Cerebral metabolic dysfunction in patients with dementia with Lewy bodies and visual hallucinations

Dementia and Geriatric Cognitive Disorders

Volumn 25, Issue 6, 2008, Pages 531-538

  Perneczky, Robert ^a   Drzezga, Alexander ^a   Boecker, Henning ^a,b   Förstl, Hans ^a   Kurz, Alexander ^a   Häussermann, Peter ^a,c  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF BONN   (Germany)

^c Center for Integrative Psychiatry   (Germany)

Author keywords

Dementia with Lewy bodies; Metabolic dysfunction; Psychosis; Visual hallucinations

Indexed keywords

FLUORODEOXYGLUCOSE F 18;

ADULT; AGED; ARTICLE; BRAIN METABOLISM; BRAIN SCINTIANGIOGRAPHY; CLINICAL ARTICLE; CONTROLLED STUDY; DIFFUSE LEWY BODY DISEASE; FEMALE; FRONTAL CORTEX; HUMAN; MALE; METABOLIC DISORDER; OCCIPITAL CORTEX; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PSYCHOSIS; TEMPORAL CORTEX; VISUAL HALLUCINATION;

AGED; FEMALE; FLUORODEOXYGLUCOSE F18; FRONTAL LOBE; HALLUCINATIONS; HUMANS; LEWY BODY DISEASE; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; TEMPORAL LOBE; VISUAL CORTEX;

EID: 46849085770     PISSN: 14208008     EISSN: None     Source Type: Journal    
DOI: 10.1159/000132084     Document Type: Article

References (45)

1. Boecker H, Ceballos-Baumann AO, Volk D, Conrad B, Förstl H, Häussermann P: Metabolic alterations in patients with Parkinson disease and visual hallucinations. Arch Neurol 2007;64:984-988.
2. Barnes J, David AS: Visual hallucinations in Parkinson's disease: a review and phenomenological survey. J Neurol Neurosurg Psychiatry 2001;70:727-733.
3. Takahashi N, Kawamura M: Simple partial seizure consisting of complex visual hallucinations due to left temporo-occipital lesion (in Japanese). Rinsho Shinkeigaku 1996;36:665-669.
4. Rousseaux M, Debrock D, Cabaret M, Steinling M: Visual hallucinations with written words in a case of left parietotemporal lesion. J Neurol Neurosurg Psychiatry 1994;57:1268-1271.
5. McKeith IG, Galasko D, Kosaka K, Perry EK, Dickson DW, Hansen LA, Salmon DP, Lowe J, Mirra SS, Byrne EJ, Lennox G, Quinn NP, Edwardson JA, Ince PG, Bergeron C, Burns A, Miller BL, Lovestone S, Collerton D, Jansen ENH, Ballard C, de Vos RAI, Wilcock GK, Jellinger KA, Perry RH: Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB International Workshop. Neurology 1996;47:1113-1124.
6. Higuchi M, Tashiro M, Arai H, Okamura N, Hara S, Higuchi S, Itoh M, Shin RW, Trojanowski JQ, Sasaki H: Glucose hypometabolism and neuropathological correlates in brains of dementia with Lewy bodies. Exp Neurol 2000;162:247-256.
7. Harding AJ, Broe GA, Halliday GM: Visual hallucinations in Lewy body disease relate to Lewy bodies in the temporal lobe. Brain 2002;125:391-403.
8. Lippa CF, Duda JE, Grossman M, Hurtig HI, Aarsland D, Boeve BF, Brooks DJ, Dickson DW, Dubois B, Emre M, Fahn S, Farmer JM, Galasko D, Galvin JE, Goetz CG, Growdon JH, Gwinn-Hardy KA, Hardy J, Heutink P, Iwatsubo T, Kosaka K, Lee VM, Leverenz JB, Masliah E, McKeith IG, Nussbaum RL, Olanow CW, Ravina BM, Singleton AB, Tanner CM, Trojanowski JQ, Wszolek ZK: DLB and PDD boundary issues: diagnosis, treatment, molecular pathology, and biomarkers. Neurology 2007;68:812-819.
9. Morris JC, Mohs RC, Rogers H, Fillenbaum G, Heyman A: Consortium to establish a registry for Alzheimer's disease (CERAD) clinical and neuropsychological assessment of Alzheimer's disease. Psychopharmacol Bull 1988;24:641-652.
10. Thalmann B, Monsch AU: CERAD: The Consortium to Establish a Registry for Alzheimer's Disease (Neuropsychologische Testbatterie). Basel, Memory Clinic Basel, 1997.
11. Folstein MF, Folstein SE, McHugh PR: 'Mini-Mental State': a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189-198.
12. Chandler MJ, Lacritz LH, Hynan LS, Barnard HD, Allen G, Deschner M, Weiner MF, Cullum CM: A total score for the CERAD neuropsychological battery. Neurology 2005;65:102-106.
13. Cummings JL, Mega M, Gray K, Rosenberg-Thompson S, Carusi DA, Gornbein J: The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia. Neurology 1994;44:2308-2314.
14. Fahn S, Elton R, Members of the UPDRS development committee: Unified Parkinson's Rating Scale; in Fahn S, Marsden C, Calne D, Goldstein M (eds): Recent Developments in Parkinson's Disease. Florhan Park, MacMillan Healthcare Information, 1987.
15. McKhann G, Folstein M, Katzman R, Price D, Stadlan EM: Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984;34:939-944.
16. Neary D, Snowden JS, Gustafson L, Passant U, Stuss D, Black S, Freedman M, Kertesz A, Robert PH, Albert M, Boone K, Miller BL, Cummings J, Benson DF: Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria. Neurology 1998;51:1546-1554.
17. Hughes AJ, Daniel SE, Kilford L, Lees AJ: Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 1992;55:181-184.
18. Emre M, Aarsland D, Brown R, Burn DJ, Duyckaerts C, Mizuno Y, Broe GA, Cummings J, Dickson DW, Gauthier S, Goldman J, Goetz C, Korczyn A, Lees A, Levy R, Litvan I, McKeith I, Olanow W, Poewe W, Quinn N, Sampaio C, Tolosa E, Dubois B: Clinical diagnostic criteria for dementia associated with Parkinson's disease. Mov Disord 2007;22:1689-1707.
19. Drzezga A, Riemenschneider M, Strassner B, Grimmer T, Peller M, Knoll A, Wagenpfeil S, Minoshima S, Schwaiger M, Kurz A: Cerebral glucose metabolism in patients with AD and different APOE genotypes. Neurology 2005;64:102-107.
20. Laws SM, Perneczky R, Drzezga A, Diehl-Schmid J, Ibach B, Bauml J, Eisele T, Förstl H, Kurz A, Riemenschneider M: Association of the tau haplotype H2 with age at onset and functional alterations of glucose utilization in frontotemporal dementia. Am J Psychiatry 2007;164:1577-1584.
21. Ishii K, Soma T, Kono AK, Sofue K, Miyamoto N, Yoshikawa T, Mori E, Murase K: Comparison of regional brain volume and glucose metabolism between patients with mild dementia with Lewy bodies and those with mild Alzheimer's disease. J Nucl Med 2007;48:704-711.
22. Talairach J, Tournoux P: Co-Planar Stereotaxic Atlas of the Human Brain: 3-Dimensional Proportional System - An Approach to Cerebral Imaging. New York, Thieme Medical Publishers, 1988.
23. Perneczky R, Wagenpfeil S, Komossa K, Grimmer T, Diehl J, Kurz A: Mapping scores onto stages: Mini-Mental State Examination and clinical dementia rating. Am J Geriatr Psychiatry 2006;14:139-144.
24. Mosimann UP, Rowan EN, Partington CE, Collerton D, Littlewood E, O'Brien JT, Burn DJ, McKeith IG: Characteristics of visual hallucinations in Parkinson disease dementia and dementia with Lewy bodies. Am J Geriatr Psychiatry 2006;14:153-160.
25. Ungerleider LG, Haxby JV: 'What' and 'where' in the human brain. Curr Opin Neurobiol 1994;4:157-165.
26. Matsui H, Nishinaka K, Oda M, Hara N, Komatsu K, Kubori T, Udaka F: Hypoperfusion of the visual pathway in parkinsonian patients with visual hallucinations. Mov Disord 2006;21:2140-2144.
27. Nagano-Saito A, Washimi Y, Arahata Y, Iwai K, Kawatsu S, Ito K, Nakamura A, Abe Y, Yamada T, Kato T, Kachi T: Visual hallucination in Parkinson's disease with FDG PET. Mov Disord 2004;19:801-806.
28. Okada K, Suyama N, Oguro H, Yamaguchi S, Kobayashi S: Medication-induced hallucination and cerebral blood flow in Parkinson's disease. J Neurol 1999;246:365-368.
29. Oishi N, Udaka F, Kameyama M, Sawamoto N, Hashikawa K, Fukuyama H: Regional cerebral blood flow in Parkinson disease with nonpsychotic visual hallucinations. Neurology 2005;65:1708-1715.
30. Lance JW: Simple formed hallucinations confined to the area of a specific visual field defect. Brain 1976;99:719-734.
31. Zoldan J, Friedberg G, Weizman A, Melamed E: Ondansetron: a 5-HT3 antagonist for visual hallucinations and paranoid delusional disorder associated with chronic L-dopa therapy in advanced Parkinson's disease. Adv Neurol 1996;69:541-544.
32. Goetz CG, Pappert EJ, Blasucci LM, Stebbins GT, Ling ZD, Nora MV, Carvey PM: Intravenous levodopa in hallucinating Parkinson's disease patients: high-dose challenge does not precipitate hallucinations. Neurology 1998;50:515-517.
33. Perry EK, Smith CJ, Court JA, Perry RH: Cholinergic nicotinic and muscarinic receptors in dementia of Alzheimer, Parkinson and Lewy body types. J Neural Transm Park Dis Dement Sect 1990;2:149-158.
34. Perry RH, Irving D, Blessed G, Perry EK, Smith CJ, Fairbairn AF: Dementia in old age: identification of a clinically and pathologically distinct disease category. Adv Neurol 1990;51:41-46.
35. O'Brien JT, Firbank MJ, Mosimann UP, Burn DJ, McKeith IG: Change in perfusion, hallucinations and fluctuations in consciousness in dementia with Lewy bodies. Psychiatry Res 2005;139:79-88.
36. Imamura T, Ishii K, Hirono N, Hashimoto M, Tanimukai S, Kazuai H, Hanihara T, Sasaki M, Mori E: Visual hallucinations and regional cerebral metabolism in dementia with Lewy bodies (DLB). Neuroreport 1999;10:1903-1907.
37. Mori T, Ikeda M, Fukuhara R, Nestor PJ, Tanabe H: Correlation of visual hallucinations with occipital RCBF changes by donepezil in DLB. Neurology 2006;66:935-937.
38. Collerton D, Perry E, McKeith I: Why people see things that are not there: a novel perception and attention deficit model for recurrent complex visual hallucinations. Behav Brain Sci 2005;28:737-757, discussion 757-794.
39. Geser F, Wenning GK, Poewe W, McKeith I: How to diagnose dementia with Lewy bodies: state of the art. Mov Disord 2005;20(suppl 12):S11-S20.
40. Tiraboschi P, Salmon DP, Hansen LA, Hofstetter RC, Thal LJ, Corey-Bloom J: What best differentiates Lewy body from Alzheimer's disease in early-stage dementia? Brain 2006;129:729-735.
41. Perneczky R, Mösch D, Neumann M, Kretzschmar H, Müller U, Busch R, Förstl H, Kurz A: The Alzheimer variant of Lewy body disease: a pathologically confirmed casecontrol study. Dement Geriatr Cogn Disord 2005;20:89-94.
42. Merdes AR, Hansen LA, Jeste DV, Galasko D, Hofstetter CR, Ho GJ, Thal LJ, Corey-Bloom J: Influence of Alzheimer pathology on clinical diagnostic accuracy in dementia with Lewy bodies. Neurology 2003;60:1586-1590.
43. Del Ser T, Hachinski V, Merskey H, Munoz DG: Clinical and pathologic features of two groups of patients with dementia with Lewy bodies: effect of coexisting Alzheimer-type lesion load. Alzheimer Dis Assoc Disord 2001;15:31-44.
44. Mosimann UP, Collerton D, Dudley R, Meyer TD, Graham G, Dean JL, Bearn D, Killen A, Dickinson L, Clarke MP, McKeith IG: A semi-structured interview to assess visual hallucinations in older people. Int J Geriatr Psychiatry 2008, E-pub ahead of print.
45. Walker MP, Ayre GA, Cummings JL, Wesnes K, McKeith IG, O'Brien JT, Ballard CG: Quantifying fluctuation in dementia with Lewy bodies, Alzheimer's disease, and vascular dementia. Neurology 2000;54:1616-1625.