5-HT1A/1B receptors, α2 -adrenoceptors and the post-receptor adenylate cyclase activation in the mice brain are involved in the antidepressant-like action of agmatine

Yaoxue Xuebao

Volumn 43, Issue 5, 2008, Pages 467-473

  Jiang, Xian Zhong ^a   Li, Yun Feng ^a   Zhang, You Zhi ^a   Chen, Hong Xia ^a   Li, Ji ^a   Wang, Nai Ping ^a  

^a BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

Author keywords

2 adrenergic receptor; 5 HT 1A 1B receptors; Adenylate cyclase; Agmatine; Antidepressant; Forced swimming test; Tail suspension test

Indexed keywords

ADENYLATE CYCLASE; AGMATINE; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ANTIDEPRESSANT AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; FENCLONINE; IDAZOXAN; PINDOLOL; RECEPTOR; SEROTONIN 1A RECEPTOR; YOHIMBINE;

ANIMAL; ANIMAL BEHAVIOR; ARTICLE; DEPRESSION; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; MALE; METABOLISM; MOUSE; PATHOPHYSIOLOGY; RANDOMIZATION; RAT; SWIMMING; SYNAPSE; WISTAR RAT;

ADENYLATE CYCLASE; ADRENERGIC ALPHA-ANTAGONISTS; ADRENERGIC BETA-ANTAGONISTS; AGMATINE; ANIMALS; ANTIDEPRESSIVE AGENTS; BEHAVIOR, ANIMAL; DEPRESSION; DOSE-RESPONSE RELATIONSHIP, DRUG; FENCLONINE; IDAZOXAN; MALE; MICE; PINDOLOL; RANDOM ALLOCATION; RATS; RATS, WISTAR; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTORS, BIOGENIC AMINE; SWIMMING; SYNAPSES; YOHIMBINE;

EID: 47249093243     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Andrea D, Zomkowski A, Oscar Rosa A. Evidence for serotonin receptor subtypes involvement in agmatine antidepressant-like effect in the mouse forced swimming test [J]. Brain Res, 2004,1023:253-263.
2. Andrea D, Zomkowski AD, Santos AR, et al. Evidence for the involvement of the opioid system in the agmatine antidepressant-like effect in the forced swimming test [J]. Brain Res, 2005,381:279-283.
3. Li YF, Liu YQ, Huang WC, et al. Cytoprotective is one of the common action pathways for antidepressants [J], Acta Pharmacol Sin, 2003,24:996-1000.
4. Li YF, Chen HX, Liu Y, et al. Agmatine increases proliferation of cultured hippocampal progenitor cells and hippocampal neurogenesis in chronically stressed mice [J]. Acta Pharmacol Sin, 2006,27:1395-1400.
5. Li YF, Gong ZH, Cao JB, et al. Antidepressant-like effect of agmatine and its possible mechanism [J]. Eur J Pharmacol, 2003,469:81-88.
6. Li YF, Luo ZP. Depression: neuron lesion and neurogenesis down-regulation [J]. Acta Pharm Sin ( ), 2004,39:949-953.
7. Steru L. The tail suspension test : a new method for screening antidepressants in mice [J]. Psychopharma Cology, 1985,85:367-370.
8. Porsolt RD, Bertin A, Jalfre M , et al. Behavioral despair in mice; a primary screening test for anti-depressants [J]. Arch Int Pharmacodyn Ther, 1977,229:327-336.
9. Li YF, Liu YQ, Yang M, et al. Screening of the antidepressant components in aqueous extract of detoxified cottonseeds [J]. Bull Acad Mil Med Sci ( ), 2004,28:250-252.
10. Yang XC, Reis DJ. Agmatine selective block the N-methyl-D-aspartate subclass of glutamate receptor channels in rat hippocampal neurons [J]. J Pharmacol Exp Ther, 1999,288:544-549.
11. Pascoli V, Valjent E, Corbillé AG, et al. cAMP and extracellular signal-regulated kinase signaling in response to d-amphetamine and methylphenidate in the prefrontal cortex in vivo : role of beta 1 -adrenoceptors [J]. Mol Pharmacol, 2005,68:421-429.
12. Bell R, Hobson H. Effects of ( - )-pindolol and SDZ 216-525 on social and agonistic behavior in mice [J]. Pharmacol Biochem Behav, 1993,46:873-880.
13. Tokuyama S, Takahashi M, Kaneto H, et al. Involvement of serotoninergic receptor subtypes in the production of antinociception by psychological stress in mice [J]. Jpn J Pharmacol, 1993,61:237-242.
14. Rodgers RJ, Shepherd JK. Attenuation of defensive analgesia in male mice by 5-HT3 receptor antagonists, ICS 205-930, MDL 72222, MDL 73147EF and MDL 72699 [J]. Neuropharmacology, 1992,31:553-560.
15. Ghelardini C, Galeotti N, Bartolini A. Antinociception induced by amitriptyline and imipramine is mediated by alpha2A-adrenoceptors [J]. Jpn J Pharmacol, 2000,82:130-137.
16. Airio J, Ahtee L. The involvement of noradrenergic transmission in the morphine-induced locomotor hyperactivity in mice withdrawn from repeated morphine treatment [J]. Br J Pharmacol, 1999,126:1609-1619.
17. Pariante CM, Kim RB, Makoff A, et al. Antidepressant fluoxetine enhances glucocorticoid receptor function in vitro by modulating membrane steroid transporters [J]. Br J Pharmacol, 2003,139:1111-1118.
18. Rick CE, Stanford IM, Lacey MG. Excitation of rat substantia nigra and pars reticulata neurons by 5-hydroxytryptamine in vitro; evidence for a direct action mediated by 5-hydroxytryptamine 2C receptors [J]. Neuroscience, 1995,69:903-913.
19. Luo M, Fink GD, Lookingland KJ, et al. Impaired function of alpha2-adrenergic autoreceptors on sympathetic nerves associated with mesenteric arteries and veins in DOCA-salt hypertension [J]. Am J Physiol Heart Circ Physiol, 2004,286:H1558-1564.
20. Yamboliev IA, Mutafova-Yambolieva VN. PI3K and PKC contribute to membrane depolarization mediated by alpha2-adrenoceptors in the canine isolated mesenteric vein [J]. BMC Physiol, 2005,Jun 15:5-9.
21. Zomkowski AD, Hammes L, Lin J, et al. Agmatine produces antidepressant-like effects in two models of depression in mice [J]. Neuroreport, 2002,13:387-391.
22. Zeidan MP, Zomkowski AD, Rosa AO, et al. Evidence for imidazoline receptors involvement in the agmatine antidepressant-like effect in the forced swimming test [J]. Eur J Pharmacol, 2007,565:125-131.
23. Johansson L, Sohn D, Thorberg SO, et al. The pharmacological characterization of a novel selective 5-hydroxytryptamine 1A receptor antagonist NAD-299 [J]. J Pharmacol Exp Ther, 1997,283:216-225.
24. Li YF, Gong ZH, Zhang HT, et al. Antidepressant agents on the impact of activity of adenylate cyclase from rats prefrontal cortex [J]. Bull Acad Mil Med Sci ( ), 1999,23:130-132.
25. Chen J, Rasenick MM. Chronic antidepressant treatment facilitates G protein activation of adenylyl cyclase without altering G protein content [J]. J Pharmacol Exp Ther, 1995,275:509-517.
26. Ozawa H, Ra senick MM. Coupling of the stimulatory GTP-binding protein Gs to rat synaptic membrane adenylyl cyclase is enhanced subsequent to chronic antidepressant treatment [J]. Mol Pharmacol, 1989,36; 803-808.
27. Kuznetsova L, Plesneva S, Derjabina N, et al. On the mechanism of relaxin action : the involvement of adenylyl cyclase signalling system [I]. Regul Pept, 1999,80:33-39.