Estimating intracellular lithium in brain in vivo by localized 7Li magnetic resonance spectroscopy

Magnetic Resonance in Medicine

Volumn 60, Issue 1, 2008, Pages 21-26

  Komoroski, Richard A ^a,b   Pearce, John M ^a,b  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Bipolar disorder; Lithium; Manic depressive illness; Spin relaxation; Spin spin relaxation time

Indexed keywords

LITHIUM; MAGNETIC RESONANCE; MAGNETIC RESONANCE SPECTROSCOPY;

BIPOLAR DISORDER; INDIVIDUAL COMPONENTS; LINEAR APPROXIMATIONS; MANIC-DEPRESSIVE ILLNESS; MECHANISM OF ACTION; SPIN RELAXATION; SPIN-SPIN RELAXATION TIME; TRANSVERSE RELAXATION;

LITHIUM METALLOGRAPHY;

LITHIUM 7; LITHIUM CHLORIDE; TRACER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIPOLAR DISORDER; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BRAIN LEVEL; ELECTRON SPIN RESONANCE; IN VIVO STUDY; ISOTOPE LABELING; MALE; MANIC DEPRESSIVE PSYCHOSIS; MATHEMATICAL COMPUTING; NON INVASIVE MEASUREMENT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RAT; RELAXATION TIME;

EID: 46849085409     PISSN: 07403194     EISSN: 15222594     Source Type: Journal    
DOI: 10.1002/mrm.21613     Document Type: Article

References (40)

1. Lenox RH, Hahn C-G. Overview of the mechanism of action of lithium in the brain: fifty-year update. J Clin Psychiatry 2000;61(Suppl 9):5-15.
2. Manji HK, Potter WZ, Lenox RH. Signal transduction pathways. Molecular targets for lithium's actions. Arch Gen Psychiatry 1995;52:531-543.
3. Birch NJ, Gallicchio VS, Becker RW, editors. Lithium: 50 years of psychopharmacology: new perspectives in biomedical and clinical research. Cheshire, CT: Weidner Publishing Group; 1999. 257 p.
4. + in the treatment of bipolar disorder. Trends Neurosci 1995;18:343-349.
5. Phiel CJ, Klein PS. Molecular targets of lithium action. Ann Rev Pharmacol Toxicol 2001;41:789-813.
6. Harwood AJ, Agam G. Search for a common mechanism of mood stabilizers. Biochem Pharmacol 2003;66:179-189.
7. Waldmeier PC. Mechanisms of action of lithium in affective disorders: a status report. Pharmacol Toxicol 1990;66(Suppl 3):121-132.
8. El-Mallakh RS, Wyatt RJ. The Na,K-ATPase hypothesis for bipolar illness. Biol Psychiatry 1995;37:235-244.
9. Lenox RH, Wang L. Molecular basis of lithium action: integration of lithium-responsive signaling and gene expression networks. Mol Psychiatry 2003;8:135-144.
10. Salinas PC, Hall AC. Lithium and synaptic plasticity. Bipolar Disord 1999;2:87-90.
11. Brunello N, Tascedda F. Cellular mechanisms and second messengers: relevance to the psychopharmacology of bipolar disorders. Int J Neuropsychopharmacol 2003;6:181-189.
12. Birch NJ. Lithium ions have limited intracellular access: implications for cell regulation and pharmacology. J Trace Microprobe Tech 1994;12:1-16.
13. 7Li NMR in biomedicine. Magn Reson Imaging 2000;18:103-116.
14. 7Li magnetic resonance spectroscopy (MRS): a literature review. Eur Neuropsychopharmacol 2000;10:151-158.
15. 7Li NMR. NMR Biomed 2005;18:67-73.
16. Springer CS. Measurement of metal cation compartmentalization in tissue by high-resolution metal cation NMR, Ann Rev Biophys Biophys Chem 1987;16:375-399.
17. 5- infusion. J Magn Reson Imaging 1992;2:385-391.
18. 5- as an NMR shift reagent and extracellular marker. J Appl Physiol 1998;85:1806-1812.
19. 7Li NMR studies on shift reagent infused rats. J Environ Sci Health A Tox Hazard Subst Environ Eng 1999;34:1839-1848.
20. 7Li magnetic resonance spectroscopy and spin relaxation in rat brain in vivo. Magn Reson Med 2004;52:164-168.
21. 7Li magnetic resonance spectroscopy: in vivo brain and serum concentrations in the rat. Magn Reson Med 2004;52:1087-1092.
22. Akitt JW. The alkali and alkaline earth metals. In: Mason J, editor. Multinuclear NMR. New York: Plenum; 1987. p 189-220.
23. 7Li NMR study of visibility, spin relaxation, and transport in normal human erythrocytes. Magn Reson Med 1991;20:240-252.
24. 2+ competition in cells: implications for bipolar disorder. Biochem Pharmacol 2003;66:1915-1924.
25. 2+ competition in bovine chromaffin cells. Biochim Biophys Acta 2004;1691:79-90.
26. a1. Biochim Biophys Acta 1983;763:35-40.
27. Burstein D, Fossel ET. Intracellular sodium and lithium NMR relaxation times in the perfused frog heart. Magn Reson Med 1987;4:261-273.
28. Stobbe R, Beaulieu C. In vivo sodium magnetic resonance imaging of the human brain using soft inversion recovery fluid attenuation. Magn Reson Med 2005;54:1305-1310.
29. Komoroski RA, Pearce JM. Estimating intracellular lithium in brain in vivo by lithium-7 MRS. In: Proceedings of the 14th Annual Meeting of ISMRM, Seattle, WA, USA, 2006 (Abstract 953).
30. Shargel L, Wu-Pong S, Yu ABC. Applied biopharmaceutics and pharmacokinetics. 5th edition. New York: McGraw-Hill; 2005. 892 p.
31. Duong TQ, Sehy JV, Yablonskiy DA, Snider BJ, Ackerman JJH, Neil JJ. Extracellular apparent diffusion in rat brain. Magn Reson Med 2001;45:801-810.
32. Goodman JA, Kroenke CD, Bretthorst GL, Ackerman JJH, Neil JJ. Sodium ion apparent diffusion coefficient in living rat brain. Magn Reson Med 2005;53:1040-1045.
33. Silva MD, Omae T, Helmer KG, Li F, Fisher M, Sotak CH. Separating changes in the intra- and extracellular water apparent diffusion coefficient following focal cerebral ischemia in the rat brain. Magn Reson Med 2002;48:826-837.
34. Bendel P, Eilam R. Quantitation of ventricular size in normal and spontaneously hypertensive rats by magnetic resonance imaging. Brain Res 1992;574:224-228.
35. Pfefferbaum A, Adalsteinsson E, Sullivan EV. In vivo structural imaging of the rat brain with a 3-T clinical human scanner. J Magn Reson Imaging 2004;20:779-785.
36. Wraae O. The pharmacokinetics of lithium in the brain, cerebrospinal fluid and serum of the rat. Br J Pharmacol 1978;64:273-279.
37. 23Na in normal human erythrocytes. Magn Reson Med 1992;27:1-12.
38. Ramaprasad S. Magnetic resonance spectroscopic imaging studies of lithium. Progress in Nuclear Magnetic Resonance Spectroscopy 2005;47:111-121.
39. 7Li NMR imaging. J Magn Reson 1998;133:98-103.
40. Istratov AA, Vyvenko OF. Exponential analysis in physical phenomena. Rev Sci Instr 1999;70:1233-1257.