Drowning-out crystallization of l-proline: Effect of anti-solvent composition and processing parameters on crystal size and shape

Powder Technology

Volumn 186, Issue 2, 2008, Pages 137-144

  Hyung, Woochan ^a   Kim, Yehoon ^a,c   Chung, Chan Hwa ^b   Haam, Seungjoo ^a  

^a Yonsei University   (South Korea)

^b Sungkyunkwan University   (South Korea)

^c LG Chemical Ltd   (South Korea)

Author keywords

Agglomeration; Anti solvent; Drowning out; l proline; Transformation; Ultrasound

Indexed keywords

ACCIDENTS; ACETONE; ACOUSTIC WAVES; CRYSTALLIZATION; CRYSTALLOGRAPHY; DRUG PRODUCTS; EMULSIONS; FLUIDS; NANOCRYSTALLINE ALLOYS; PHASE SEPARATION; POWDERS; PRECIPITATION (CHEMICAL); SEPARATION; SOLUBILITY; TERNARY SYSTEMS; ULTRASONIC TRANSMISSION; ULTRASONICS;

AGGLOMERATE SIZES; ANTI-SOLVENTS; CRYSTAL SIZES; ELSEVIER (CO); EMULSION DROPLETS; GENERAL (CO); HIGH WATER; IMMISCIBLE PHASES; L-PROLINE (PRO); MONO-CRYSTALS; PRECIPITATION (METALLOGRAPHY); PROCESSING PARAMETERS; RESIDENCE TIME (RT); SOLUBILITY STUDIES; SOLUBILITY TESTS; SOLVENT COMPOSITIONS; SOLVENT DIFFUSION METHODS; SPHERICAL(PIVOT); SURFACE TRANSFORMED;

SOLVENTS;

1 PYRROLIDINECARBONITRILE; ACETONE; CYANIDE; METHYLPYRROLIDINE; PROLINE; SOLVENT; SUCCINIMIDE DERIVATIVE;

ARTICLE; CHEMICAL COMPOSITION; CRYSTAL; CRYSTALLIZATION; DIFFUSION; EMULSION; MISCIBILITY; MORPHOLOGY; PHASE SEPARATION; PRECIPITATION; SOLUBILITY; SURFACE PROPERTY; ULTRASOUND;

EID: 47049128084     PISSN: 00325910     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.powtec.2007.11.007     Document Type: Article

References (15)

1. Beckmann W. Nucleation phenomena during the crystallization and precipitation of Abecarnil. J. Cryst. Growth 198-199 (1999) 1287-1293
2. Myerson A.S. Handbook of Industrial Crystallization (1993), Butterworth-Heinemann, London
3. David A.B., Susan R.D., and Ka M.N. Synthesis of drowning-out crystallization-based separations. AIChE J. 43 (1997) 91-103
4. Charmolue H., and Rousseau R.W. l-serine obtained by methanol addition in batch crystallization. AIChE J. 37 (1991) 1121-1128
5. Revesz P.S., Goczo H., and Hodi K.P. Development of spherical crystal agglomerates of an aspartic acid salt for direct tablet making. Powder Technol. 114 (2001) 118-124
6. Kim Y.H., Haam S., Shul Y.G., Kim W.S., Jung J.K., Eun H.-C., and Koo K.-K. Pseudopolymorphic crystallization of l-ornithine-l-aspartate by drowning out. IEC 42 (2003) 883-889
7. Kim Y.H., Haam S., Kim W.S., and Koo K.-K. Parameters determining the agglomeration behavior of anhydrous LOLA crystals prepared by drowning out crystallization. KJChE 20 6 (2003) 1111-1117
8. Brittain H.G. Polymorphism in Pharmaceutical Solids (1999), Marcel Dekker, New York
9. Kawashima Y., Okumura M., and Takenaka H. Spherical crystallization: direct spherical agglomeration of salicylic acid crystals during crystallization. Science 216 (1982) 1127-1128
10. Chulia D., Deleuil M., and Pourcelot Y. Powder Technology and Pharmaceutical Processes (1994), Elsevier, Amsterdam
11. Greenstein J.P., and Winitz M. Chemistry of the Amino Acid vol. 1 (1984), Krieger Publishing Company, Florida
12. Petr K., Jun-Wei S., Akio T., and Takeshi I. Solvent selection for pharmaceuticals. Fluid Phase Equilib. 194-197 (2002) 771-782
13. Mulline J.W. Crystallization (1993), Butterworth-Heinemann, London
14. Pina C.M., Fernadez-Diaz L., Prieto M., and Veintemillas-Verdaguer S. Metastability in drowning-out crystallization: precipitation of highly soluble sulphates. J. Cryst. Growth 222 (2001) 317-327
15. Mason T.J., and Lorimer J.P. Sonochemistry Theory, Applications and Uses of Ultrasound in Chemistry (1989), Wiley-Interscience, New York