Preclinical characterisation of NSAIDs in ultradeformable carriers or conventional topical gels

International Journal of Pharmaceutics

Volumn 360, Issue 1-2, 2008, Pages 29-39

  Cevc, Gregor ^a   Mazgareanu, Stefan ^a   Rother, Matthias ^a  

^a IDEA AG   (Germany)

Author keywords

Biodistribution; Drug delivery via the skin; Ketoprofen; Targeted analgesic, Diractin ; Ultradeformable lipid vesicle, Transfersome

Indexed keywords

DIRACTIN; GABRILEN; KETOPROFEN; KETOPROFEN RATIOPHARM; TRANSFERSOME;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BOAR (MALE PIG); CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG TISSUE LEVEL; DRUG TRANSPORT; GEL; IN VITRO STUDY; IN VIVO STUDY; LIPID VESICLE; MALE; NONHUMAN; PIGLET; PRIORITY JOURNAL;

ADMINISTRATION, ORAL; ADMINISTRATION, TOPICAL; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIFFUSION; DIFFUSION CHAMBERS, CULTURE; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; EXCIPIENTS; GELS; HUMANS; KETOPROFEN; MALE; SPECTROPHOTOMETRY, ULTRAVIOLET; SWINE; SWINE, MINIATURE; TISSUE DISTRIBUTION;

EID: 47049083493     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2008.01.051     Document Type: Article

References (41)

1. Borga O., and Borga B. Serum protein binding of nonsteroidal antiinflammatory drugs: a comparative study. J. Pharmacokinet. Biopharm. 25 (1997) 63-77
2. Cagnie B., Vinck E., Rimbaut S., and Vanderstraeten G. Phonophoresis versus topical application of ketoprofen: comparison between tissue and plasma levels. Phys. Ther. 83 (2003) 707-712
3. Cevc G. Lipid suspensions on the skin. Permeation enhancement, vesicle penetration and transdermal drug delivery. Crit. Rev. Therap. Drug Carrier Syst. 13 (1996) 257-388
4. Cevc G. Drug delivery across the skin. Exp. Opin. Invest. Drugs 6 (1997) 1887-1937
5. ®-innovative transdermal drug carriers. In: Rathbone M., Roberts M., and Hadgraft J. (Eds). Modified Release Drug Delivery Technology (2002), M. Dekker, New York 533-546
6. Cevc G. Lipid vesicles and other colloids as drug carriers on the skin. Adv. Drug Deliv. Rev. 56 (2004) 675-711
7. Cevc G., and Blume G. New, highly efficient formulation of diclofenac for the topical, transdermal administration in ultradeformable drug carriers, Transfersomes. Biochim. Biophys. Acta 1514 (2001) 191-205
8. Cevc G., and Gebauer D. Hydration driven transport of deformable lipid vesicles through fine pores and the skin barrier. Biophys. J. 84 (2003) 1010-1024
9. Cevc, G., Mazgareanu, S., Rother, M. Vierl, U. Occlusion effect on transcutaneous NSAID delivery from conventional and carrier-based formulations, Int. J. Pharm., submitted for publication.
10. Cevc G., Schätzlein A., and Richardsen H. Ultradeformable lipid vesicles can penetrate the skin and other semi-permeable barriers intact. Evidence from double label CLSM experiments and direct size measurements. Biochim. Biophys. Acta 1564 (2002) 21-30
11. ®, liposomes or mixed lipid micelles. Langmuir 19 (2003) 10753-10763
12. Cevc G., and Vierl U. Spatial distribution of cutaneous microvasculature, its depth profile, and local drug clearance after topical drug application on the skin. J. Contr. Rel. 118 (2007) 18-26
13. Cevc G., Vierl U., and Mazgareanu S. Functional characterisation of novel analgesic product based on self-regulating drug carriers. Int. J. Pharm. 360 (2008) 18-28
14. Clough G.F., Boutsiouki P., Church M.K., and Michel C.C. Effects of blood flow on the in vivo recovery of a small diffusible molecule by microdialysis in human skin. J. Pharm. Exp. Ther. 302 (2002) 681-686
15. Dowling T.C., Arjomand M., Lin E.T., Allen Jr. L.V., and McPherson M.L. Relative bioavailability of ketoprofen 20% in a poloxamer-lecithin organogel. Am. J. Health Syst. Pharm. 61 (2004) 2541-2544
16. FDA (Food and Drug Administration) CDER, 1997. Guidance for industry. Nonsterile semisolid dosage forms. Scale-up and post-approval changes. Chemistry, manufacturing and controls; in vitro release testing and in vivo bioequivalence documentation. http://www.fda.gov/cder/guidance.htm.
17. Figueras A., Capella D., Castel J.M., and Laorte J.R. Spontaneous reporting of adverse drug reactions to non-steroidal anti-inflammatory drugs. A report from the Spanish System of Pharmacovigilance, including an early analysis of topical and enteric-coated formulations. Eur. J. Clin. Pharmacol. 47 (1994) 297-303
18. Flouvat B., Roux A., and Delhotal-Landes B. Pharmacokinetics of ketoprofen in man after repeated percutaneous administration. Arzneimittelforschung 39 (1989) 812-815
19. Godin B., and Touitou E. Ethosomes: new prospects in transdermal delivery. Crit. Rev. Therap. Drug Carrier Syst. 20 (2003) 63-102
20. Hadgraft J., de Plessis J., and Goosen C. The selection of non-steroidal anti-inflammatory agents for dermal delivery. Int. J. Pharm. 207 (2000) 31-37
21. Heyneman C.A., Lawless-Liday C., and Wall G.C. Oral versus topical NSAIDs in rheumatic diseases: a comparison. Drugs 60 (2000) 555-574
22. Higaki K., Asai M., Suyama T., Nakayama K., Ogawara K., and Kimura T. Estimation of intradermal disposition kinetics of drugs: II. Factors determining penetration of drugs from viable skin to muscular layer. Int. J. Pharm. 239 (2002) 129-141
23. Jain S., Jain N., Bhadra D., Tiwary A.K., and Jain N.K. Transdermal delivery of an analgesic agent using elastic liposomes: preparation, characterization and performance evaluation. Curr. Drug Deliv. 2 (2005) 223-233
24. Kantor T.G. Ketoprofen: a review of its pharmacologic and clinical properties. Pharmacotherapy 6 (1986) 93-103
25. Kretsos K., and Kasting G.B. Dermal capillary clearance: physiology and modelling. Skin Pharmacol. Physiol. 18 (2005) 55-74
26. Lees P., Giraudel J., Landoni M.F., and Toutain P.L. PK/PD integration and PK/PD modelling of nonsteroidal anti-inflammatory drugs: principles and applications in veterinary pharmacology. J. Vet. Pharmacol. Ther. 27 (2004) 491-502
27. Lin J., Zhang W., Jones A., and Doherty M. Efficacy of topical non-steroidal anti-inflammatory drugs in the treatment of osteoarthritis: meta-analysis of randomised controlled trials. Br. Med. J. 329 (2004) 324-330
28. Maestrelli F., Gonzalez-Rodriguez M.L., Rabasco A.M., and Mura P. Preparation and characterisation of liposomes encapsulating ketoprofen-cyclodextrin complexes for transdermal drug delivery. Int. J. Pharm. 298 (2005) 55-67
29. Meyer W. Bemerkungen zur Eignung der Schweinehaut als biologisches Modell für die Haut des Menschen. Hautarzt 47 (1996) 178-182
30. Monteiro-Riviere N.A., Inman A.O., Riviere J.E., and McNeil S.C. Topical penetration of piroxicam is dependent on the distribution of the local cutaneous vasculature. Pharm. Res. 10 (1993) 1326-1331
31. Panus P.C., Ferslew K.E., Tober-Meyer B., and Kao R.L. Ketoprofen tissue permeation in swine following cathodic iontophoresis. Phys. Ther. 79 (1999) 40-49
32. Radermacher J., Jentsch D., Scholl M.A., Lustinetz T., and Frolich J.C. Diclofenac concentration in synovial fluid and plasma after cutaneous application in inflammatory and degenerative joint disease. Br. J. Clin. Pharmacol. 31 (1991) 537-541
33. Ricci M., Puglia C., Bonina F., Di Giovanni C., Giovagnoli S., and Rossi C. Evaluation of indomethacin percutaneous absorption from nanostructured lipid carriers (NLC): in vitro and in vivo studies. J. Pharm. Sci. 94 (2005) 1149-1159
34. Shah A.K., Wei G., Lanman R.C., Bhargava V.O., and Weir S.J. Percutaneous absorption of ketoprofen from different anatomical sites in man. Pharm. Res. 13 (1996) 168-172
35. Singh P., and Roberts M.S. Skin permeability and local tissue concentrations of nonsteroidal anti-inflammatory drugs after topical application. J. Pharmacol. Exp. Ther. 268 (1994) 144-151
36. Singh P., and Roberts M.S. Dermal and underlying tissue pharmacokinetics of lidocaine after topical application. J. Pharm. Sci. 83 (1994) 774-782
37. Tegeder I., Lötsch J., Kinzig-Schippers M., Sörgel F., Kelm G.R., Meller S.T., and Geisslinger G. Comparison of tissue concentrations after intramuscular and topical administration of ketoprofen. Pharm. Res. 18 (2001) 980-986
38. Vaile J.H., and Davis P. Topical NSAIDs for musculoskeletal conditions: a review of the literature. Drugs 56 (1998) 783-799
39. Valenta C., Wanka M., and Heidlas J. Evaluation of novel soya-lecithin formulations for dermal use containing ketoprofen as a model drug. J. Contr. Rel. 63 (2000) 165-173
40. Vardaxis N.J., Brans T.A., Boon M.E., Kreis R.W., and Marres L.M. Confocal laser scanning microscopy of porcine skin: implications for human wound healing studies. J. Anat. 190 (1997) 601-611
41. In: Walters K.A., and Hadgraft J. (Eds). Pharmaceutical Skin Penetration Enhancement (1993), Marcel Dekker, New York