The structural basis for allosteric inhibition of a threonine-sensitive aspartokinase

Journal of Biological Chemistry

Volumn 283, Issue 23, 2008, Pages 16216-16225

  Liu, Xuying ^a   Pavlovsky, Alexander G ^a   Viola, Ronald E ^a  

^a UNIVERSITY OF TOLEDO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; AMINO ACIDS; BINDING SITES; BIOCHEMICAL ENGINEERING; BIOCHEMISTRY; ENZYMES; ESCHERICHIA COLI; NUCLEIC ACIDS; OLIGOMERS; ORGANIC ACIDS;

ALLOSTERIC INHIBITIONS; ALLOSTERIC REGULATIONS; ALTERNATIVE SUBSTRATES; ASPARTATE; ASPARTIC ACIDS; ASPARTOKINASE; COOPERATIVE BINDINGS; DOMAIN MOVEMENTS; END PRODUCTS; ENZYME STRUCTURES; FEEDBACK REGULATIONS; INACTIVE CONFORMATIONS; METHANOCOCCUS JANNASCHII; MONOFUNCTIONAL; QUATERNARY STRUCTURES; RECOMBINANT ENZYMES; REGIOSPECIFICITY; STRUCTURAL BASES; STRUCTURAL EVIDENCES;

SUBSTRATES;

ASPARTATE KINASE; THREONINE; ARCHAEAL PROTEIN; RECOMBINANT PROTEIN;

ALLOSTERISM; ARTICLE; BINDING SITE; CONTROLLED STUDY; ENZYME BINDING; ENZYME INHIBITION; ENZYME STRUCTURE; ESCHERICHIA COLI; NONHUMAN; PRIORITY JOURNAL; CHEMISTRY; DIMERIZATION; ENZYME SPECIFICITY; ENZYMOLOGY; GENETICS; METHANOCOCCUS; PHYSIOLOGY; PROTEIN QUATERNARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION;

ESCHERICHIA COLI; METHANOCALDOCOCCUS JANNASCHII;

ALLOSTERIC REGULATION; ARCHAEAL PROTEINS; ASPARTATE KINASE; DIMERIZATION; METHANOCOCCUS; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; THREONINE;

EID: 47049099444     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M800760200     Document Type: Article

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