Short telomeres in B-CLL: The chicken or the egg?

Blood

Volumn 111, Issue 12, 2008, Pages 5756-

  Jahrsdörfer, Bernd ^a   Weiner, George J ^a  

^a UNIVERSITY OF ULM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN BCL 2; TELOMERASE;

B CELL LEUKEMIA; CHROMOSOME ABERRATION; CHRONIC LYMPHATIC LEUKEMIA; ENZYME ACTIVITY; HUMAN; LETTER; LEUKEMOGENESIS; PRIORITY JOURNAL; PROGNOSIS; TELOMERE; CELL TRANSFORMATION; GENETICS; NOTE;

CELL TRANSFORMATION, NEOPLASTIC; CHROMOSOME ABERRATIONS; HUMANS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; TELOMERE;

EID: 47049121824     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2008-03-146027     Document Type: Letter

References (6)

1. Roos G, KroberA, Grabowski P, et al. Short telomeres are associated with genetic complexity, high-risk genomic aberrations, and short survival in chronic lymphocytic leukemia. Blood. 2008;111:2246-2252.
2. Akbar AN, Vukmanovic-Stejic M. Telomerase in T lymphocytes: use it and lose it? J Immunol. 2007;178:6689-6694.
3. Weng NP. Telomere and adaptive immunity. Mech Ageing Dev. 2008;129:60-66.
4. Messmer BT, Messmer D, Allen SL. et al. In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells. J Glin Invest. 2005;115:755-764.
5. Longo PG, Laurenti L, Gobessi S, et al. The Akt signaling pathway determines the different proliferative capacity of chronic lymphocytic leukemia B-cells from patients with progressive and stable disease. Leukemia. 2007;21:110-120.
6. Jahrsdörfer B, Wooldridge JE, Blackwell SE, Taylor CM, Link BK, Weiner GJ. Good prognosis cytogenetics in B-cell chronic lymphocytic leukemia is associated in vitro with lowsusceptibilityto apoptosis and enhanced immunogenicity. Leukemia. 2005;19:759-766.