An essential ligand-binding domain in the membrane receptor for retinol-binding protein revealed by large-scale mutagenesis and a human polymorphism

Journal of Biological Chemistry

Volumn 283, Issue 22, 2008, Pages 15160-15168

  Kawaguchi, Riki ^a,b   Yu, Jiamei ^a,b   Wiita, Patrick ^a   Honda, Jane ^a   Sun, Hui ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b JULES STEIN EYE INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; ANIMAL CELL CULTURE; CELL MEMBRANES; DRUG PRODUCTS; POLYMORPHISM;

AFFINITY MEMBRANES; BINDING DOMAINS; BINDING PROTEINS; BIRTH DEFECTS; CELL SURFACES; DO-MAINS; FUNCTIONAL DOMAINS; MEMBRANE RECEPTORS; MEMBRANE TRANSPORT PROTEINS; NEW CLASSES; TARGET ORGANS; TRANSMEMBRANE DOMAINS;

BINDING SITES;

MEMBRANE RECEPTOR; PROTEIN STRA6; RETINOL; RETINOL BINDING PROTEIN; UNCLASSIFIED DRUG; MEMBRANE PROTEIN; PLASMA RETINOL BINDING PROTEIN; STRA6 PROTEIN, HUMAN;

ARTICLE; BINDING AFFINITY; BIRTH DEFECT; CELL SURFACE; CONTROLLED STUDY; DISEASE SEVERITY; GENETIC POLYMORPHISM; HUMAN; HUMAN CELL; MUTAGENESIS; MUTATION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN POLYMORPHISM; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS; ANIMAL; ANTIBODY SPECIFICITY; CATTLE; CELL LINE; CONGENITAL DISORDER; GENETICS; METABOLISM; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION;

ANIMALS; CATTLE; CELL LINE; CONGENITAL ABNORMALITIES; HUMANS; MEMBRANE PROTEINS; MUTAGENESIS; MUTATION; ORGAN SPECIFICITY; POLYMORPHISM, GENETIC; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RETINOL-BINDING PROTEINS, PLASMA; STRUCTURE-ACTIVITY RELATIONSHIP; VITAMIN A;

EID: 47249101742     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M801060200     Document Type: Article

References (37)

1. Goodman, D. S. (1984) in The Retinoids (Sporn, M. B., Boberts, A. B., and Goodman, D. S., eds) pp. 41-88, Academic Press, Orlando, FL
2. Newcomer, M. E., and Ong, D. E. (2000) Biochim. Biophys. Acta 1482, 57-64
3. Blaner, W. S. (1989) Endocr. Rev. 10, 308-316
4. Zanotti, G., and Berni, R. (2004) Vitam. Horm. 69, 271-295
5. Bok, D., and Heller, J. (1976) Exp. Eye Res. 22, 395-402
6. Heller, J. (1975) J. Biol. Chem. 250, 3613-3619
7. Heller, J., and Bok, D. (1976) Exp. Eye Res. 22, 403-410
8. Rask, L., and Peterson, P. A. (1976) J. Biol. Chem. 251, 6360-6366
9. Maraini, G., and Gozzoli, F. (1975) Investig. Ophthalmol. 14, 785-787
10. Chen, C. C., and Heller, J. (1977) J. Biol. Chem. 252, 5216-5221
11. Sivaprasadarao, A., and Findlay, J. B. (1988) Biochem. J. 255, 561-569
12. Smeland, S., Bjerknes, T., Malaba, L., Eskild, W., Norum, K. R., and Blomhoff, R. (1995) Biochem. J. 305, 419-424
13. Sivaprasadarao, A., Boudjelal, M., and Findlay, J. B. (1994) Biochem. J. 302, 245-251
14. MacDonald, P. N., Bok, D., and Ong, D. E. (1990) Proc. Natl. Acad. Sci. U. S. A. 87, 4265-4269
15. Shingleton, J. L., Skinner, M. K., and Ong, D. E. (1989) Biochemistry 28, 9641-9647
16. Bishop, P. D., and Griswold, M. D. (1987) Biochemistry 26, 7511-7518
17. Bhat, M. K., and Cama, H. R. (1979) Biochim. Biophys. Acta 587, 273-281
18. Davis, J. T., and Ong, D. E. (1995) Biol. Reprod. 52, 356-364
19. Hagen, E., Myhre, A. M., Smeland, S., Halvorsen, B., Norum, K. R., and Blomhoff, R. (1999) J. Nutr. Biochem. 10, 345-352
20. Torma, H., and Vahlquist, A. (1984) Arch. Dermatol. Res. 276, 390-395
21. Buck, J., Ritter, G., Dannecker, L., Katta, V., Cohen, S. L., Chait, B. T., and Hammerling, U. (1990) J. Exp. Med. 171, 1613-1624
22. Kawaguchi, R., Yu, J., Honda, J., Hu, J., Whitelegge, J., Ping, P., Wiita, P., Bok, D., and Sun, H. (2007) Science 315, 820-825
23. Bouillet, P., Sapin, V., Chazaud, C., Messaddeq, N., Decimo, D., Dolle, P., and Chambon, P. (1997) Mech. Dev. 63, 173-186
24. Szeto, W., Jiang, W., Tice, D. A., Rubinfeld, B., Hollingshead, P. G., Fong, S. E., Dugger, D. L., Pham, T., Yansura, D. G., Wong, T. A., Grimaldi, J. C., Corpuz, R. T., Singh, J. S., Frantz, G. D., Devaux, B., Crowley, C. W., Schwall, R. H., Eberhard, D. A., Rastelli, L., Polakis, P., and Pennica, D. (2001) Cancer Res. 61, 4197-4205
25. Bichet, D., Lin, Y. F., Ibarra, C. A., Huang, C. S., Yi, B. A., Jan, Y. N., and Jan, L. Y. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 4441-4446
26. Yi, B. A., Lin, Y. F., Jan, Y. N., and Jan, L. Y. (2001) Neuron 29, 657-667
27. Minor, D. L., Jr., Masseling, S. J., Jan, Y. N., and Jan, L. Y. (1999) Cell 96, 879-891
28. Pasutto, F., Sticht, H., Hammersen, G., Gillessen-Kaesbach, G., Fitzpatrick, D. R., Nurnberg, G., Brasch, F., Schirmer-Zimmermann, H., Tolmie, J. L., Chitayat, D., Houge, G., Fernandez-Martinez, L., Keating, S., Mortier, G., Hennekam, R. C., von der Wense, A., Slavotinek, A., Meinecke, P., Bitoun, P., Becker, C., Nurnberg, P., Reis, A., and Rauch, A. (2007) Am. J. Hum. Genet. 80, 550-560
29. Golzio, C., Martinovic-Bouriel, J., Thomas, S., Mougou-Zrelli, S., Grattagliano-Bessieres, B., Bonniere, M., Delahaye, S., Munnich, A., Encha-Razavi, F., Lyonnet, S., Vekemans, M., Attie-Bitach, T., and Etchevers, H. C. (2007) Am. J. Hum. Genet. 80, 1179-1187
30. Sekine-Aizawa, Y., and Huganir, R. L. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 17114-17119
31. Hsieh, J. C., Rattner, A., Smallwood, P. M., and Nathans, J. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 3546-3551
32. Dellis, O., Dedos, S. G., Tovey, S. C., Taufiq Ur, R., Dubel, S. J., and Taylor, C. W. (2006) Science 313, 229-233
33. Kawaguchi, R., Yu, J., Wiita, P., Ter-Stepanian, M., and Sun, H. (2008) Biochemistry, in press
34. Denning, G. M., Anderson, M. P., Amara, J. F., Marshall, J., Smith, A. E., and Welsh, M. J. (1992) Nature 358, 761-764
35. Seeliger, M. W., Biesalski, H. K., Wissinger, B., Gollnick, H., Gielen, S., Frank, J., Beck, S., and Zrenner, E. (1999) Investig. Ophthalmol. Vis. Sci. 40, 3-11
36. Folli, C., Viglione, S., Busconi, M., and Berni, R. (2005) Biochem. Biophys. Res. Commun. 336, 1017-1022
37. Collins, M. D., and Mao, G. E. (1999) Annu. Rev. Pharmacol. Toxicol. 39, 399-430