Phosphorylation of delta2 glutamate receptors at serine 945 is not required for cerebellar long-term depression

Keio Journal of Medicine

Volumn 57, Issue 2, 2008, Pages 105-110

  Nakagami, Ryoichi ^a,b   Kohda, Kazuhisa ^a   Kakegawa, Wataru ^a   Kondo, Tetsuro ^a   Kato, Nobumasa ^b   Yuzaki, Michisuke ^a  

^a KEIO UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

2 glutamate receptor; Cerebellum; Long term depression; Phosphorylation; Purkinje cell

Indexed keywords

ALANINE; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR DELTA 2; PROTEIN KINASE C; SERINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CEREBELLUM; CONTROLLED STUDY; GENE; GLUTAMATE RECEPTOR DELTA 2 GENE; LONG TERM DEPRESSION; MOUSE; NERVE CELL; NERVE CELL PLASTICITY; NONHUMAN; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PURKINJE CELL; SYNAPSE;

ANIMALS; CEREBELLUM; ELECTROPHYSIOLOGY; LONG-TERM SYNAPTIC DEPRESSION; MICE; MICE, KNOCKOUT; PATCH-CLAMP TECHNIQUES; PHOSPHORYLATION; PHOSPHOSERINE; PURKINJE CELLS; RECEPTORS, GLUTAMATE;

EID: 47249132139     PISSN: 00229717     EISSN: 18801293     Source Type: Journal    
DOI: 10.2302/kjm.57.105     Document Type: Article

References (27)

1. Ito M: Long-term depression. Annu Rev Neurosci 1989;12:85-102
2. Matsuda S, Launey T, Mikawa S, Hirai H: Disruption of AMPA receptor GluR2 clusters following long-term depression induction in cerebellar Purkinje neurons. EMBO J 2000;19:2765-2774
3. Wang YT, Linden DJ: Expression of cerebellar long-term depression requires postsynaptic clathrin-mediated endocytosis. Neuron 2000;25:635-647
4. Yuzaki M: The delta2 glutamate receptor: 10 years later. Neurosci Res 2003;46:11-22
5. Kashiwabuchi N, Ikeda K, Araki K, Hirano T, Shibuki K, Takayama C, Inoue Y, Kutsuwada T, Yagi T, Kang Y, Aizawa S, Mishina M: Impairment of motor coordination, Purkinje cell synapse formation, and cerebellar long-term depression in GluRδ2 mutant mice. Cell 1995;81:245-252
6. Motohashi J, Kakegawa W, Yuzaki M: Ho15J: a new hotfoot allele in a hot spot in the gene encoding the delta2 glutamate receptor. Brain Res 2007;1140:153-160
7. Hirai H, Launey T, Mikawa S, Torashima T, Yanagihara D, Kasaura T, Miyamoto A, Yuzaki M: New role of δ2 glutamate receptors in AMPA receptor trafficking and cerebellar function. Nat Neurosci 2003;6:869-876
8. 2+ permeability of the channel pore is not essential for the δ2 glutamate receptor to regulate synaptic plasticity and motor coordination. J Physiol 2007;579:729-735
9. Kakegawa W, Kohda K, Yuzaki M: The delta2 'ionotropic' glutamate receptor functions as a non-ionotropic receptor to control cerebellar synaptic plasticity. J Physiol 2007;584:89-96
10. Roche KW, Ly CD, Petralia RS, Wang YX, McGee AW, Bredt DS, Wenthold RJ: Postsynaptic density-93 interacts with the δ2 glutamate receptor subunit at parallel fiber synapses. J Neurosci 1999;19:3926-3934
11. Hironaka K, Umemori H, Tezuka T, Mishina M, Yamamoto T: The protein-tyrosine phosphatase PTPMEG interacts with glutamate receptor δ2 and ε subunits. J Biol Chem 2000;275:16167-16173
12. Yap CC, Muto Y, Kishida H, Hashikawa T, Yano R: PKC regulates the δ2 glutamate receptor interaction with S-SCAM/MAGI-2 protein. Biochem Biophys Res Commun 2003;301:1122-1128
13. Miyagi Y, Yamashita T, Fukaya M, Sonoda T, Okuno T, Yamada K, Watanabe M, Nagashima Y, Aoki I, Okuda K, Mishina M, Kawamoto S: Delphilin: a novel PDZ and formin homology domain-containing protein that synaptically colocalizes and interacts with glutamate receptor δ2 subunit. J Neurosci 2002;22:803-814
14. Crepel F, Krupa M: Activation of protein kinase C induces a long-term depression of glutamate sensitivity of cerebellar Purkinje cells. An in vitro study. Brain Res 1988;458:397-401
15. Linden DJ, Connor JA: Participation of postsynaptic PKC in cerebellar long-term depression in culture. Science 1991;254:1656-1659
16. Goossens J, Daniel H, Rancillac A, van der Steen J, Oberdick J, Crepel F, De Zeeuw CI, Frens MA: Expression of protein kinase C inhibitor blocks cerebellar long-term depression without affecting Purkinje cell excitability in alert mice. J Neurosci 2001;21:5813-5823
17. Tsuruno S, Hirano T: Persistent activation of protein kinase Calpha is not necessary for expression of cerebellar long-term depression. Mol Cell Neurosci 2007; 35: 38-48
18. Chung HJ, Steinberg JP, Huganir RL, Linden DJ: Requirement of AMPA receptor GluR2 phosphorylation for cerebellar long-term depression. Science 2003;300:1751-1755
19. Kondo T, Kakegawa W, Yuzaki M: Induction of long-term depression and phosphorylation of the delta2 glutamate receptor by protein kinase C in cerebellar slices. Eur J Neurosci 2005;22:1817-1820
20. Deng F, Price MG, Davis CF, Mori M, Burgess DL: Stargazin and other transmembrane AMPA receptor regulating proteins interact with synaptic scaffolding protein MAGI-2 in brain. J Neurosci 2006;26:7875-7884
21. Nicoll RA, Tomita S, Bredt DS: Auxiliary subunits assist AMPA-type glutamate receptors. Science 2006;311:1253-1256
22. Kohda K, Kakegawa W, Matsuda S, Nakagami R, Kakiya N, Yuzaki M: The extreme C-terminus of GluRδ2 is essential for induction of long-term depression in cerebellar slices. Eur J Neurosci 2007;25:1357-1362
23. Zucker RS, Regehr WG: Short-term synaptic plasticity. Annu Rev Physiol 2002;64:355-405
24. Hirai H, Miyazaki T, Kakegawa W, Matsuda S, Mishina M, Watanabe M, Yuzaki M: Rescue of abnormal phenotypes of the δ2 glutamate receptor-null mice by mutant δ2 transgenes. EMBO Rep 2005;6:90-95
25. Kakegawa W, Miyazaki T, Emi K, Matsuda K, Kohda K, Motohashi J, Mishina M, Kawahara S, Watanabe M, Yuzaki M: Differential regulation of synaptic plasticity and cerebellar motor learning by the C-terminal PDZ-binding motif of GluRdelta2. J Neurosci 2008;28:1460-1468
26. Yuzaki M: The δ2 glutamate receptor: a key molecule controlling synaptic plasticity and structure in Purkinje cells. Cerebellum 2004;3:89-93
27. Dean C, Scholl FG, Choih J, DeMaria S, Berger J, Isacoff E, Scheiffele P: Neurexin mediates the assembly of presynaptic terminals. Nat Neurosci 2003;6:708-716