Effect of a combination of medium chain triglycerides, linoleic acid, soy lecithin and vitamins A and E on wound healing in rats

Acta Cirurgica Brasileira

Volumn 23, Issue 3, 2008, Pages 262-269

  Magalhães, Maria Sonia Felício ^a   Fechine, Francisco Vagnaldo ^a   De Macedo, Rafael Nogueira ^a   Monteiro, Diego Levi Silveira ^a   Oliveira, Cecília Carvalho ^a   Brito, Gerly Anne De Castro ^a   De Moraes, Maria Elisabate Amaral ^a   De Moraes, Manoel Odorico ^a,b  

^a FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^b UFC ^*  (Brazil)

Author keywords

Linoleic acid; Rats; Triglycerides; Wound healing

Indexed keywords

ALPHA TOCOPHEROL; CLOSTEBOL; DECANOIC ACID; HEXANOIC ACID; LAURIC ACID; LINOLEIC ACID; MEDIUM CHAIN TRIACYLGLYCEROL; NEOMYCIN; OCTANOIC ACID; PHOSPHATIDYLCHOLINE; RETINOL; SODIUM CHLORIDE; SOY LECITHIN; WOUND HEALING PROMOTING AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; MALE; NONHUMAN; RAT; SKIN FLAP; SKIN TEST; SKIN ULCER; SKINFOLD THICKNESS; STATISTICAL SIGNIFICANCE; TREATMENT OUTCOME; ULCER HEALING; WOUND HEALING;

ANIMALS; DISEASE MODELS, ANIMAL; DRUG COMBINATIONS; DRUG EVALUATION, PRECLINICAL; LINOLEIC ACID; MALE; RATS; RATS, WISTAR; SKIN ULCER; SOYBEAN PROTEINS; TIME FACTORS; TRIGLYCERIDES; VITAMIN A; VITAMIN E; VITAMINS; WOUND HEALING;

EID: 46849108704     PISSN: 01028650     EISSN: 16782674     Source Type: Journal    
DOI: 10.1590/S0102-86502008000300009     Document Type: Article

References (19)

1. Carrel A. The treatment of wounds. JAMA. 1910;55:2148-50.
2. Ortonne JP, Clévy JP. Physiology of cutaneous cicatrization. Rev Prat. 1994; 44(13):1733-7.
3. Araújo CFR, Souza Fo ZA, Greca FH, Guerreiro MHCPM, Leite AL, Mansur AE C, Kantor DC, Nassif AE. Effects of Agarol® and Trigliceril® on cutaneous wound healing: experimental study in rats. Acta Cir Bras. 1998;13(4):232-7.
4. Banda MJ, Knighton DR, Hunt TK, Werb Z. Isolation of a nonmitogenic angiogenesis factor from wound fluid. Proc Nat Acad Sci. 1982;79:7773-7.
5. Mori, R.; Kondo, T.; Nishiie, T.; Ohshima, T.; Asano, M. Impairment of skin wound healing in β-1,4-galactosyltransferase-deficient mice with reduced leukocyte recruitment. Am J Pathol. 2004;164(4):1303-14.
6. D'Agostini D. Obtenção de lipídíos estruturados por intereterificação de triacilglicerois de cadeia média e longa [Tese de Doutorado]. Universidade de São Paulo, Faculdade de Ciências Farmacêuticas; 2001.
7. Hatanaka E, Curi R. Fatty acids and wound healing: a review. RevRv Bras Farmacol. 2007;88(2):53-8.
8. Cardoso CRB, Souza MA, Ferro EAV, Favoreto S, Pena JDO. Influence of topical administration of n-3 and n-6 essential and n-9 nonessential fatty acids on the healing of cutaneous wounds. Wound Rep Reg. 2004;12:235-43.
9. De Nardi AB, Rodaski S, Sousa RS, Baudi DLK, Castro JHT. Secondary cicatrization in dermoepidermal wounds treated with essential fatty acids, vitamins A and E, soy lecithin and polynylpyrrolidone-iodine in dogs. Arc Vet Sci. 2004;9(1):1-16
10. Ehrlich HP , Hunt TK. Effects of cortisone and vitamin A on wound healing. Ann Surg. 1968;167:324-8.
11. Greenway DLA & Dyke KGH. Mechanism of the inhibitory action of linoleic acid on the growth of Staphylococcus aureus. J Gen Microbiol. 1979;115:233-45.
12. Moch D, Sheva T, Heihn H, Schimidt D, Buntroc P. The linoleic acid metabolite 2 Ds-hidroxi-10, 12 (E-Z): octadecadienoic acid is a strong, proinflammatory mediator in a experimental would healing model of the rat. Biom Biochem Acta. 1990;49:201-7.
13. Teixeira VPA, Pereira SAL, Rodrigues DBR, Lino RSJ. Princípios básicos e aplicações da morfometria. Disponível em: http://www.uftm.edu.br/instpub/fmtm/patge/morfometria01.htm. Acesso em: 17 jul.2007.
14. Mandarin-de-Lacerda, CA. Stereological tools in biomedical reserarch. An Acad Bras Cienc. 2003;75(4):469-86.
15. Marques SR, Peixoto CA, Messias JB, Albuqurque AR, Silva Jr VA. The effects of topical application of sunflower-seed oil on open wound healing in lambs. Acta Cir Bras. 2004;19(3):196-209.
16. Martins NLP, Malafaia O, Ribas-Filho JM, Heibel M, Baldez RN, Vasconcelos PRL, Moreira H, Mazza M, Nassif PAN, Wallbach TZ. Healing process in cutaneous surgical wounds in rats under the influence of Orbignya phalerata aqueous extract. Acta Cir Bras. 2006;21(supl 3):66-75.
17. Mandelbaum SH, Di Santis EP, Mandelbaum MHSA. Cicatrization: current and auxiliary resources-Part 1. An Bras Dermatol. 2003;78(4):393-410.
18. Rodrigues KL, Cardoso CC, Caputo LR, Carvalho JCT, Fiorini JE, Schneedorf JM. Cicatrizing and antimicrobial properties of an ozonised oil from sunflower seeds. Inflammopharmacology. 2004;12(3):261-70.
19. Sakuma CH, Matera JM, Valente NS. Clinical study of skin flap application during oncologic surgery in dog. Bras J Vet Res Anim Sci. 2003;40 Suppl:32-7.