High-speed simultaneous determination of nine antiepileptic drugs using liquid chromatography-mass spectrometry

Therapeutic Drug Monitoring

Volumn 30, Issue 3, 2008, Pages 347-356

  Subramanian, Murali ^a   Birnbaum, Angela K ^a   Remmel, Rory P ^a,b  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Antiepileptic drugs (AEDs); Carbamazepine; Lamotrigine; LC MS; Simultaneous assay; Solid phase extraction; Zonisamide

Indexed keywords

10,11 DIHYDRO 10,11 DIHYDROXYCARBAMAZEPINE; ACETIC ACID; ACETONITRILE; ANTICONVULSIVE AGENT; CARBAMAZEPINE; CARBAMAZEPINE 10,11 OXIDE; FELBAMATE; GABAPENTIN; LAMOTRIGINE; LICARBAZEPINE; METHANOL; PHENOBARBITAL; PHENYTOIN; PREGABALIN; TETRAHYDROFURAN; TIAGABINE; TOPIRAMATE; VALPROIC ACID; ZONISAMIDE; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS;

ACCURACY; ARTICLE; ATMOSPHERIC PRESSURE; CALIBRATION; CORRELATION COEFFICIENT; DRUG DETERMINATION; DRUG MONITORING; DRUG PURIFICATION; DRUG QUALITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; ION MONITORING; LABORATORY; MASS SPECTROMETRY; PRIORITY JOURNAL; QUALITY CONTROL; SOLID PHASE EXTRACTION; STANDARD; BLOOD; DRUG COMBINATION; EPILEPSY; REPRODUCIBILITY; ULTRAVIOLET SPECTROPHOTOMETRY;

ANTICONVULSANTS; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG THERAPY, COMBINATION; EPILEPSY; HUMANS; INDICATORS AND REAGENTS; MASS SPECTROMETRY; QUALITY CONTROL; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 47249102459     PISSN: 01634356     EISSN: 15363694     Source Type: Journal    
DOI: 10.1097/FTD.0b013e3181678ecb     Document Type: Article

References (32)

1. Johannessen SI, Battino D, Berry DJ, et al. Therapeutic drug monitoring of the newer antiepileptic drugs. Ther Drug Monit. 2003;25:347-363.
2. Neels HM, Sierens AC, Naelaerts K, et al. Therapeutic drug monitoring of old and newer anti-epileptic drugs. Clin Chem Lab Med. 2004;42:1228-1255.
3. Soldin SJ, Hill JG. Rapid micromethod for measuring anticonvulsant drugs in serum by high-performance liquid chromatography. Clin Chem. 1976;22:856-859.
4. Kabra PM, Stafford BE, Marton LJ. Simultaneous measurement of phenobarbital, phenytoin, primidone, ethosuximide, and carbamazepine in serum by high-pressure liquid chromatography. Clin Chem. 1977;23: 1284-1288.
5. Christofides JA, Fry DE. Measurement of anticonvulsants in serum by reversed-phase ion-pair liquid chromatography. Clin Chem. 1980;26: 499-501.
6. Szabo GK, Browne TR. Improved isocratic liquid-chromatographic simultaneous measurement of phenytoin, phenobarbital, primidone, carbamazepine, ethosuximide, and N-desmethylmethsuximide in serum. Clin Chem. 1982;28:100-104.
7. Neels HM, Totte JA, Verkerk RM, et al. Simultaneous high performance liquid-chromatographic determination of carbamazepine, carbamazepine-10,11- epoxide, ethosuximide, phenobarbital, phenytoin, primidone and phenylethylmalonamide in plasma. J Clin Chem Clin Biochem. 1983;21: 295-299.
8. Ou CN, Rognerud CL. Simultaneous measurement of ethosuximide, primidone, phenobarbital, phenytoin, carbamazepine, and their bioactive metabolites by liquid chromatography. Clin Chem. 1984;30:1667-1670.
9. Juergens U. Simultaneous determination of Zonisamide and nine other anti-epileptic drugs and metabolites in serum. A comparison of microbore and conventional high-performance liquid chromatography. J Chromatogr. 1987;385:233-240.
10. Romanyshyn LA, Wichmann JK, Kucharczyk N, et al. Simultaneous determination of felbamate, primidone, phenobarbital, carbamazepine, two carbamazepine metabolites, phenytoin, and one phenytoin metabolite in human plasma by high-performance liquid chromatography. Ther Drug Monit. 1994;16:90-99.
11. Matar KM, Nicholls PJ, Tekle A, et al. Liquid chromatographic determination of six antiepileptic drugs and two metabolites in microsamples of human plasma. Ther Drug Monit. 1999;21:559-566.
12. Lancas FM, Sozza MA, Queiroz ME. Simultaneous plasma lamotrigine analysis with carbamazepine, carbamazepine 10,11 epoxide, primidone, phenytoin, phenobarbital, and PEMA by micellar electrokinetic capillary chromatography (MECC). J Anal Toxicol. 2003;27:304-308.
13. Breton H, Cociglio M, Bressolle F, et al. Liquid chromatographyelectrospray mass spectrometry determination of carbamazepine, oxcarbazepine and eight of their metabolites in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2005;828:80-90.
14. Britzi M, Soback S, Isoherranen N, et al. Analysis of topiramate and its metabolites in plasma and urine of healthy subjects and patients with epilepsy by use of a novel liquid chromatography-mass spectrometry assay. Ther Drug Monit. 2003;25:314-322.
15. Franceschi L, Furlanut M. A simple method to monitor plasma concentrations of oxcarbazepine, carbamazepine, their main metabolites and lamotrigine in epileptic patients. Pharmacol Res. 2005;51: 297-302.
16. Greiner-Sosanko E, Lower DR, Virji MA, et al. Simultaneous determination of lamotrigine, zonisamide, and carbamazepine in human plasma by high-performance liquid chromatography. Biomed Chromatogr. 2007;21:225-228.
17. Guo T, Oswald LM, Mendu DR, et al. Determination of levetiracetam in human plasma/serum/saliva by liquid chromatography-electrospray tandem mass spectrometry. Clin Chim Acta. 2007;375:115-118.
18. Levert H, Odou P, Robert H. LC determination of oxcarbazepine and its active metabolite in human serum. J Pharm Biomed Anal. 2002;28: 517-525.
19. Mandrioli R, Albani F, Casamenti G, et al. Simultaneous highperformance liquid chromatography determination of carbamazepine and five of its metabolites in plasma of epileptic patients. J Chromatogr B Biomed Sci Appl. 2001;762:109-116.
20. Mandrioli R, Ghedini N, Albani F, et al. Liquid chromatographic determination of oxcarbazepine and its metabolites in plasma of epileptic patients after solid-phase extraction. J Chromatogr B Analyt Technol Biomed Life Sci. 2003;783:253-263.
21. Miao XS, Yang JJ, Metcalfe CD. Carbamazepine and its metabolites in wastewater and in biosolids in a municipal wastewater treatment plant. Environ Sci Technol. 2005;39:7469-7475.
22. Remmel RP, Miller SA, Graves NM. Simultaneous assay of felbamate plus carbamazepine, phenytoin, and their metabolites by liquid chromatography with mobile phase optimization. Ther Drug Monit. 1990;12:90-96.
23. Yoshida T, Imai K, Motohashi S, et al. Simultaneous determination of zonisamide, carbamazepine and carbamazepine-10,11-epoxide in infant serum by high-performance liquid chromatography. J Pharm Biomed Anal. 2006;41:1386-1390.
24. Jain DS, Subbaiah G, Sanyal M, et al. Determination of levetiracetam in human plasma by liquid chromatography/electrospray tandem mass spectrometry and its application to bioequivalence studies. Rapid Commun Mass Spectrom. 2006;20:2539-2547.
25. Masucci JA, Ortegon ME, Jones WJ, et al. In vivo microdialysis and liquid chromatography/thermospray mass spectrometry of the novel anticonvulsant 2,3:4,5-bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate (topiramate) in rat brain fluid. J Mass Spectrom. 1998;33:85-88.
26. Chen S, Carvey PM. Rapid approach to the quantitative determination of topiramate (2, 3:4,5-bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate) in human plasma by liquid-liquid extraction and flowinjection negative-ion electrospray mass spectrometry. Rapid Commun Mass Spectrom. 1999;13:1980-1984.
27. Contin M, Riva R, Albani F, et al. Simple and rapid liquid chromatographic-turbo ion spray mass spectrometric determination of topiramate in human plasma. J Chromatogr B Biomed Sci Appl. 2001;761: 133-137.
28. Glajch JL, Kirkland JJ. Classification of multisolvent mobile phase systems in liquid chromatography. Analytical Chemistry. 1982;54:2593-2596.
29. Nelson MH, Birnbaum AK, Nyhus PJ, et al. A capillary GC-MS method for analysis of phenytoin and [13C3]-phenytoin from plasma obtained from pulse dose pharmacokinetic studies. J Pharm Biomed Anal. 1998;17: 1311-1323.
30. Food and Drug Administration. Guidance for Industry: Bioanalytical Method Validation. Rockville, MD: U.S. Department of Health and Human Services; 2001.
31. Rao DVG, Chakravarthy IE, Kumar SR. Stability indicating HPLC method for the determination of Zonisamide as bulk drug and in pharmaceutical dosage form. Chromatographia. 2006;64:261-266.
32. Volosov A, Bialer M, Xiaodong S, et al. Simultaneous stereoselective high-performance liquid chromatographic determination of 10-hydroxycarbazepine and its metabolite carbamazepine-10,11-trans-dihydrodiol in human urine. J Chromatogr B Biomed Sci Appl. 2000;738:419-425.