Heparin - A unique stimulator of human colon cancer cells' growth

IUBMB Life

Volumn 60, Issue 5, 2008, Pages 333-340

  Chatzinikolaou, Georgia ^a   Nikitovic, Dragana ^a   Asimakopoulou, Athanasia ^b   Tsatsakis, Aristidis ^a   Karamanos, Nikos K ^a   Tzanakakis, George N ^a  

^a UNIVERSITY OF CRETE   (Greece)

^b UNIVERSITY OF PATRAS   (Greece)

Author keywords

Colon cancer cell lines; Glycosaminoglycans; Heparin; Proteoglycans

Indexed keywords

CHONDROITIN SULFATE; DERMATAN SULFATE; FIBROBLAST GROWTH FACTOR 2; GLYCOSAMINOGLYCAN; GLYCOSIDASE; HEPARAN SULFATE; HEPARIN; HYALURONIC ACID; NEUTRALIZING ANTIBODY; PROTEOGLYCAN; FIBRINOLYTIC AGENT; FIBROBLAST GROWTH FACTOR RECEPTOR; MESSENGER RNA; SULFATE;

ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CELL PROLIFERATION; COLON CANCER; CONTROLLED STUDY; GLYCOSAMINOGLYCAN METABOLISM; HUMAN; HUMAN CELL; PROTEOGLYCAN SYNTHESIS; SULFATION; CELL CULTURE; COLON TUMOR; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; IMMUNOLOGY; METABOLISM; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

BLOTTING, WESTERN; CELL PROLIFERATION; CHONDROITIN SULFATES; COLONIC NEOPLASMS; DERMATAN SULFATE; FIBRINOLYTIC AGENTS; FIBROBLAST GROWTH FACTOR 2; HEPARIN; HEPARITIN SULFATE; HUMANS; HYALURONIC ACID; RECEPTORS, FIBROBLAST GROWTH FACTOR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SULFATES; TUMOR CELLS, CULTURED;

EID: 46749121510     PISSN: 15216543     EISSN: 15216551     Source Type: Journal    
DOI: 10.1002/iub.70     Document Type: Article

References (27)

1. Xu, R., Zhou, B., Fung, P. C., and Li, X. (2006) Recent advances in the treatment of colon cancer. Histol. Histopathol. 21, 867-872.
2. Lin, C. Q. and Bissell, M. J. (1993) Multi-faceted regulation of cell differentiation by extracellular matrix. Faseb J. 7, 737-743. (Pubitemid 23199531)
3. Aguiar, C. B., Lobao-Soares, B., Alvarez-Silva, M., and Trentin, A. G. (2005) Glycosaminoglycans modulate C6 glioma cell adhesion to extracellular matrix components and alter cell proliferation and cell migration. BMC Cell Biol. 6, 31-39.
4. Pupa, S. M., Menard, S., Forti, S., and Tagliabue, E. (2002) New insights into the role of extracellular matrix during tumor onset and progression. J. Cell Physiol. 192, 259-267. (Pubitemid 34827603)
5. Fjeldstad, K. and Kolset, S. O. (2005) Decreasing the metastatic potential in cancers - targeting the heparan sulfate proteoglycans. Curr. Drug Targets 6, 665-682. (Pubitemid 41236550)
6. Syrokou, A., Tzanakakis, G., Tsegenidis, T., Hjerpe, A., and Karamanos, N. K. (1999) Effects of glycosaminoglycans on proliferation of epithelial and fibroblast human malignant mesothelioma cells: a structure-function relationship. Cell Prolif. 32, 85-99. (Pubitemid 29488052)
7. Nikitovic, D., Zafiropoulos, A., Tzanakakis, G. N., Karamanos, N. K., and Tsatsakis, A. M. (2005) Effects of glycosaminoglycans on cell proliferation of normal osteoblasts and human osteosarcoma cells depend on their type and fine chemical compositions. Anticancer Res. 25, 2851-2856. (Pubitemid 41044672)
8. Nikitovic, D., Assouti, M., Sifaki, M., Katonis, P., Krasagakis, K., Karamanos, N. K., and Tzanakakis, G. N. (2008) Chondroitin sulfate and heparan sulfate-containing proteoglycans are both partners and targets of basic fibroblast growth factor-mediated proliferation in human metastatic melanoma cell lines. Int. J. Biochem. Cell Biol. 40, 72-83.
9. Fthenou, E., Zafiropoulos, A., Tsatsakis, A., Stathopoulos, A., Karamanos, N. K., and Tzanakakis, G. N. (2006) Chondroitin sulfate A chains enhance platelet-derived growth factor-mediated signalling in fibrosarcoma cells. Int. J. Biochem. Cell Biol. 38, 2141-2150.
10. Au, Y. P., Kenagy, R. D., Clowes, M. M., and Clowes, A. W. (1993) Mechanisms of inhibition by heparin of vascular smooth muscle cell proliferation and migration. Haemostasis 23(Suppl 1), 177-182. (Pubitemid 23116290)
11. Flint, N., Cove, F. L., and Evans, G. S. (1994) Heparin stimulates the proliferation of intestinal epithelial cells in primary culture. J. Cell Sci. 107(Pt 2), 401-411. (Pubitemid 24072873)
12. Fthenou, E., Zafiropoulos, A., Katonis, P., Tsatsakis, A., Karamanos, N. K., and Tzanakakis, G. N. (2007) Chondroitin sulfate prevents platelet derived growth factor-mediated phosphorylation of PDGF-Rβ in normal human fibroblasts severely impairing mitogenic responses. J. Cell. Biochem., in press.
13. Karamanos, N. K., Vanky, P., Tzanakakis, G. N., Tsegenidis, T., and Hjerpe, A. (1997) Ion-pair high-performance liquid chromatography for determining disaccharide composition in heparin and heparan sulphate. J. Chromatogr. A 765, 169-179. (Pubitemid 27152227)
14. Zigrino, P., Loffek, S., and Mauch, C. (2005) Tumor-stroma interactions: their role in the control of tumor cell invasion. Biochimie 87, 321-328. (Pubitemid 40387611)
15. Fannon, M. and Nugent, M.A. (1996) Basic fibroblast growth factor binds its receptors, is internalized, and stimulates DNA synthesis in Balb/c3T3 cells in the absence of heparin sulphate. J. Biol. Chem. 271, 17949-17956.
16. Denholm, E. M., Cauchon, E., Poulin, C., and Silver, P. J. (2000) Inhibition of human dermal fibroblast proliferation by removal of dermatan sulfate. Eur. J. Pharmacol. 400, 145-153.
17. Maurer, A. M., Han, Z. C., Dhermy, D., and Briere, J. (1994) Glycosaminoglycans enhance human leukemic cell growth in vitro. Leuk. Res. 18, 837-842.
18. Fishman, S., Brill, S., Papa, M., Halpern, Z., and Zvibel, I. (2002) Heparin-derived disaccharides modulate proliferation and Erb-B2-mediated signal transduction in colon cancer cell lines. Int. J. Cancer 99, 179-184. (Pubitemid 34309473)
19. Zvibel, I., Halpern, Z., and Papa, M. (1998) Extracellular matrix modulates expression of growth factors and growth-factor receptors in liver-colonizing colon-cancer cell lines. Int. J. Cancer 77, 295-301. (Pubitemid 28287984)
20. Vongchan, P., Warda, M., Toyoda, H., Toida, T., Marks, R. M., and Linhardt, R. J. (2005) Structural characterization of human liver heparan sulphate. Biochim. Biophys. Acta 1721, 1-8.
21. Molist, A., Romaris, M., Villena, J., and Bassols, A. (1997) Enterocytic differentiation correlates with changes in the fine structure and sulfation of perlecan in HT29 human colon carcinoma cells. Biochem. Biophys. Res. Commun. 238, 874-879.
22. Nugent, M. A. and Iozzo, R. V. (2000) Fibroblast growth factor-2. Int. J. Biochem. Cell Biol. 32, 115-120.
23. Netzer, P., Domek, M., Pai, R., Halter, F., and Tarnawski, A. (2001) Inhibition of human colon cancer cell growth by antisense oligodeoxynucleotides targeted at basic fibroblast growth factor. Aliment. Pharmacol. Ther. 15, 1673-1679.
24. Day, R., Ilyas, M., Daszak, P., Talbot, I., and Forbes, A. (1999) Expression of syndecan-1 in inflammatory bowel disease and a possible mechanism of heparin therapy. Dig. Dis. Sci. 44, 2508-2515.
25. Kurokawa, M., Doctrow, S. R., and Klagsbrun, M. (1989) Neutralizing antibodies inhibit the binding of basic fibroblast growth factor to its receptor but not to heparin. J. Biol. Chem. 264, 7686-7691.
26. Powell, A. K., Yates, E. A., Fernig, D. G., and Turnbull, J. E. (2004) Interactions of heparin/heparan sulfate with proteins: appraisal of structural factors and experimental approaches. Glycobiology 14, 17R-30R.
27. Taylor, K. R., and Gallo, R. L. (2006) Glycosaminoglycans and their proteoglycans: host-associated molecular patterns for initiation and modulation of inflammation. Faseb J. 20, 9-22.