Repression of motility during fimbrial expression: Identification of 14 mrpJ gene paralogues in Proteus mirabilis

Molecular Microbiology

Volumn 69, Issue 2, 2008, Pages 548-558

  Pearson, Melanie M ^a   Mobley, Harry L T ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID SEQUENCE; ARTICLE; BACTERIAL GENE; CONTROLLED STUDY; FIMBRIA; GENE EXPRESSION; GENE IDENTIFICATION; GENE OVEREXPRESSION; MRPJ GENE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEUS MIRABILIS; SITE DIRECTED MUTAGENESIS;

BACTERIAL ADHESION; BACTERIAL PROTEINS; CONSERVED SEQUENCE; DNA, BACTERIAL; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FIMBRIAE, BACTERIAL; FLAGELLIN; GENES, BACTERIAL; HELIX-TURN-HELIX MOTIFS; LOCOMOTION; MICROSCOPY, ELECTRON, TRANSMISSION; MUTAGENESIS, INSERTIONAL; MUTAGENESIS, SITE-DIRECTED; OPERON; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; PROTEUS MIRABILIS; REPRESSOR PROTEINS; SEQUENCE ANALYSIS, DNA; SEQUENCE HOMOLOGY, AMINO ACID;

PROTEUS MIRABILIS;

EID: 47249136979     PISSN: 0950382X     EISSN: 13652958     Source Type: Journal    
DOI: 10.1111/j.1365-2958.2008.06307.x     Document Type: Article

References (33)

1. Adegbola, R.A., Old, D.C. Senior, B.W. (1983) The adhesins and fimbriae of Proteus mirabilis strains associated with high and low affinity for the urinary tract. J Med Microbiol 16 : 427 431.
2. Akerley, B.J., Cotter, P.A. Miller, J.F. (1995) Ectopic expression of the flagellar regulon alters development of the Bordetella-host interaction. Cell 80 : 611 620.
3. Bahrani, F.K. Mobley, H.L. (1993) Proteus mirabilis MR/P fimbriae: molecular cloning, expression, and nucleotide sequence of the major fimbrial subunit gene. J Bacteriol 175 : 457 464.
4. Bahrani, F.K., Johnson, D.E., Robbins, D. Mobley, H.L. (1991) Proteus mirabilis flagella and MR/P fimbriae: isolation, purification, N-terminal analysis, and serum antibody response following experimental urinary tract infection. Infect Immun 59 : 3574 3580.
5. Bahrani, F.K., Cook, S., Hull, R.A., Massad, G. Mobley, H.L. (1993) Proteus mirabilis fimbriae: N-terminal amino acid sequence of a major fimbrial subunit and nucleotide sequences of the genes from two strains. Infect Immun 61 : 884 891.
6. Bahrani, F.K., Massad, G., Lockatell, C.V., Johnson, D.E., Russell, R.G., Warren, J.W. Mobley, H.L. (1994) Construction of an MR/P fimbrial mutant of Proteus mirabilis: role in virulence in a mouse model of ascending urinary tract infection. Infect Immun 62 : 3363 3371.
7. Bijlsma, I.G., van Dijk, L., Kusters, J.G. Gaastra, W. (1995) Nucleotide sequences of two fimbrial major subunit genes, pmpA and ucaA, from canine-uropathogenic Proteus mirabilis strains. Microbiology 141 (Part 6 1349 1357.
8. Bryan, A., Roesch, P., Davis, L., Moritz, R., Pellett, S. Welch, R.A. (2006) Regulation of type 1 fimbriae by unlinked FimB- and FimE-like recombinases in uropathogenic Escherichia coli strain CFT073. Infect Immun 74 : 1072 1083.
9. Clegg, S. Hughes, K.T. (2002) FimZ is a molecular link between sticking and swimming in Salmonella enterica serovar Typhimurium. J Bacteriol 184 : 1209 1213.
10. Coker, C., Poore, C.A., Li, X. Mobley, H.L. (2000) Pathogenesis of Proteus mirabilis urinary tract infection. Microbes Infect 2 : 1497 1505.
11. Cook, S.W., Mody, N., Valle, J. Hull, R. (1995) Molecular cloning of Proteus mirabilis uroepithelial cell adherence (uca) genes. Infect Immun 63 : 2082 2086.
12. Finlay, B.B. Falkow, S. (1997) Common themes in microbial pathogenicity revisited. Microbiol Mol Biol Rev 61 : 136 169.
13. Gardel, C.L. Mekalanos, J.J. (1996) Alterations in Vibrio cholerae motility phenotypes correlate with changes in virulence factor expression. Infect Immun 64 : 2246 2255.
14. He, H., Snyder, H.A. Forst, S. (2004) Unique organization and regulation of the mrx fimbrial operon in Xenorhabdus nematophila. Microbiology 150 : 1439 1446.
15. Heimer, S.R. Mobley, H.L. (2001) Interaction of Proteus mirabilis urease apoenzyme and accessory proteins identified with yeast two-hybrid technology. J Bacteriol 183 : 1423 1433.
16. Jansen, A.M., Lockatell, C.V., Johnson, D.E. Mobley, H.L. (2003) Visualization of Proteus mirabilis morphotypes in the urinary tract: the elongated swarmer cell is rarely observed in ascending urinary tract infection. Infect Immun 71 : 3607 3613.
17. Lane, M.C., Simms, A.N. Mobley, H.L. (2007) Complex interplay between type 1 fimbrial expression and flagellum-mediated motility of uropathogenic Escherichia coli. J Bacteriol 189 : 5523 5533.
18. Latta, R.K., Grondin, A., Jarrell, H.C., Nicholls, G.R. Bérubé, L.R. (1999) Differential expression of nonagglutinating fimbriae and MR/P pili in swarming colonies of Proteus mirabilis. J Bacteriol 181 : 3220 3225.
19. Li, X., Rasko, D.A., Lockatell, C.V., Johnson, D.E. Mobley, H.L. (2001) Repression of bacterial motility by a novel fimbrial gene product. EMBO J 20 : 4854 4862.
20. Li, X., Lockatell, C.V., Johnson, D.E. Mobley, H.L. (2002) Identification of MrpI as the sole recombinase that regulates the phase variation of MR/P fimbria, a bladder colonization factor of uropathogenic Proteus mirabilis. Mol Microbiol 45 : 865 874.
21. Livak, K.J. Schmittgen, T.D. (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25 : 402.
22. Macnab, R.M. (1996) Flagella and motility. In Escherichia coli and Salmonella: Cellular and Molecular Biology. Neidhardt, F.C. (ed.). Washington, DC : American Society for Microbiology Press, pp. 123 145.
23. Massad, G., Lockatell, C.V., Johnson, D.E. Mobley, H.L. (1994a) Proteus mirabilis fimbriae: construction of an isogenic pmfA mutant and analysis of virulence in a CBA mouse model of ascending urinary tract infection. Infect Immun 62 : 536 542.
24. Massad, G., Bahrani, F.K. Mobley, H.L. (1994b) Proteus mirabilis fimbriae: identification, isolation, and characterization of a new ambient-temperature fimbria. Infect Immun 62 : 1989 1994.
25. Meslet-Cladiere, L.M., Pimenta, A., Duchaud, E., Holland, I.B. Blight, M.A. (2004) In vivo expression of the mannose-resistant fimbriae of Photorhabdus temperata K122 during insect infection. J Bacteriol 186 : 611 622.
26. Mobley, H.L. Warren, J.W. (1987) Urease-positive bacteriuria and obstruction of long-term urinary catheters. J Clin Microbiol 25 : 2216 2217.
27. Mobley, H.L., Belas, R., Lockatell, V., Chippendale, G., Trifillis, A.L., Johnson, D.E. Warren, J.W. (1996) Construction of a flagellum-negative mutant of Proteus mirabilis: effect on internalization by human renal epithelial cells and virulence in a mouse model of ascending urinary tract infection. Infect Immun 64 : 5332 5340.
28. Pearson, M.M., Sebaihia, M., Churcher, C., Quail, M.A., Seshasayee, A.S., Luscombe, N.M., et al. (2008) The complete genome sequence of uropathogenic Proteus mirabilis, a master of both adherence and motility. J Bacteriol 190 : 4027 4037.
29. Rather, P.N. (2005) Swarmer cell differentiation in Proteus mirabilis. Environ Microbiol 7 : 1065 1073.
30. Simm, R., Morr, M., Kader, A., Nimtz, M. Römling, U. (2004) GGDEF and EAL domains inversely regulate cyclic di-GMP levels and transition from sessility to motility. Mol Microbiol 53 : 1123 1134.
31. Tolson, D.L., Barrigar, D.L., McLean, R.J. Altman, E. (1995) Expression of a nonagglutinating fimbria by Proteus mirabilis. Infect Immun 63 : 1127 1129.
32. Wray, S.K., Hull, S.I., Cook, R.G., Barrish, J. Hull, R.A. (1986) Identification and characterization of a uroepithelial cell adhesin from a uropathogenic isolate of Proteus mirabilis. Infect Immun 54 : 43 49.
33. Zhao, H., Li, X., Johnson, D.E., Blomfield, I. Mobley, H.L. (1997) In vivo phase variation of MR/P fimbrial gene expression in Proteus mirabilis infecting the urinary tract. Mol Microbiol 23 : 1009 1019.