Toxic effects of l-aspartic acid at high dose levels on kidneys and salivary glands in Fischer 344 rats detected in a 90-day feeding study

Food and Chemical Toxicology

Volumn 46, Issue 8, 2008, Pages 2789-2795

  Tada, Y ^a   Yano, N ^a   Takahashi, H ^a   Yuzawa, K ^a   Ando, H ^a   Kubo, Y ^a   Nagasawa, A ^a   Uehara, S ^a   Ogata, A ^a   Nakae, D ^a  

^a TOKYO METROPOLITAN INSTITUTE OF PUBLIC HEALTH   (Japan)

Author keywords

Feeding study; Fischer 344 rat; l Aaspartic acid; Renal toxicity; Salivary glands toxicity; Subchronic toxicity test

Indexed keywords

ALPHA 2 GLOBULIN; ASPARTIC ACID; CREATININE; KETONE; URIC ACID;

ACINAR CELL; ADVERSE OUTCOME; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; CAUSAL ATTRIBUTION; CHRONIC TOXICITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIET; EXPERIMENTAL STUDY; FEEDING; FEMALE; FISCHER 344 RAT; HEMATOLOGY; HISTOPATHOLOGY; HYPERTROPHY; KIDNEY INJURY; KIDNEY MASS; KIDNEY TUBULE; MALE; NEPHROTOXICITY; NONHUMAN; PROTEIN URINE LEVEL; RAT; SALIVARY GLAND; TISSUE REGENERATION; UREA NITROGEN BLOOD LEVEL; URIC ACID BLOOD LEVEL; URINALYSIS;

ANIMALS; ASPARTIC ACID; BLOOD CELL COUNT; BLOOD CHEMICAL ANALYSIS; BODY WEIGHT; DIET; DRINKING; EATING; FEMALE; KIDNEY; KIDNEY DISEASES; MALE; NO-OBSERVED-ADVERSE-EFFECT LEVEL; RATS; RATS, INBRED F344; SALIVARY GLAND DISEASES; SALIVARY GLANDS; URINALYSIS;

ANIMALIA; RATTUS;

EID: 47149113964     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2008.05.013     Document Type: Article

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