Activation of cytosolic phospholipase A2 and fatty acid transacylase is essential but not sufficient for thrombin-induced smooth muscle cell proliferation

American Journal of Physiology - Cell Physiology

Volumn 294, Issue 6, 2008, Pages

  Gluck, Nathan ^a   Schwob, Ouri ^a   Krimsky, Miron ^a   Yedgar, Saul ^a,b  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Lysophosphatidic acid acyltransferase; Protease activated receptor 1

Indexed keywords

ACYL[ACYL CARRIER PROTEIN] PHOSPHOLIPID ACYLTRANSFERASE; ACYLTRANSFERASE; ARACHIDONIC ACID; ARACHIDONYL TRIFLUOROMETHYLKETONE; COMPLEMENTARY DNA; FATTY ACID; LYSOPHOSPHATIDIC ACID; MESSENGER RNA; OLEIC ACID; PHOSPHOLIPASE A2; PHOSPHOLIPASE A2 INHIBITOR; PROTEINASE ACTIVATED RECEPTOR 1; RNA 28S; TRITIUM; UNCLASSIFIED DRUG; 2 ACYLGLYCEROPHOSPHATE ACYLTRANSFERASE; 2-ACYLGLYCEROPHOSPHATE ACYLTRANSFERASE; ARACHIDONIC ACID DERIVATIVE; ARACHIDONYLTRIFLUOROMETHANE; ENZYME INHIBITOR; N3 CYCLOPROPYL 7 ((4 (1 METHYLETHYL)PHENYL)METHYL) 7H PYRROLO(3, 2 F)QUINAZOLINE 1,3 DIAMINE; N3-CYCLOPROPYL-7-((4-(1-METHYLETHYL)PHENYL)METHYL)-7H-PYRROLO(3, 2-F)QUINAZOLINE-1,3-DIAMINE; PHOSPHOLIPASE A2 GROUP IV; PHOSPHOLIPID; PYRROLE DERIVATIVE; QUINAZOLINE DERIVATIVE; THIOMERSAL; THROMBIN;

ANIMAL CELL; AORTA; ARACHIDONIC ACID METABOLISM; ARTICLE; ATHEROSCLEROSIS; CATTLE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ISOTOPE LABELING; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; VASCULAR SMOOTH MUSCLE; WESTERN BLOTTING; ANIMAL; CELL CULTURE; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENETICS; HUMAN; METABOLISM; SMOOTH MUSCLE FIBER; TIME;

BOVINAE;

ACYLTRANSFERASES; ANIMALS; ARACHIDONIC ACID; ARACHIDONIC ACIDS; CATTLE; CELL PROLIFERATION; CELLS, CULTURED; ENZYME INHIBITORS; FATTY ACIDS; GROUP IV PHOSPHOLIPASES A2; HUMANS; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PHOSPHOLIPIDS; PYRROLES; QUINAZOLINES; RECEPTOR, PAR-1; RNA, MESSENGER; THIMEROSAL; THROMBIN; TIME FACTORS;

EID: 47249135717     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00206.2007     Document Type: Article

References (28)

1. Ahn HS, Foster C, Boykow G, Stamford A, Manna M, Graziano M. Inhibition of cellular action of thrombin by N3-cyclopropyl-7-{[4-(1- methylethyl)phenyl]methyl}-7H-pyrrolo[3, 2-f]quinazoline-1,3-diamine (SCH 79797), a nonpeptide thrombin receptor antagonist. Biochem Pharmacol 60: 1425-1434, 2000.
2. Anderson KM, Roshak A, Winkler JD, McCord M, Marshall LA. Cytosolic 85-kDa phospholipase A2-mediated release of arachidonic acid is critical for proliferation of vascular smooth muscle cells. J Biol Chem 272: 30504-30511, 1997.
3. Andrade-Gordon P, Maryanoff BE, Derian CK, Zhang HC, Addo MF, Darrow AL, Eckardt AJ, Hoekstra WJ, McComsey DF, Oksenberg D, Reynolds EE, Santulli RJ, Scarborough RM, Smith CE, White KB. Design, synthesis, and biological characterization of a peptide-mimetic antagonist for a tethered-ligand receptor. Proc Natl Acad Sci USA 96: 12257-12262, 1999.
4. Asai K, Hirabayashi T, Houjou T, Uozumi N, Taguchi R, Shimizu T. Human group IVC phospholipase A2 (cPLA2gamma). Roles in the membrane remodeling and activation induced by oxidative stress. J Biol Chem 278: 8809-8814, 2003.
5. 2+- independent PLA2. Am J Physiol Cell Physiol 290: C1350-C1354, 2006.
6. Bretschneider E, Kaufmann R, Braun M, Nowak G, Glusa E, Schror K. Evidence for functionally active protease-activated receptor-4 (PAR-4) in human vascular smooth muscle cells. Br J Pharmacol 132: 1441-1446, 2001.
7. Bretschneider E, Spanbroek R, Lotzer K, Habenicht AJ, Schror K. Evidence for functionally active protease-activated receptor-3 (PAR-3) in human vascular smooth muscle cells. Thromb Haemost 90: 704-709, 2003.
8. Bydlowski SP, Pares MM, Soares RP, Lopes AA. Stimulation of human smooth muscle cell proliferation by thrombin involves increased synthesis of platelet-derived growth factor. Chest 114: 236-240, 1998.
9. Chai YC, Binion DG, Chisolm GM. Relationship of molecular structure to the mechanism of lysophospholipid-induced smooth muscle cell proliferation. Am J Physiol Heart Circ Physiol 279: H1830-H1838, 2000.
10. 2+ influx, enhanced DNA synthesis and cytotoxicity in cultured vascular smooth muscle cells. Atherosclerosis 112: 69-76, 1995.
11. 2. Prostaglandins Leukot Essent Fatty Acids 69: 87-97, 2003.
12. Ghosh M, Tucker DE, Burchett SA, Leslie CC. Properties of the group IV phospholipase A2 family. Prog Lipid Res 45: 487-510, 2006.
13. Irons CE, Flynn MA, Mok LM, Reynolds EE. Endothelin and PDGF enhance arachidonic acid release and DNA synthesis in vascular smooth muscle cells. Am J Physiol Cell Physiol 270: C1642-C1646, 1996.
14. Koo BH, Chung KH, Hwang KC, Kim DS. Factor Xa induces mitogenesis of coronary artery smooth muscle cell via activation of PAR-2. FEBS Lett 523: 85-89, 2002.
15. 2+-independent phospholipase A2. Biochim Biophys Acta 1391: 384-400, 1998.
16. Mistry DH, Medrano JF. Cloning and localization of the bovine and ovine lysophosphatidic acid acyltransferase (LPAAT) genes that codes for an enzyme involved in triglyceride biosynthesis. J Dairy Sci 85: 28-35, 2002.
17. Monjazeb AM, High KP, Koumenis C, Chilton FH. Inhibitors of arachidonic acid metabolism act synergistically to signal apoptosis in neoplastic cells. Prostaglandins Leukot Essent Fatty Acids 73: 463-474, 2005.
18. Nishio E, Watanabe Y. The involvement of reactive oxygen species and arachidonic acid in alpha 1-adrenoceptor-induced smooth muscle cell proliferation and migration. Br J Pharmacol 121: 665-670, 1997.
19. Perez R, Matabosch X, Llebaria A, Balboa MA, Balsinde J. Blockade of arachidonic acid incorporation into phospholipids induces apoptosis in U937 promonocytic cells. J Lipid Res 47: 484-491, 2006.
20. Reisfeld N, Lichtenberg D, Dagan A, Yedgar S. Apolipoprotein B exhibits phospholipase A1 and phospholipase A2 activities. FEBS Lett 315: 267-270, 1993.
21. 2+-independent phospholipase A2 in cell growth and maintenance of phospholipids. J Pharmacol Exp Ther 318: 1211-1219, 2006.
22. Schwartz SM, Campbell GR, Campbell JH. Replication of smooth muscle cells in vascular disease. Circ Res 58: 427-444, 1986.
23. 2. Thorax 60: 747-753, 2005.
24. Traynelis SF, Trejo J. Protease-activated receptor signaling: new roles and regulatory mechanisms. Curr Opin Hematol 14: 230-235, 2007.
25. Triggiani M, Granata F, Frattini A, Marone G. Activation of human inflammatory cells by secreted phospholipases A2. Biochim Biophys Acta 1761: 1289-1300, 2006.
26. Yamashita A, Kamata R, Kawagishi N, Nakanishi H, Suzuki H, Sugiura T, Waku K. Roles of C-terminal processing, and involvement in transacylation reaction of human group IVC phospholipase A2 (cPLA2gamma). J Biochem (Tokyo) 137: 557-567, 2005.
27. Yellaturu CR, Rao GN. A requirement for calcium-independent phospholipase A2 in thrombin-induced arachidonic acid release and growth in vascular smooth muscle cells. J Biol Chem 278: 43831-43837, 2003.
28. Zarini S, Gijon MA, Folco G, Murphy RC. Effect of arachidonic acid reacylation on leukotriene biosynthesis in human neutrophils stimulated with granulocyte-macrophage colony-stimulating factor and formyl-methionylleucyl- phenylalanine. J Biol Chem 281: 10134-10142, 2006.