Development and validation of a sensitive LC-MS/MS method with electrospray ionization for quantitation of doxofylline in human serum: Application to a clinical pharmacokinetic study

Biomedical Chromatography

Volumn 22, Issue 6, 2008, Pages 654-661

  Sreenivas, Nimmagadda ^a,b   Narasu, M Lakshmi ^a   Shankar, B Prabha ^c   Mullangi, Ramesh ^d  

^a JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY   (India)

^b Sarojini Naidu Vanitha Maha Vidyalaya   (India)

^c Eurodrug Laboratories India   (India)

^d DR REDDY'S LABORATORIES LTD   (India)

Author keywords

Doxofylline; Human serum; LC MS MS; Pharmacokinetics; Validation

Indexed keywords

ACETONITRILE; BODY FLUIDS; PHARMACOKINETICS;

CLINICAL PHARMACOKINETICS; DOXOFYLLINE; HUMAN SERUM; INTERNAL STANDARDS; IONIZATION TECHNIQUES; LC-MS-MS; LC.MS/MS; MULTIPLE-REACTION MONITORING MODES; PHARMACOKINETIC STUDIES; VALIDATION;

ELECTROSPRAY IONIZATION;

ACETONITRILE; DOXOFYLLINE; FORMIC ACID; IMIPRAMINE;

ACCURACY; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CORRELATION COEFFICIENT; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG HALF LIFE; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; ELUTION; HUMAN; HUMAN EXPERIMENT; LIQUID CHROMATOGRAPHY; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; PRECIPITATION; QUANTITATIVE ANALYSIS; SENSITIVITY AND SPECIFICITY; SEPARATION TECHNIQUE; STRUCTURE ANALYSIS; TABLET FORMULATION; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

EID: 46949089556     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.984     Document Type: Article

References (6)

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