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Volumn 47, Issue 22, 2008, Pages 4054-4056

Implications of a carboxylate-bound C-cluster structure of carbon monoxide dehydrogenase

Author keywords

Bioinorganic chemistry; Carbon dioxide fixation; Enzyme catalysis; Metalloenzymes; Nickel

Indexed keywords

CARBON MONOXIDE; CARBOXYLATION; ENZYMES;

EID: 47049118229     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200800223     Document Type: Short Survey
Times cited : (26)

References (23)
  • 1
    • 84954622001 scopus 로고    scopus 로고
    • Eds, A. Sigel, H. Sigel, R. K. O. Sigel, Wiley, Chichester, UK
    • P. A. Lindahl, D. E. Graham in Metal Ions in Life Sciences, Vol. 2 (Eds.: A. Sigel, H. Sigel, R. K. O. Sigel), Wiley, Chichester, UK, 2007, pp. 357-416.
    • (2007) Metal Ions in Life Sciences , vol.2 , pp. 357-416
    • Lindahl, P.A.1    Graham, D.E.2
  • 16
    • 53549106458 scopus 로고    scopus 로고
    • Jeoung and Dobbek report a third structure (of a sample poised at -600 mV, which should correspond to the Cred2 state. A bridging OH, group is observed, which seems incongruent with previous spectroscopic studies and is difficult to understand mechanistically. If CO 2 binds to the Cred2 state, to form Ni-CO and Ni-OH-Fea, the bridging site needs to be vacant prior to that formation. One possibility is that water is displaced as CO2 binds. Another possibility is that the structure is actually of the Cred1 state, and that the sample became oxidized during crystallization. There is a reported tendency of CODH solutions to oxidize spontaneously [17] and the possibility should be considered that this occurred during the time required to obtain crystals. The structures reported for ACS/CODHMt (prepared in 1 atm CO) do not show H2O bound,[5, 6] which is cons
    • red2 state.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.