Cellular Ti-6Al-4V structures with interconnected macro porosity for bone implants fabricated by selective electron beam melting

Acta Biomaterialia

Volumn 4, Issue 5, 2008, Pages 1536-1544

  Heinl, Peter ^a   Müller, Lenka ^a   Körner, Carolin ^a   Singer, Robert F ^a   Müller, Frank A ^a,b  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Bioactivity; Porous structures; Selective electron beam melting; Surface modification; Titanium alloys

Indexed keywords

ALUMINUM ALLOYS; CHEMICAL MODIFICATION; CHLORINE COMPOUNDS; COMPRESSIVE STRENGTH; COMPUTERIZED TOMOGRAPHY; ELECTRON BEAM MELTING; ELECTRON BEAMS; FABRICATION; PHOSPHATE MINERALS; PORE SIZE; SODIUM HYDROXIDE; TERNARY ALLOYS; TITANIUM ALLOYS;

BONE IMPLANT; CELLULARS; MACRO-POROSITY; MICRO COMPUTER TOMOGRAPHY (ΜCT); ORTHOPAEDIC APPLICATIONS; POROUS STRUCTURES; SELECTIVE ELECTRON BEAM MELTING; SURFACE-MODIFICATION; THREE-DIMENSIONAL STRUCTURE; TITANIUM (ALLOYS);

SURFACE TREATMENT;

APATITE; CHLORIDE; SODIUM HYDROXIDE; TITANIUM;

ARTICLE; BIOENGINEERING; BODY FLUID; CHEMICAL MODIFICATION; CHEMICAL STRUCTURE; COMPRESSIVE STRENGTH; CONTROLLED STUDY; IMPLANT; IN VITRO STUDY; MECHANICAL STRESS; MICRO-COMPUTED TOMOGRAPHY; MOLECULAR STABILITY; ORTHOPEDIC EQUIPMENT; POROSITY; PRIORITY JOURNAL; SELECTIVE ELECTRON BEAM MELTING; SIMULATION; SURFACE PROPERTY; THREE DIMENSIONAL IMAGING; TISSUE GROWTH; VASCULARIZATION; YOUNG MODULUS;

EID: 46749127071     PISSN: 17427061     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.actbio.2008.03.013     Document Type: Article

References (31)

1. Okazaki Y., Rao S., Ito Y., and Tateishi T. Corrosion resistance, mechanical properties and cytocompatibility of new Ti alloys without Al and V. Biomaterials 19 (1998) 1197-1215
2. Okazaki Y., Nishimura E., Nakada E., and Kobayashi K. Surface analysis of Ti-15Zr-4Nb-4Ta alloy after implantation in rat tibia. Biomaterials 22 (2001) 599-607
3. Eisenbarth E., Velten D., Müller M., Thull R., and Breme J. Biocompatibility of β-stabilizing elements of titanium alloys. Biomaterials 25 (2004) 5705-5713
4. Moyen B.J., Lahey Jr. P.J., Weinberg E.H., and Harris W.H. Effects on intact femora of dogs of the application and removal of metal plates. A metabolic and structural study comparing stiffer and more flexible plates. J Bone Joint Surg Am 60 (1978) 940-947
5. Oh I.K., Nomura N., and Hanada S. Mechanical properties of porous titanium compacts prepared by powder sintering. Scripta Mater 49 (2003) 1197-1202
6. Ryan G., Pandit A., and Apatsidis D.P. Fabrication methods of porous metals for use in orthopaedic applications. Biomaterials 27 (2006) 2651-2670
7. van Blitterswijk A., Grote J.J., Kuijpers W., Daems W.T., and de Groot K. Macropore tissue ingrowth: a quantitative and qualitative study on hydroxyapatite ceramic. Biomaterials 7 (1986) 137-143
8. Schliephake H., Neukam F.W., and Klosa D. Influence of pore dimensions on bone ingrowth into porous hydroxylapatite blocks used as bone graft substitutes. A histometric study. Int J Oral Maxillofac Surg 20 (1991) 53-58
9. Davis N.G., Teisen J., Schuh C., and Dunand D.C. Solid-state foaming of titanium by superplastic expansion of argon-filled pores. J Mater Res 16 (2001) 1508-1519
10. Li J.P., Li S.H., de Groot K., and Layrolle P. Preparation and characterization of porous titanium. Key Eng Mater 218 (2002) 51-54
11. Wen C.E., Mabuchi M., Yamada Y., Shimojima K., Chino Y., and Asahina T. Processing of biocompatible porous Ti and Mg. Scripta Mater 45 (2001) 1147-1153
12. Otsuki B., Takemoto M., Fujibayashi S., Neo M., Kokubo T., and Nakamura T. Pore throat size and connectivity determine bone and tissue ingrowth into porous implants: three-dimensional micro-CT based structural analyses of porous bioactive titanium implants. Biomaterials 27 (2006) 5892-5900
13. 4V scaffold directly fabricating by rapid prototyping: preparation and in vitro experiment. Biomaterials 27 (2006) 1223-1235
14. Li J.P., Habibovic P., van de Doel M., Wilson C.E., de Wijn J.R., van Blitterswijk C.A., et al. Bone ingrowth in porous titanium implants produced by 3D fiber deposition. Biomaterials 28 (2007) 2810-2820
15. Heinl P., Rottmair A., Körner C., and Singer R.F. Cellular titanium by selective electron beam melting. Adv Eng Mater 9 (2007) 360-364
16. Lemons J.E. Biomaterials, biomechanics, tissue healing, and immediate-function dental implants. J Oral Implantol 30 (2004) 318-324
17. Jonasova L., Müller F.A., Helebrant A., Strnad J., and Greil P. Biomimetic apatite formation on chemically treated titanium. Biomaterials 25 (2004) 1187-1194
18. Kokubo T. Formation of biologically active bone-like apatite on metals and polymers by a biomimetic process. Thermochim Acta 280/281 (1996) 479-490
19. Hanawa T., Kon M., Doi H., Ukai H., Murakami K., Hamanaka H., et al. Amounts of hydroxyl radical on calcium-ion-implanted titanium and point of zero charge of constituent oxide of the surface-modified layer. J Mat Sci: Mat Med 9 (1998) 89-92
20. 3- content and its influence on the composition of biomimetic apatites. Acta Biomater 2 (2006) 181-189
21. Sevilla P., Aparicio C., Planell J.A., and Gil F.J. Comparison of the mechanical properties between tantalum and nickel-titanium foams implant materials for bone ingrowth applications. J Alloys Compounds 439 (2007) 67-73
22. Reilly D.T., and Burstein A.H. The elastic and ultimate properties of compact bone tissue. J Biomech 8 (1975) 393-405
23. Cezayirlioglu H., Bahniuk E., Davy D.T., and Heiple K.G. Anisotropic yield behavior of bone under combined axial force and torque. J Biomech 18 (1985) 61-69
24. Gibson L.J., and Ashby M.F. Cellular solids - structure and properties. 2nd ed. (1997), Cambridge University Press, Cambridge p. 175-234
25. Currey J.D. Bone - structure and mechanics (2002), Princeton University Press, Princeton and Oxford p. 54-62
26. Bamberger C.A., and Begun G.M. Sodium titanates: stoichiometry and Raman spectra. J Am Ceram Soc 70 (1987) C-48-C-51
27. Becker I., Hofmann I., and Müller F.A. Preparation of bioactive sodium titanate ceramics. J Eur Cer Soc 27 (2007) 4547-4553
28. Koutsopoulus S. Synthesis and characterization of hydroxyapatite crystals: a review study on the analytical methods. J Biomed Mat Res 62 (2002) 600-612
29. Stoch A., Jastrzebski W., Brozek A., Stoch J., Szatraniec J., Trybalska B., et al. FTIR absorption-reflection study of biomimetic growth of phosphates on titanium implants. J Mol Struct 555 (2000) 375-382
30. Van Kemenade K.J.J.M., and de Bruyn P.L. A kinetic study of precipitation from supersaturated calcium phosphate solutions. J Colloid Interf Sci 118 (1987) 564-585
31. Zhu P., Masuda Y., Yonezawa T., and Koumoto K. Investigation of apatite deposition onto charged surfaces in aqueous solutions using a quartz-crystal microbalance. J Am Ceram Soc 86 (2003) 782-790