Derivatization of β-dicarbonyl compound with 2,4- dinitrophenylhydrazine to enhance mass spectrometric detection: Application in quantitative analysis of houttuynin in human plasma

Journal of Mass Spectrometry

Volumn 43, Issue 6, 2008, Pages 814-824

  Duan, Xiaotao ^b   Zhong, Dafang ^a   Chen, Xiaoyan ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Derivatization; Dinitrophenylhydrazine; Houttuynin; Liquid chromatography tandem mass spectrometry

Indexed keywords

ACETALDEHYDE (CH3CHO); AQUEOUS PHASE; BENZOPHENONE (BZ); CHEMICAL DERIVATIZATION (CHD); DERIVATIZATION OF; DNPH DERIVATIVES; FRAGMENTATION BEHAVIOR; HETEROCYCLIC STRUCTURES; HIGH ACCURACY; HIGH RESOLUTIONS; HUMAN PLASMAS; INTERNAL STANDARD (IS); LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY (LC MS MS); LOWER LIMIT OF QUANTIFICATION (LLOQ); MASS SPECTROMETRIC (MS) DETECTION; MASS-SPECTRAL ANALYSIS; N-HEXANE; PRIMARY REACTION; QUANTITATIVE ANALYSIS; SELECTED REACTION MONITORING (SRM); VOLATILE OILS;

2,4 DINITROPHENYLHYDRAZINE; BENZOPHENONE; CARBONYL DERIVATIVE; HOUTTUYNIA CORDATA EXTRACT;

ACCURACY; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG IDENTIFICATION; DRUG STABILITY; HUMAN; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NORMAL HUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; TANDEM MASS SPECTROMETRY;

ALDEHYDES; CHROMATOGRAPHY, LIQUID; HOUTTUYNIA; HUMANS; PHENYLHYDRAZINES; TANDEM MASS SPECTROMETRY;

EID: 46849119035     PISSN: 10765174     EISSN: 10969888     Source Type: Journal    
DOI: 10.1002/jms.1382     Document Type: Article

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