Psychosocial factors, biological mediators, and cancer prognosis: A new look at an old story

Current Opinion in Oncology

Volumn 20, Issue 4, 2008, Pages 386-392

  Gidron, Yori ^a   Ronson, Alain ^b  

^a BRUNEL UNIVERSITY   (United Kingdom)

^b JULES BORDET INSTITUTE   (Belgium)

Author keywords

Biological mechanisms; Prognosis; Psychoneuroimmunology; Psychosocial factors

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BIOLOGICAL MARKER; DNA; HYDROCORTISONE; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; NEUROHORMONE; NEUROTRANSMITTER; NORADRENALIN; OXYTOCIN; PRASTERONE;

BRAIN CIRCULATION; BRAIN LEVEL; BREAST CANCER; CANCER GROWTH; CANCER PATIENT; CARCINOGENESIS; CELL LEVEL; CHOLINERGIC SYSTEM; CHRONIC STRESS; CIRCADIAN RHYTHM; DEPRESSION; DNA DAMAGE; HEART RATE VARIABILITY; HOPELESSNESS; HUMAN; HYDROCORTISONE BLOOD LEVEL; INFLAMMATION; LONELINESS; LONGITUDINAL STUDY; MEDIATOR; MENTAL STRESS; METASTASIS INHIBITION; METASTASIS POTENTIAL; NEOPLASM; NONHUMAN; NORADRENALIN BRAIN LEVEL; PRIORITY JOURNAL; PROGNOSIS; PSYCHOPHYSIOLOGY; REVIEW; SCORING SYSTEM; SOCIAL PSYCHOLOGY; SOCIAL SUPPORT; TISSUE LEVEL; TUMOR IMMUNITY; VAGUS NERVE; ANIMAL; ANXIETY; HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS SYSTEM; METABOLISM; PSYCHOLOGICAL ASPECT;

ANIMALS; ANXIETY; DEHYDROEPIANDROSTERONE; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; NEOPLASMS; PITUITARY-ADRENAL SYSTEM; STRESS, PSYCHOLOGICAL;

EID: 47249159532     PISSN: 10408746     EISSN: None     Source Type: Journal    
DOI: 10.1097/CCO.0b013e3282fbcd0d     Document Type: Review

References (86)

1. McKenna MC, Zevon MA, Corn B, Rounds J. Psychosocial factors and the development of breast cancer: a meta-analysis. Health Psychol 1999; 18: 520-531.
2. Nielsen NR, Grønbaek M. Stress and breast cancer: a systematic update on the current knowledge. Nat Clin Pract Oncol 2006; 3:612-620.
3. Coyne JC, Stefanek M, Palmer SC. Psychotherapy and survival in cancer: the conflict between hope and evidence. Psychol Bull 2007; 133:367-394. Critically reviews psychological randomized controlled trials on survival in cancer.
4. Taylor S. Health psychology. 3rd ed. New York: McGraw-Hill; 1995.
5. Lazarus RS, Folkman S. Stress, appraisal, and coping. New York: Springer; 1984.
6. Speisman JC, Lazarus RS, Mordkoff AM, Davison LA. Experimental analysis of a film used as a threatening stimulus. J Consulting Psychol 1964; 28:23-33.
7. Knudson AG. Mutation and cancer: Statistical study of retinoblastoma. Proc Natl Acad Sci U S A 1971; 68:820-823.
8. Knudson AG. Hereditary cancer: two hits revisited. J Cancer Res Clin Oncol 1996; 122:135-140.
9. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000; 100:57-70.
10. Pawelec G. Tumour escape: antitumour effectors too much of a good thing? Cancer Immunol Immunother 2004; 53:262-274.
11. Voronov E, Shouval DS, Krelin Y, et al. IL-1 is required for tumor invasiveness and angiogenesis. Proc Natl Acad Sci U S A 2003; 100:2645-2650.
12. Tlsty TD, Coussens LM. Tumor stroma and regulation of cancer development. Annu Rev Pathol 2006; 1:119-150.
13. Garssen B. Psychological factors and cancer development: evidence after 30 years of research. Clin Psychol Rev 2004; 24:315-338.
14. Jensen MR. Psychobiological factors predicting the course of breast cancer. J Person 1987; 55:317-342.
15. Watson M, Homewood J, Haviland J, Bliss JM. Influence of psychological response on breast cancer survival: 10-year follow-up of a population-based cohort. Eur J Cancer 2005; 41:1710-1714.
16. Butow PN, Coates AS, Dunn SM. Psychosocial predictors of survival in metastatic melanoma. J Clin Oncol 1999; 17:2256-2263.
17. Faller H, Bülzebruck H. Coping and survival in lung cancer: a 10-year follow-up. Am J Psychiatry 2002; 159:2105-2107.
18. Sklar LS, Anisman H. Stress and coping factors influence tumor growth. Science 1979; 205:513-515.
19. Palermo-Neto J, de Oliveira Massoco C, Robespierre de Souza W. Effects of physical and psychological stressors on behavior, macrophage activity, and Ehrlich tumor growth. Brain Behav Immun 2003; 17:43-54.
20. Wu W, Yamaura T, Murakami K, et al. Involvement of TNF-alpha in enhancement of invasion and metastasis of colon 26-L5 carcinoma cells in mice by social isolation stress. Oncol Res 1999; 11:461-469.
21. Wu W, Murata J, Murakami K, et al. Social isolation stress augments angiogenesis induced by colon 26-L5 carcinoma cells in mice. Clin Exp Metastasis 2000; 18:1-10.
22. Stratakis CA, Chrousos GP. Neuroendocrinology and pathophysiology of the stress system. Ann N Y Acad Sci 1995; 771:1-18.
23. Gold PW, Drevets WC, Charney DS. New insights into the role of cortisol and the glucocorticoid receptor in severe depression. Biol Psychiatry 2002; 52:381-385.
24. Charney DS. Psychobiological mechanisms of resilience and vulnerability: implications for successful adaptation to extreme stress. Am J Psychiatry 2004; 161:195-216.
25. Karlamangla AS, Singer BH, McEwen BS, et al. Allostatic load as a predictor of functional decline: MacArthur studies of successful aging. J Clin Epidemiol 2002; 55:696-710.
26. McEwen BS. Stress, adaptation, and disease. Allostasis and allostatic load. Ann N Y Acad Sci 1998; 840:33-44.
27. Seeman TE, Singer BH, Rowe JW, et al. Price of adaptation - allostatic load and its health consequences: MacArthur studies of successful aging. Arch Intern Med 1997; 157:2259-2268.
28. Seeman TE, McEwen BS, Rowe JW, Singer BH. Allostatic load as a marker of cumulative biological risk: MacArthur studies of successful aging. Proc Natl Acad Sci USA 2001; 98:4470-4475.
29. Ronson A. Psychological stress in oncology: the role of glucocorticoids. Bull Cancer 2006; 93:699-708.
30. Sephton SE, Sapolsky RM, Kraemer HC, Spiegel D. Diurnal cortisol rhythm as a predictor of breast cancer survival. J Natl Cancer Inst 2000; 92:994-1000.
31. Danev S, Svetoslav S, Datzov E. A chronic decrease of heartrate variability can precede some cases of cancer. 3rd World Congress on Cancer, Darwin, Australia; 1997.
32. Antoni MH, Lutgendorf SK, Cole SW, et al. The influence of bio-behavioural factors on tumour biology: pathways and mechanisms. Nat Rev Cancer 2006; 6:240-248.
33. Argaman M, Gidron Y, Ariad S. Interleukin-1 may link helplessness- hopelessness with cancer progression: a proposed model. Int J Behav Med 2005; 12:161-170.
34. Petty F, Chae Y, Kramer G, et al. Learned helplessness sensitizes hippo-campal norepinephrine to mild restress. Biol Psychiatry 1994; 35:903-908.
35. Steptoe A, Owen N, Kunz-Ebrecht SR, Brydon L. Loneliness and neuroendocrine, cardiovascular, and inflammatory stress responses in middle-aged men and women. Psychoneuroendocrinology 2004; 29:593-611.
36. Wong ML, Kling MA, Munson PJ, et al. Pronounced and sustained central hypernoradrenergic function in major depression with melancholic features: relation to hypercortisolism and corticotropin-releasing hormone. Proc Natl Acad Sci U S A 2000; 97:325-330.
37. Soler-Vila H, Kasl SV, Jones BA. Prognostic significance of psychosocial factors in African-American and white breast cancer patients: a population-based study. Cancer 2003; 98:1299-1308.
38. Petty F, Kramer G, Wilson L, Chae YL. Learned helplessness and in vivo hippocampal norepinephrine release. Pharmacol Biochem Behav 1993; 46: 231-235.
39. Sood AK, Bhatty R, Kamat AA, et al. Stress hormone-mediated invasion of ovarian cancer cells. Clin Cancer Res 2006; 12:369-375.
40. Palm D, Lang K, Niggemann B, et al. The norepinephrine-driven metastasis development of PC-3 human prostate cancer cells in BALB/c nude mice is inhibited by beta-blockers. Int J Cancer 2006; 118:2744-2749.
41. Yang EV, Sood AK, Chen M, et al. Norepinephrine up-regulates the expression of vascular endothelial growth factor, matrix metalloproteinase (MMP)-2, and MMP-9 in nasopharyngeal carcinoma tumor cells. Cancer Res 2006; 66:10357-10364.
42. Entschladen F, Drell TL 4th, Lang K, et al. Tumour-cell migration, invasion, and metastasis: navigation by neurotransmitters. Lancet Oncol 2004; 5:254-258.
43. Craddock CG. Corticosteroid-induced lymphopenia, immunosuppression, and body defense. Ann Intern Med 1978; 88:564-566.
44. Wallace ME, Smyth MJ. The role of natural killer cells in tumor control - effectors and regulators of adaptive immunity. Springer Semin Immunopathol 2005; 27:49-64.
45. Ben-Eliyahu S, Yirmiya R, Liebeskind JC, et al. Stress increases metastatic spread of a mammary tumor in rats: evidence for mediation by the immune system. Brain Behav Immun 1991; 5:193-205.
46. Shakhar G, Ben-Eliyahu S. In vivo beta-adrenergic stimulation suppresses natural killer activity and compromises resistance to tumor metastasis in rats. J Immunol 1998; 160:3251-3258.
47. Osborne RH, Sali A, Aaronson NK, et al. Immune function and adjustment style: do they predict survival in breast cancer? Psychooncology 2004; 13:199-210.
48. Ek M, Kurosawa M, Lundeberg T, Ericsson A. Activation of vagal afferents after intravenous injection of interleukin-1beta: role of endogenous prostaglandins. J Neurosci 1998; 18:9471-9479.
49. Tracey KJ. The inflammatory reflex. Nature 2002; 420:853-859.
50. Gidron Y, Perry H, Glennie M. Does the vagus nerve inform the brain about preclinical tumours and modulate them? Lancet Oncol 2005; 6: 245-248. Acknowledgement This article is dedicated to the memory of our dear colleague and friend Dr Miriam Argaman, who died recently, due to our professional ignorance. 392 Supportive care
51. Bernstein IL. Neutral mediation of food aversions and anorexia induced by tumor necrosis factor and tumors. Neurosci Biobehav Rev 1996; 20:177-181.
52. Bernik TR, Friedman SG, Ochani M, et al. Cholinergic antiinflammatory pathway inhibition of tumor necrosis factor during ischemia reperfusion. J Vasc Surg 2002; 36:1231-1236.
53. Mravec B, Gidron Y, Kukanova B, et al. Neural-endocrine-immune complex in the central modulation of tumorigenesis: facts, assumptions, and hypotheses. J Neuroimmunol 2006; 180:104-116.
54. Agelink MW, Boz C, Ullrich H, Andrich J. Relationship between major depression and heart rate variability. Clinical consequences and implications for antidepressive treatment. Psychiatry Res 2002; 113:139-149.
55. Watson M, Haviland JS, Greer S, et al. Influence of psychological response on survival in breast cancer: a population-based cohort study. Lancet 1999; 354:1331-1336.
56. Sackeim HA, Rush AJ, George MS, et al. Vagus nerve stimulation (VNS) for treatment-resistant depression: efficacy, side effects, and predictors of outcome. Neuropsychopharmacology 2001; 25:713-728.
57. Reichenberg A, Yirmiya R, Schuld A, et al. Cytokine- associated emotional and cognitive disturbances in humans. Arch Gen Psychiatry 2001; 58:445-452.
58. Raison CL, Capuron L, Miller AH. Cytokines sing the blues: inflammation and the pathogenesis of depression. Trends Immunol 2006; 27:24-31.
59. Adachi S, Kawamura K, Takemoto K. Oxidative damage of nuclear DNA in liver of rats exposed to psychological stress. Cancer Res 1993; 53:4153-4155.
60. Irie M, Asami S, Nagata S, et al. Classical conditioning of oxidative DNA damage in rats. Neurosci Lett 2000; 288:13-16.
61. Dimitroglou E, Zafiropoulou M, Messini-Nikolaki N, et al. DNA damage in a human population affected by chronic psychogenic stress. Int J Hyg Environ Health 2003; 206:39-44.
62. Irie M, Asami S, Nagata S, et al. Relationships between perceived workload, stress and oxidative DNA damage. Int Arch Occup Environ Health 2001; 74:153-157.
63. Irie M, Asami S, Ikeda M, Kasai H. Depressive state relates to female oxidative DNA damage via neutrophil activation. Biochem Biophys Res Commun 2003; 311:1014-1018.
64. Gidron Y, Russ K, Tissarchondou H, Warner J. The relation between psychological factors and DNA damage: a critical review. Biol Psychol 2006; 72:291-304.
65. Meshorer E, Bryk B, Soreq H, Glucocorticoid-mediated neuronal DNA damage and repair following repeated psychological stress. J Neurochem 2001; 78:167.
66. Gümüşlü S, Sarikçioǧlu SB, Sahin E, et al. Influences of different stress models on the antioxidant status and lipid peroxidation in rat erythrocytes. Free Radic Res 2002; 36:1277-1282.
67. Matsumoto K, Satoh Y, Sugo H, et al. Immunohistochemical study of the relationship between 8-hydroxy-20-deoxyguanosine levels in noncancerous region and postoperative recurrence of hepatocellular carcinoma in remnant liver. Hepatol Res 2003; 25:435-441.
68. Gidron Y, Berger R, Lugasi B, Ilia R. Interactive effects of family history with psychological factors in relation to CAD. Coronary Artery Dis 2002; 13:205-208.
69. Pikarsky E, Porat RM, Stein I, et al. NF-kappaB functions as a tumour promoter in inflammation- associated cancer. Nature 2004; 431:461-466.
70. Kiecolt-Glaser JK, Stephens RE, Lipetz PD, et al. Distress and DNA repair in human lymphocytes. J Behav Med 1985; 8:311-320.
71. Flint MS, Baum A, Chambers WH, Jenkins FJ. Induction of DNA damage, alteration of DNA repair and transcriptional activation by stress hormones. Psychoneuroendocrinology 2007; 32:470-479. Demonstrates effects of stress hormones (e.g., cortisol, norepinephrine) on DNA integrity and repair.
72. Sengupta S, Vonesch JL, Waltzinger C, et al. Negative cross-talk between p53 and the glucocorticoid receptor and its role in neuroblastoma cells. EMBO J 2000; 19:6051-6064.
73. Abramson LY, Metalsky GI, Alloy LB. Hopelessness depression: a theory-based subtype of depression. Psychol Rev 1989; 96:358-372.
74. Maier SF, Watkins LR. Intracerebroventricular interleukin-1 receptor antagonist blocks the enhancement of fear conditioning and interference with escape produced by inescapable shock. Brain Res 1995; 695: 279-282.
75. Hodgson DM, Yirmiya R, Chiappelli F, Taylor AN. Intracerebral interleukin-1beta impairs response to tumor invasion: involvement of adrenal catecholamines. Brain Res 1999; 816:200-208.
76. Nguyen KT, Deak T, Will MJ, et al. Timecourse and corticosterone sensitivity of the brain, pituitary, and serum interleukin-1beta protein response to acute stress. Brain Res 2000; 859:193-201.
77. Arlt A, Vorndamm J, Müerköster S, et al. Autocrine production of interleukin 1beta confers constitutive nuclear factor kappaB activity and chemoresistance in pancreatic carcinoma cell lines. Cancer Res 2002; 62:910-916.
78. Torisu H, Ono M, Kiryu H, et al. Macrophage infiltration correlates with tumor stage and angiogenesis in human malignant melanoma: possible involvement of TNFalpha and IL-1alpha. Int J Cancer 2000; 85:182-188.
79. Garofalo A, Chirivi RG, Foglieni C, et al. Involvement of the very late antigen 4 integrin on melanoma in interleukin 1-augmented experimental metastases. Cancer Res 1995; 55:414-419.
80. Bremmer MA, Deeg DJ, Beekman AT, et al. Major depression in late life is associated with both hypo- and hypercortisolemia. Biol Psychiatry 2007; 62:479-486.
81. Croes S, Merz P, Netter P. Cortisol reaction in success and failure condition in endogenous depressed patients and controls. Psychoneuroendocrinology 1993; 18:23-35.
82. Carter CS, Pournajafi-Nazarloo H, Kramer KM, et al. Oxytocin: behavioral associations and potential as a salivary biomarker. Ann N Y Acad Sci 2007; 1098:312-322. Reviews the social significance of oxytocin and a new method for measuring it sensitively in saliva, thus enabling noninvasive tests in research.
83. Heinrichs M, Baumgartner T, Kirschbaum C, Ehlert U. Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress. Biol Psychiatry 2003; 54:1389-1398.
84. Grewen KM, Girdler SS, Amico J, Light KC. Effects of partner support on resting oxytocin, cortisol, norepinephrine, and blood pressure before and after warm partner contact. Psychosom Med 2005; 67:531-538.
85. Cassoni P, Marrocco T, Deaglio S, et al. Biological relevance of oxytocin and oxytocin receptors in cancer cells and primary tumors. Ann Oncol 2001; 12 (Suppl 2):S37-S39.
86. Kosfeld M, Heinrichs M, Zak PJ, et al. Oxytocin increases trust in humans. Nature 2005; 435:673-676.