The use of 1-aminobenzotriazole in differentiating the role of CYP-mediated first pass metabolism and absorption in limiting drug oral bioavailability: A case study

Drug Metabolism Letters

Volumn 2, Issue 2, 2008, Pages 120-124

  El Kattan, Ayman F ^a   Poe, Julie ^a   Buchholz, Lisa ^a   Thomas, Hazden V ^a   Brodfuehrer, Joanne ^a   Clark, Alan ^a  

^a PFIZER INC   (United States)

Author keywords

1 aminobenzotriazole; Bioavailability; First pass effect absorption

Indexed keywords

1 AMINOBENZOTRIAZOLE; CYTOCHROME P450; MONOCLONAL ANTIBODY;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG DOSAGE FORM COMPARISON; DRUG HALF LIFE; DRUG METABOLISM; ENZYME INHIBITION; FIRST PASS EFFECT; LIQUID CHROMATOGRAPHY; MALE; MEAN RESIDENCE TIME; NONHUMAN; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE; TANDEM MASS SPECTROMETRY; TIME;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CHROMATOGRAPHY, LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; DRUG INTERACTIONS; ENZYME INHIBITORS; HALF-LIFE; INJECTIONS, INTRAVENOUS; MALE; PHARMACEUTICAL PREPARATIONS; RATS; RATS, SPRAGUE-DAWLEY; TANDEM MASS SPECTROMETRY; TISSUE DISTRIBUTION; TRIAZOLES;

ANIMALIA; RATTUS;

EID: 47249159896     PISSN: 18723128     EISSN: None     Source Type: Journal    
DOI: 10.2174/187231208784041004     Document Type: Article

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