Unidirectional polymerization leading to homochirality in the RNA world

International Journal of Astrobiology

Volumn 4, Issue 3-4, 2005, Pages 233-239

  Nilsson, M ^a,b   Brandenburg, A ^a   Andersen, A C ^a   Hofner S ^a,c  

^a NORDITA   (Denmark)

^b CHALMERS UNIVERSITY OF TECHNOLOGY   (Sweden)

^c UPPSALA UNIVERSITY   (Sweden)

Author keywords

enantiomeric cross inhibition; origin of homochirality; RNA and DNA polymerization

Indexed keywords

EID: 46749153114     PISSN: 14735504     EISSN: 14753006     Source Type: Journal    
DOI: 10.1017/S1473550405002752     Document Type: Article

References (40)

1. Bada, J.L. (1995). Origins of homochirality. Nature 374, 594–595.
2. Bailey, J. (2001). Astronomical sources of circularly polarized light and the origin of homochirality. Orig. Life Evol. Biosph. 31, 167–183.
3. Bailey, J., Chrysostomou, A., Hough, J.H., Gledhill, T.M., McCall, A., Clark, S., Menard, F. & Tamura, M. (1998). Circular polarization in star forming regions: implications for biomolecular homochirality. Science 281, 672–674.
4. Blackmond, D.G. (2004). Asymmetric autocatalysis and its implications for the origin of homochirality. Proc. Natl. Acad. Sci. 101, 5732–5736.
5. Blackmond, D.G. (2005). Reaction progress kinetic analysis: a powerful methodology for mechanistic studies of complex catalytic reactions. Ang. Chem. Int. Ed. 44, 4302–4320.
6. Blackmond, D.G., McMillan, C.R., Ramdeehul, S., Schorm, A. & Brown, J.M.(2001). Origins of asymmetric amplification in autocatalytic alkylzinc additions. J. Am. Chem. Soc. 123, 10103–10104.
7. Brandenburg, A. & Multamaki, T. (2004). How long can left and right handed life forms coexist? Int. J. Astrobiol. 3, 209–219.
8. Brandenburg, A., Andersen, A.C., Hofner, S. & Nilsson, M. (2005a). Homochiral growth through enantiomeric cross-inhibition. Orig. Life Evol. Biosph. 35, 225–242.
9. Brandenburg, A., Andersen, A.C. & Nilsson, M. (2005b). Dissociation in a polymerization model of homochirality. Orig. Life Evol. Biosph. 35, 507–521.
10. Buono, F.G. & Blackmond, D.G. (2003). Kinetic evidence for a tetrameric transition state in the asymmetric autocatalytic alkylation of pyrimidyl aldehydes. J. Am. Chem. Soc. 125, 8978–8979.
11. Davies, P.C.W. & Lineweaver, C.H. (2005). Finding a second sample of life on Earth. Astrobiol. 5, 154–163.
12. Deamer, D., Dworkin, J.P., Sandford, S.A., Bernstein, M.P. & Allamandola, L.J. (2002). The first cell membranes. Astrobiol. 4, 371–381.
13. Frank, F.C. (1953). On spontaneous asymmetric synthesis. Biochim. Biophys. Acta 11, 459–464.
14. Gilbert, W. (1986). Origin of life - the RNA world. Nature 319, 618.
15. Joyce, G.F., Visser, G.M., van Boeckel, C.A.A., van Boom, J.H., Orgel, L.E. & Westrenen, J. (1984). Chiral selection in poly(C)-directed synthesis of oligo(G). Nature 310, 602–603.
16. Hegstrom, R.A. (1984). Parity nonconservation and the origin of biological chirality - theoretical calculations. Orig. Life 14, 405–414.
17. Kitamura, M., Suga, S., Oka, H. & Noyori, R. (1998). Quantitative analysis of the chiral amplification in the amino alcohol-promoted asymmetric alkylation of aldehydes with dialkylzincs. J. Am. Chem. Soc. 120, 9800–9809.
18. Kozlov, I.A., Pitsch, S. & Orgel, L.E. (1998). Oligomerization of activated D- and L-guanosine mononucleotides on templates containing D- and L-deoxycytidylate residues. Proc. Natl. Acad. Sci. 95, 13448–13452.
19. Mathew, S.P., Iwamura, H. & Blackmond, D.G. (2004). Amplification of enantiomeric excess in a proline-mediated reaction. Ang. Chem. Int. Ed. 43, 3317–3331.
20. Mislow, K. (2003). Absolute asymmetric synthesis: a commentary. Collect. Czech. Chem. Commun. 68, 849–864.
21. Monnard, P.-A. & Deamer, D.W. (2001). Nutrient uptake by protocells: a liposome model system. Orig. Life Evol. Biosph. 31, 147–155.
22. Nelson, K.E., Levy, M. & Miller, S.L. (2000). Peptide nucleic acids rather than RNA may have been the first genetic molecule. Proc. Nat. Acad. Sci. U.S.A. 97, 3868–3871.
23. Plasson, R., Bersini, H. & Commeyras, A. (2004). Recycling Frank: spontaneous emergence of homochirality in noncatalytic systems. Proc. Natl. Acad. Sci. 101, 16733–16738.
24. Pooga, M., Land, T., Bartfai, T. & Langel, U. (2001). PNA oligomers as tools for specific modulation of gene expression. Biomol. Eng. 17, 183–192.
25. Rasmussen, S., Chen, L., Nilsson, M. & Abe, S. (2003). Bridging nonliving and living matter. Artif. Life 9, 269–316.
26. Ray, A. & Norden, B. (2000). Peptide nucleic acid (PNA): its medical and biotechnical applications and promise for the future. FASEB J. 14, 1041–1060.
27. Rikken, G.L.J.A. & Raupach, E. (2000). Enantioselective magnetochiral photochemistry. Nature 405, 932–935.
28. Rubenstein, E., Bonner, W.A., Noyes, H.P. & Brown, G.S. (1983). Super-novae and life. Nature 306, 118–118.
29. Sandars, P.G.H. (2003). A toy model for the generation of homochirality during polymerization. Orig. Life Evol. Biosph. 33, 575–587.
30. Saito, Y. & Hyuga, H. (2004a). Complete homochirality induced by the nonlinear autocatalysis and recycling. J. Phys. Soc. Jap. 73, 33–35. (SH)
31. Saito, Y. & Hyuga, H. (2004b). Homochirality proliferation in space. J. Phys. Soc. Jap. 73, 1685–1688.
32. Sato, I., Urabe, H., Ishiguro, S., Shibata, T. & Soai, K. (2003). Amplification of chirality from extremely low to greater than 99.5% ee by asymmetric autocatalysis. Angew. Chem. Int. Ed. 42, 315–317.
33. Schmidt, J.G., Nielsen, P.E. & Orgel, L.E. (1997). Enantiomeric cross-inhibition in the synthesis of oligonucleotides on a nonchiral template. J. Am. Chem. Soc. 119, 1494–1495.
34. Segré, D., Ben-Eli, D., Deamer, D.W. & Lancet, D. (2001). The lipid world. Orig. Life Evol. Biosph. 31, 119–145.
35. Soai, K., Shibata, T., Morioka, H. & Choji, K. (1995). Asymmetric autocatalysis and amplification of enantiomeric excess of a chiral molecule. Nature 378, 767–768.
36. Strong, W.M. (1898). Stereochemistry and vitalism. Nature 59, 53–54.
37. Thiemann, W. (1984). Speculations and facts on the possible inductions of chirality through earth magnetic field. Orig. Life Evol. Biosph. 14, 421–426.
38. Turner, P.C., McLennan, A.G., Bates, A.D. & White, M.R.H. (2000). Molecular biology. BIOS Scientific Publishers, Taylor & Francis, London.
39. Wattis, J.A.D. & Coveney, P.V. (2005). Symmetry-breaking in chiral polymerization. Orig. Life Evol. Biosph. 35, 243–273.
40. Woese, C. (1967). The Genetic Code. Harper and Row, New York.