR. Gastrointest Endosc. 2004;60: 648-652.
22. Toyoda H, Yamaguchi M, Uemura Y, et al. Successful treatment of lymphoid follicular proctitis with sulfasalazine suppositories. Am J Gastroenterol. 2000;95:2403-2404.
23. Weller MH, Feldman PS. Benign lymphoid polyps of the rectum. Pediatr Radiol. 1975;3:209-212.