Detection of epidermal growth factor receptor gene mutations in non-small cell lung cancers by real-time polymerase chain reaction using scorpion amplification refractory mutation system

Chinese Journal of Pathology

Volumn 37, Issue 5, 2008, Pages 294-299

  Zhang, Jing ^a   Liang, Zhi Yong ^a   Zeng, Xuan ^a   Wu, Sha Fei ^a   Gao, Jie ^a   Liu, Tong Hua ^a  

^a PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

Author keywords

Carcinoma, non small cell lung; Polymerase chain reaction; Receptor, epidermal growth factor

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; PARAFFIN; PROTEIN TYROSINE KINASE; CODON; SCORPION VENOM;

ACCURACY; ADULT; AGED; AMPLIFICATION REFRACTORY MUTATION SYSTEM; ANALYTIC METHOD; ARTICLE; CANCER PATIENT; CODON; CONTROLLED STUDY; DNA EXTRACTION; EXON; FEMALE; GENDER; GENE DELETION; GENE INSERTION; GENE MUTATION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; INCIDENCE; INTERMETHOD COMPARISON; LUNG ADENOCARCINOMA; LUNG NON SMALL CELL CANCER; LUNG PARENCHYMA; MAJOR CLINICAL STUDY; MALE; MICRODISSECTION; POINT MUTATION; POLYMERASE CHAIN REACTION; PROGNOSIS; PROTEIN DOMAIN; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR GENE; SENSITIVITY AND SPECIFICITY; SOMATIC MUTATION; TUMOR CELL; ADENOCARCINOMA; CHEMISTRY; GENE AMPLIFICATION; GENETICS; LUNG TUMOR; METABOLISM; MUTATION; NON SMALL CELL LUNG CANCER; PROCEDURES; PROTO ONCOGENE; THERAPEUTIC USE;

ADENOCARCINOMA; CARCINOMA, NON-SMALL-CELL LUNG; CODON; EXONS; FEMALE; GENE AMPLIFICATION; GENES, ERBB-1; HUMANS; LUNG NEOPLASMS; MUTATION; POINT MUTATION; POLYMERASE CHAIN REACTION; RECEPTOR, EPIDERMAL GROWTH FACTOR; SCORPION VENOMS; SENSITIVITY AND SPECIFICITY; SEQUENCE DELETION;

EID: 46949088190     PISSN: 05295807     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Scagliotti GV, Selvaggi G, Novello S, et al. The biology of epidermal growth factor receptor in lung cancer. Clin Cancer Res, 2004, 10(12 pt 1):4227-4232.
2. Fukuoka M, Yano S, Giaccone G, et al. Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer. J Clin Oncol, 2003, 21 (12): 2237-2246.
3. Kris MG, Natale RB, Herbst RS, et al. Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: randomized trial. JAMA, 2004, 290(16): 2149-2158.
4. Parra HS, Carina R, Latteri F, et al. Analysis of pidermal growth factor receptor expression as a predictive factor for reponse to gefitinib ("Iressa", ZD1839) in non-small cell lung cancer. Br J Cancer, 2004, 91(2):208-212.
5. Paez JG, Janne PA, Lee JC, et al. EGFR mutations in lung cancer; correlation with clinical response to gefitinib therapy. Science, 2004, 304(5676): 1497-1500.
6. Lynch TJ, Bell DW, Sordella R, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med, 2004, 350 (21): 2129-2139.
7. Shigematsu H, Lin L, Takahashi T, et al. Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. J Natl Cancer Inst, 2005, 97 (5): 339-346.
8. Pao W, Miller V, Zakowski M, et al. EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci U S A, 2004, 101(36): 13306-13311.
9. Kosaka T, Yatabe Y, Endoh H, et al. Mutations of the epidermal growth factor receptor gene in lung cancer; biological and clinical implications. Caner Res, 2004, 64 (24): 8919-8923.
10. Sasaki H, Endo K, Takada M, et al. EGFR exon 20 insertion mutation in Japanese lung cancer. Lung Cancer, 2007, 58(3): 324-328.
11. Whitcombe D, Theaker J, Guy SP, et al. Detection of PCR products using self-probing amplicons and fluorescence. Nat Biotechnol, 1999, 17(8): 804-807.
12. Newton CR, Graham A, Heptinstall LE, et al. Analysis of any point mutation in DNA; the amplification refractory mutation system (ARMS). Nucleic Acids Res, 1989, 17 (7):2503-2516.
13. Bates JA, Taylor EA. Scorpion ARMS primers for SNP real-time PCR detection and quantification of Pyrenophora teres. Mol Plant Pathol, 2001, 2(5):275-280.
14. Tomizawa Y, Iijima H, Sunaga N, et al. Clinicopathologic significance of the mutations of the epidermal growth factor receptor gene in patients with non-small cell lung cancer. Clin Cancer Res, 2005, 11 (19 pt 1):6816-6822.
15. Fujino S, Enokibori T, Tezuka N, et al. A comparison of epidermal growth factor receptor levels and other prognostic parameters in non-small cell lung cancer. Eur J Cancer, 1996, 32A (12): 2070-2074.
16. Tokumo M, Toyooka S, Kiura K, et al. The relationship between epidermal growth factor receptor mutations and clinicopathologic features in non-small-cell lung cancers. Clin Cancer Res, 2005, 11(3): 1167-1173.
17. Bell DW, Lynch TJ, Haserlat SM, et al. Epidermal growth factor receptor mutations and gene amplification in non-small-cell lung cancer: molecular analysis of the IDEAL/INTACT gefitinib trials. J Clin Oncol, 2005, 23 (31):8081-8092.
18. Sasaki H, Endo K, Konishi A, et al. EGFR Mutation status in Japanese lung cancer patients; genotyping analysis using Light Cycler. Clin Cancer Res,2005, 11(8):2924-2929.
19. Endo K, Konishi A, Sasaki H, et al. Epidermal growth factor receptor gene mutation in non-small cell lung cancer using highly sensitive and fast TaqMan PCR assay. Lung Cancer, 2005, 50 (3):375-384.
20. Pan Q, Pao W, Ladanyi M. Rapid polymerase chain reaction-based detection of epidermal growth factor receptor gene mutations in lung adenocarcinomas. J Mol Diagn, 2005, 7(3):396-403.
21. Chinese source
22. Kimura H, Kasahara K, Kawaishi M, et al. Detection of epidermal growth factor receptor mutations in serum as a predictor of the response to gefitinib in patients with nonsmall-cell lung cancer. Clin Cancer Res, 2006, 12(13):3915-3921.
23. Horiike A, Kimura H, Nishio K, et al. Detection of epidermal growth factor receptor mutation in transbronchial needle aspirates of non-small cell lung cancer. Chest,2007, 131(6):1628-1634.