Structural and functional effects of hereditary hemolytic anemia-associated point mutations in the alpha spectrin tetramer site

Blood

Volumn 111, Issue 12, 2008, Pages 5712-5720

  Gaetani, Massimiliano ^a   Mootien, Sara ^b   Harper, Sandra ^a   Gallagher, Patrick G ^b   Speicher, David W ^a  

^a WISTAR INSTITUTE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FODRIN; MUTANT PROTEIN; RECOMBINANT PROTEIN; TETRAMER; SPECTRIN;

ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; HEMOLYTIC ANEMIA; HEREDITARY ELLIPTOCYTOSIS; HEREDITARY PYROPOIKILOCYTOSIS; HUMAN; HUMAN CELL; MUTATIONAL ANALYSIS; POINT MUTATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN STRUCTURE; WILD TYPE; AMINO ACID SEQUENCE; CHEMISTRY; CIRCULAR DICHROISM; DIFFERENTIAL SCANNING CALORIMETRY; ENTROPY; ERYTHROCYTE; GENE EXPRESSION; GENETICS; GENOTYPE; HEREDITARY HEMOLYTIC ANEMIA; MASS SPECTROMETRY; METABOLISM; MOLECULAR GENETICS; PHENOTYPE; PHYSIOLOGY; PROTEIN BINDING; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANEMIA, HEMOLYTIC, CONGENITAL; BINDING SITES; CALORIMETRY, DIFFERENTIAL SCANNING; CIRCULAR DICHROISM; ENTROPY; ERYTHROCYTES; GENE EXPRESSION; GENOTYPE; HUMANS; MOLECULAR SEQUENCE DATA; PHENOTYPE; POINT MUTATION; PROTEIN BINDING; RECOMBINANT PROTEINS; SPECTRIN; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 47049089420     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2007-11-122457     Document Type: Article

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