Interaction of methimazole with I2: X-ray crystal structure of the charge transfer complex methimazole-I2. Implications for the mechanism of action of methimazole-based antithyroid drugs

Journal of Medicinal Chemistry

Volumn 51, Issue 13, 2008, Pages 4050-4053

  Isaia, Francesco ^a   Aragoni, M Carla ^a   Arca, Massimiliano ^a   Demartin, Francesco ^b   Devillanova, Francesco A ^a   Floris, Giovanni ^a   Garau, Alessandra ^a   Hursthouse, Michael B ^c   Lippolis, Vito ^a   Medda, Rosaria ^a   Oppo, Fabio ^a   Pira, Marilena ^a   Verani, Gaetano ^a  

^a UNIVERSITY OF CAGLIARI   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1 METHYLIMIDAZOLE; ANTITHYROID AGENT; BIS(1 METHYLIMIDAZOLE) DISULFIDE; IODINE; PROPYLTHIOURACIL; THIAMAZOLE; DISULFIDE; ENZYME INHIBITOR; ION; LACTOPEROXIDASE;

ANTIOXIDANT ACTIVITY; ARTICLE; CRYSTAL STRUCTURE; DRUG MECHANISM; DRUG SYNTHESIS; IC 50; IODINATION; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; METABOLISM; OXIDATION REDUCTION REACTION; SPECTROPHOTOMETRY; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ANTITHYROID AGENTS; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; DISULFIDES; ENZYME INHIBITORS; IODINE; IONS; LACTOPEROXIDASE; METHIMAZOLE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; SPECTROPHOTOMETRY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 46849117789     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm8001857     Document Type: Article

References (22)

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