Intratympanic gentamicin therapy for control of vertigo in unilateral Menière's disease: A prospective, double-blind, randomized, placebo-controlled trial

Acta Oto-Laryngologica

Volumn 128, Issue 8, 2008, Pages 876-880

  Postema, Rolf J ^a   Kingma, Charlotte M ^a   Wit, Hero P ^a   Albers, Frans W J ^b   Van Der Laan, Bernard F A M ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Aminoglycosides; Aural fullness; Gentamicin; Intratympanic; Meni re's disease

Indexed keywords

GENTAMICIN; PLACEBO;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; HEARING LOSS; HUMAN; MENIERE DISEASE; PRIORITY JOURNAL; PURE TONE AUDIOMETRY; RANDOMIZED CONTROLLED TRIAL; TINNITUS; VERTIGO;

ANTI-BACTERIAL AGENTS; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; EAR, MIDDLE; FEMALE; FOLLOW-UP STUDIES; GENTAMICINS; HUMANS; MALE; MENIERE DISEASE; MIDDLE AGED; PROSPECTIVE STUDIES; TREATMENT OUTCOME; VERTIGO;

EID: 46849116225     PISSN: 00016489     EISSN: 16512553     Source Type: Journal    
DOI: 10.1080/00016480701762458     Document Type: Article

References (8)

1. Schuknecht HF. Ablation therapy in the management of Meniere's disease. Acta Otolaryngol Suppl 1957;132:1-42.
2. Chia SH, Gamst AC, Anderson JP, Harris JP. Intratympanic gentamicin therapy for Meniere's disease: a meta-analysis. Otol Neurotol 2004;25:544-52.
3. Cohen-Kerem R, Kisilevsky V, Einarson TR, Kozer E, Koren G, Rutka JA. Intratympanic gentamicin for Meniere's disease: a meta-analysis. Laryngoscope 2004;114:2085-91.
4. Stokroos R, Kingma H. Selective vestibular ablation by intratympanic gentamicin in patients with unilateral active Ménière's disease: a prospective, double-blind, placebo-controlled, randomized clinical trial. Acta Otolaryngol (Stockh) 2004;124:172-5.
5. AAO-HNS. Committee on hearing and equilibrium guidelines for the diagnosis and evaluation of therapy in Meniere's disease. Otolaryngol Head Neck Surg 1995;113:181-5.
6. Mateijsen DJM. Definition Menière Groningen, a rational approach to Menière's disease [Thesis]. Groningen, The Netherlands: Rijksuniversiteit, 2001.
7. Abou-Halawa AS, Poe DS. Efficacy of increased gentamicin concentration for intratympanic injection therapy in Ménière's disease. Otol Neurotol 2002;23:494-503.
8. Zucca G, Botta L, Mira E, Manfrin M, Poletti A, Buizza A, et al. Effects of hydrostatic pressure on sensory discharge in frog semicircular canals. Acta Otolaryngol (Stockh) 1991;111:820-6.