Recombinant human interleukin-2 inhalation powders: Preparation and distribution in the alveolus

International Journal of Pharmaceutics

Volumn 360, Issue 1-2, 2008, Pages 225-227

  Yue, Tang ^a   Jia bi, Zhu ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

In situ pharmacokinetic model; Inhalation powders; Preparation; Recombinant human interleukin 2 (rhIL 2)

Indexed keywords

RECOMBINANT INTERLEUKIN 2;

ANIMAL CELL; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; COMPARTMENT MODEL; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EFFECT; DRUG HALF LIFE; DRUG TISSUE LEVEL; FEMALE; LUNG ALVEOLUS; LUNG ALVEOLUS EPITHELIUM; LUNG ALVEOLUS MACROPHAGE; NONHUMAN; PARAMETER; PARTICLE SIZE; POWDER; PRIORITY JOURNAL; RAT; WISTAR RAT;

ADMINISTRATION, INHALATION; ALGORITHMS; ANIMALS; CHEMISTRY, PHARMACEUTICAL; DESICCATION; DRUG COMPOUNDING; FEMALE; INTERLEUKIN-2; MACROPHAGES, ALVEOLAR; PARTICLE SIZE; POWDERS; PULMONARY ALVEOLI; RATS; RATS, WISTAR; RECOMBINANT PROTEINS; RESPIRATORY MUCOSA;

EID: 47049110322     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2008.04.024     Document Type: Article

References (10)

1. Bi A.H. Cytokines. Medicinal Immunology (2001), The People's Surgeon Press, Beijing pp. 332-340
2. Cadee J.A., de Groot C.J., Jiskoot W., den Otter W., and Hennink W.E. Release of recombinant human interleukin-2 from dextran-based hydrogels. J. Control. Release 78 (2002) 1-13
3. Choi I.S., and Yoo H.S. Expression of recombinant porcine interleukin-2 and application of its antibody to immunoassays. J. Vet. Sci. 3 (2002) 207-212
4. Marshall T., and Williams K.M. Interference in the Coomassie Brilliant Blue and Pyrogallol Red protein dye-binding assays is increased by the addition of sodium dodecyl sulfate to the dye reagents. Anal. Biochem. 331 (2004) 255-259
5. Poyner E.A., Alpar H.O., Almeida A.J., Gamble M.D., and Brown M.R.W. A comparative study on the pulmonary delivery of tobramycin encapsulated into liposomes and PLA microspheres following intravenous and endotracheal delivery. J. Control. Release 35 (1995) 41-48
6. Sun J., Deguchi Y., Tauchi Y., He Z., Cheng G., and Morimoto K. Distribution characteristics of orally administered olamufloxacin, a newly synthesized fluoroquinolone antibacterial, in lung epithelial lining fluid and alveolar macrophage in rats. Eur. J. Pharm. Biopharm. 64 (2006) 238-245
7. Tang Y., Zhu J.B., Cheng D.S., Zhang X.S., Zhou B., and Shen H.Y. Effect of rhIL-2 in inhalant form on experimental respiratory tract infection with Klebsiella pneumonia in mice. Acta Pharm. Sin. 40 (2005) 17-21
8. Telko M.J., and Hickey A.J. Dry powder inhaler formulation. Respir. Care 50 (2005) 1209-1227
9. Ten R.M., and Anderson P.M. Interleukin-2 liposomes for primary immune deficiency using the aerosol route. Int. Immunopharmacol. 2 (2002) 333-344
10. Zhu J.B., and Koizumi T. An overture for the improvement of least square adjustment with mini-computer. Yakugaku Zasshi 102 (1982) 352-358