Induction of suppressor of cytokine signaling-3 in astrocytes of the rat hippocampus following transient forebrain ischemia

Neuroscience Letters

Volumn 441, Issue 3, 2008, Pages 323-327

  Choi, Jeong Sun ^a   Shin, Yoo Jin ^a   Cha, Jung Ho ^a   Kim, Ha Young ^a   Choi, Jae Youn ^a   Chun, Myung Hoon ^a   Lee, Mun Yong ^a  

^a The Catholic University of Korea   (South Korea)

Author keywords

Hippocampus; Reactive astrocytes; SOCS 3; Transient forebrain ischemia

Indexed keywords

MESSENGER RNA; SUPPRESSOR OF CYTOKINE SIGNALING 3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CONTROLLED STUDY; DENTATE GYRUS; FOREBRAIN; GRANULE CELL; HIPPOCAMPUS; IN SITU HYBRIDIZATION; MACROGLIA; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN LOCALIZATION; PYRAMIDAL NERVE CELL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSIENT ISCHEMIC ATTACK;

ANIMALS; ASTROCYTES; BIOLOGICAL MARKERS; CALCIUM-BINDING PROTEINS; DISEASE MODELS, ANIMAL; FLUORESCENT ANTIBODY TECHNIQUE; GLIAL FIBRILLARY ACIDIC PROTEIN; GLIOSIS; HIPPOCAMPUS; HYPOXIA-ISCHEMIA, BRAIN; ISCHEMIC ATTACK, TRANSIENT; MALE; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS;

EID: 47249113372     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2008.06.051     Document Type: Article

References (23)

1. kB activation precedes glial reactivity in the excitotoxically injured young cortex but not in the corresponding distal thalamic nuclei. J. Neuropathol. Exp. Neurol. 59 (2000) 151-163
2. Campbell I.L. Cytokine-mediated inflammation, tumorigenesis, and disease-associated JAK/STAT/SOCS signaling circuits in the CNS. Brain Res. Rev. 48 (2005) 166-177
3. Choi W.H., Ji K.A., Jeon S.B., Yang M.S., Kim H., Min K.J., Shong M., Jou I., and Joe E.H. Anti-inflammatory roles of retinoic acid in rat brain astrocytes: Suppression of interferon-gamma-induced JAK/STAT phosphorylation. Biochem. Biophys. Res. Commun. 329 (2005) 125-131
4. Choi J.S., Kim S.Y., Cha J.H., Choi Y.S., Sung K.W., Oh S.T., Kim O.N., Chung J.W., Chun M.H., Lee S.B., and Lee M.Y. Upregulation of gp130 and STAT3 activation in the rat hippocampus following transient forebrain ischemia. Glia 41 (2003) 237-246
5. Choi J.S., Kim S.Y., Park H.J., Cha J.H., Choi Y.S., Kang J.E., Chung J.W., Chun M.H., and Lee M.Y. Upregulation of gp130 and differential activation of STAT and p42/44 MAPK in the rat hippocampus following kainic acid-induced seizures. Mol. Brain Res. 119 (2003) 10-18
6. Endo T.A., Masuhara M., Yokouchi M., Suzuki R., Sakamoto H., Mitsui K., Matsumoto A., Tanimura S., Ohtsubo M., Misawa H., Miyazaki T., Leonor N., Taniguchi T., Fujita T., Kanakura Y., Komiya S., and Yoshimura A. A new protein containing an SH2 domain that inhibits JAK kinases. Nature 387 (1997) 921-924
7. Jorgensen M.B., Finsen B.R., Jensen M.B., Castellano B., Diemer N.H., and Zimmer J. Microglial and astroglial reactions to ischemic and kainic acid-induced lesions of the adult rat hippocampus. Exp. Neurol. 120 (1993) 70-88
8. Justicia C., Gabriel C., and Planas A.M. Activation of the Jak/Stat pathway following transient focal cerebral ischemia: signalling through Jak1 and Stat3 in astrocytes. Glia 30 (2000) 253-270
9. Lee M.Y., Shin S.L., Choi Y.S., Kim E.J., Cha J.H., Chun M.H., Lee S.B., and Kim S.Y. Transient upregulation of osteopontin mRNA in hippocampus and striatum following global forebrain ischemia in rats. Neurosci. Lett. 271 (1999) 81-84
10. Nicholson S.E., De Souza D., Fabri L.J., Corbin J., Willson T.A., Zhang J.G., Silva A., Asimakis M., Farley A., Nash A.D., Metcalf D., Hilton D.J., Nicola N.A., and Baca M. Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130. Proc. Natl. Acad. Sci. U.S.A. 97 (2000) 6493-6498
11. Okada S., Nakamura M., Katoh H., Miyao T., Shimazaki T., Ishii K., Yamane J., Yoshimura A., Iwamoto Y., Toyama Y., and Okano H. Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury. Nat. Med. 12 (2006) 829-834
12. Park E.J., Park S.Y., Joe E.H., and Jou I. 15d-PGJ2 and rosiglitazone suppress Janus kinase-STAT inflammatory signaling through induction of suppressor of cytokine signaling 1 (SOCS1) and SOCS3 in glia. J. Biol. Chem. 278 (2003) 14747-14752
13. Planas A.M., Soriano M.A., Burruezo M., Justicia C., Estrada A., Pitarch S., and Ferrer I. Induction of Stat3, a signal transducer and transcription factor, in reactive microglia following transient focal cerebral ischemia. Eur. J. Neurosci. 8 (1996) 2612-2618
14. Pulsinelli W.A., and Brierley J.B. A new model of bilateral hemi-spheric ischemia in the unanesthetized rat. Stroke 10 (1979) 267-272
15. Pulsinelli W.A., Brierley J.B., and Plum F. Temporal profile of neuronal damage in a model of transient forebrain ischemia. Ann. Neurol. 11 (1982) 491-498
16. Qin H., Roberts K.L., Niyongere S.A., Cong Y., Elson C.O., and Benveniste E.N. Molecular mechanism of lipopolysaccharide-induced SOCS-3 gene expression in macrophages and microglia. J. Immunol. 179 (2007) 5966-5976
17. Rosell D.R., Akama K.T., Nacher J., and McEwen B.S. Differential expression of suppressors of cytokine signaling-1, -2, and -3 in the rat hippocampus after seizure: implications for neuromodulation by gp130 cytokines. Neuroscience 122 (2003) 349-358
18. Satriotomo I., Bowen K.K., and Vemuganti R. JAK2 and STAT3 activation contributes to neuronal damage following transient focal cerebral ischemia. J. Neurochem. 98 (2006) 1353-1368
19. Schmidt-Kastner R., Szymas J., and Hossmann K.A. Immunohistochemical study of glial reaction and serum-protein extravasation in relation to neuronal damage in rat hippocampus after ischemia. Neuroscience 38 (1990) 527-540
20. Schmitz J., Weissenbach M., Haan S., Heinrich P.C., and Schaper F. SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130. J. Biol. Chem. 275 (2000) 12848-12856
21. Schubert K.O., Naumann T., Schnell O., Zhi Q., Steup A., Hofmann H.D., and Kirsch M. Activation of STAT3 signaling in axotomized neurons and reactive astrocytes after fimbria-fornix transaction. Exp. Brain Res. 165 (2005) 520-531
22. Starr R., and Hilton D.J. Negative regulation of the JAK/STAT pathway. BioEssays 21 (1999) 47-52
23. Suzuki S., Tanaka K., Nogawa S., Dembo T., Kosakai A., and Fukuuchi Y. Phosphorylation of signal transducer and activator of transcription-3 (Stat3) after focal cerebral ischemia in rats. Exp. Neurol. 170 (2001) 63-71