Oxidative stress plays a permissive role in α2-adrenoceptor-mediated events in immortalized SHR proximal tubular epithelial cells

Molecular and Cellular Biochemistry

Volumn 315, Issue 1-2, 2008, Pages 31-39

  Simão, Sönia ^a   Fraga, Sónia ^a   Jose, Pedro A ^b   Soares da Silva, Patrício ^a  

^a Institute of Pharmacology and Therapeutics   (Portugal)

^b GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

2 Adrenoceptor; Adenylyl cyclase; Cl HCO3 exchanger; H2O2; Hypertension; SHR; WKY

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; ALPHA 2B ADRENERGIC RECEPTOR; APOCYNIN; BICARBONATE CHLORIDE ANTIPORTER; BRIMONIDINE; BUCLADESINE; CYCLIC AMP; FORSKOLIN; HYDROGEN PEROXIDE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PRAZOSIN; PROTEIN P22; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; YOHIMBINE;

ANIMAL CELL; ARTICLE; CELL IMMORTALIZATION; CONTROLLED STUDY; CORRELATION ANALYSIS; EPITHELIUM CELL; GENE OVEREXPRESSION; IMMUNOBLOTTING; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE EPITHELIUM; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT; RECEPTOR UPREGULATION; SPONTANEOUSLY HYPERTENSIVE RAT; WISTAR KYOTO RAT;

ACETOPHENONES; ACTINS; ANIMALS; BUCLADESINE; CELL LINE, TRANSFORMED; CHLORIDE-BICARBONATE ANTIPORTERS; EPITHELIAL CELLS; FORSKOLIN; HYDROGEN PEROXIDE; KIDNEY TUBULES, PROXIMAL; MEMBRANE GLYCOPROTEINS; NADPH OXIDASE; OXIDATIVE STRESS; PERTUSSIS TOXIN; QUINOXALINES; RATS; RATS, INBRED SHR; RECEPTORS, ADRENERGIC, ALPHA-2;

RATTUS;

EID: 46749111385     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-008-9785-6     Document Type: Article

References (42)

1. Guyton AC, Coleman TG, Cowley AV Jr, Scheel KW, Manning RD Jr, Norman RA Jr (1972) Arterial pressure regulation. Overriding dominance of the kidneys in long-term regulation and in hypertension. Am J Med 52:584-594. doi: 10.1016/0002-9343(72)90050-2
2. DiBona GF (2005) Physiology in perspective: The wisdom of the body. Neural control of the kidney. Am J Physiol Regul Integr Comp Physiol 289:R633-R641
3. Kanagy NL (2005) Alpha 2-adrenergic receptor signalling in hypertension. Clin Sci (Lond) 109:431-437
4. Gesek FA (1999) Alpha 1- and alpha 2-adrenoceptor control of sodium transport reverses in developing hypertension. Hypertension 33:524-529
5. Rossier BC, Palmer LG (1992) Mechanisms of aldosterone action on sodium and potassium transport. In: Seldin DW (ed) The kidney, physiology and pathophysiology. Raven Press Publishers, New York, pp 1373-1409
6. Verrey F (1995) Transcriptional control of sodium transport in tight epithelial by adrenal steroids. J Membr Biol 144:93-110
7. Aronson PS, Giebisch G (1997) Mechanisms of chloride transport in the proximal tubule. Am J Physiol Renal Physiol 273:F179-F192
8. - symport in the sheep cardiac Purkinje fibre. J Physiol 451:365-385
9. + exchanger. Am J Physiol Regul Integr Comp Physiol 281:R10-R18
10. Lazdunski M, Frelin C, Vigne P (1985) The sodium/hydrogen exchange system in cardiac cells: Its biochemical and pharmacological properties and its role in regulating internal concentrations of sodium and internal pH. J Mol Cell Cardiol 17:1029-1042
11. - exchange mediates recovery of pHi from alkalosis in guinea pig ventricular myocytes. Am J Physiol 267:H85-H91
12. 3 transport in the renal proximal tubule. J Membr Biol 131:1-10
13. +exchangers in health and disease processes. J Investig Med 43:419-430
14. Alpern RJ (1990) Cell mechanisms of proximal tubule acidification. Physiol Rev 70:79-114
15. - cotransporter. Pflugers Arch 440:713-20
16. - exchanger in rat kidney proximal tubule. Am J Physiol Cell Physiol 285:C608-C617
17. - cotransporter in health and disease processes. Kidney Int 57:371-384
18. - exchanger in immortalized SHR proximal tubular epithelial cells. Am J Physiol Renal Physiol 286:F1120-F1126
19. 2 leads to hypertension. Hypertension 42:25-30
20. Minuz P, Patrignani P, Gaino S, Degan M, Menapace L, Tommasoli R, Seta F, Capone ML, Tacconelli S, Palatresi S, Bencini C, Del Vecchio C, Mansueto G, Arosio E, Santonastaso CL, Lechi A, Morganti A, Patrono C (2002) Increased oxidative stress and platelet activation in patients with hypertension and renovascular disease. Circulation 106:2800-2805
21. Schnackenberg CG, Welch WJ, Wilcox CS (1998) Normalization of blood pressure and renal vascular resistance in SHR with a membrane-permeable superoxide dismutase mimetic: Role of nitric oxide. Hypertension 32:59-64
22. Vaziri ND, Ni Z, Oveisi F, Trnavsky-Hobbs DL (2000) Effect of antioxidant therapy on blood pressure and NO synthase expression in hypertensive rats. Hypertension 36:957-964
23. Adler S, Huang H (2004) Oxidant stress in kidneys of spontaneously hypertensive rats involves both oxidase overexpression and loss of extracellular superoxide dismutase. Am J Physiol Renal Physiol 287:F907-F913
24. de Cavanagh EM, Toblli JE, Ferder L, Piotrkowski B, Stella I, Inserra F (2006) Renal mitochondrial dysfunction in spontaneously hypertensive rats is attenuated by losartan but not by amlodipine. Am J Physiol Regul Integr Comp Physiol 290:R1616-R1625
25. Sullivan JC, Sasser JM, Pollock JS (2006) Sexual Dimorphism in oxidant status in spontaneously hypertensive rats. Am J Physiol Regul Integr Comp Physiol 292:R764-R768
26. Woost PG, Orosz DE, Jin W, Frisa PS, Jacobberger JW, Douglas JG, Hopfer U (1996) Immortalization and characterization of proximal tubule cells derived from kidneys of spontaneously hypertensive and normotensive rats. Kidney Int 50:125-134
27. 1-like receptor function in two opossum kidney cell clonal sublines. Cell Physiol Biochem 12:259-268
28. Thomas JA, Buchsbaum RN, Zimniak A, Racker E (1979) Intracellular pH measurements in Ehrlich ascites tumor cells utilizing spectroscopic probes generated in situ. Biochemistry 18:2210-2218
29. - exchanger activity in rat intestinal epithelial IEC-6 cells is regulated by G protein-coupled receptor kinase 6 (GRK 6). Cell Physiol Biochem 18:347-360
30. Yingst DR, Massey KJ, Rossi NF, Mohanty MJ, Mattingly RR (2004) Angiotensin II directly stimulates activity and alters the phosphorylation of Na-K-ATPase in rat proximal tubule with a rapid time course. Am J Physiol Renal Physiol 287:F713-F721
31. + exchanger. Am J Physiol 258:F514-F521
32. + exchanger. Am J Physiol 258:F636-F642
33. Bedard K, Krause KH (2007) The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology. Physiol Rev 87:245-313
34. Anand-Srivastava MB (1993) Platelets from spontaneously hypertensive rats exhibit decreased expression of inhibitory guanine nucleotide regulatory protein. Relation with adenylyl cyclase activity. Circ Res 73:1032-1039
35. Brodde OE, Michel MC (1992) Adrenergic receptors and their signal transduction mechanisms in hypertension. J Hypertens Suppl 10:S133-S145
36. Khalid M, Ilhami N, Giudicelli Y, Dausse JP (2002) Testosterone dependence of salt-induced hypertension in Sabra rats and role of renal alpha 2-adrenoceptor subtypes. J Pharmacol Exp Ther 300:43-49
37. Stanko CK, Smyth DD (1991) Proximal tubular alpha 2-adrenoceptor density in the spontaneously hypertensive rat. Am J Hypertens 4:64-67
38. Umemura S, Marver D, Smyth DD, Pettinger WA (1985) Alpha 2-adrenoceptors and cellular cAMP levels in single nephron segments from the rat. Am J Physiol Renal Fluid Electrolyte Physiol 249:F28-F33
39. Murphy TJ, Bylund DB (1988) Characterization of alpha 2-adrenergic receptors in the OK cell, an opossum kidney cell line. J Pharmacol Exp Ther 244:571-578
40. 1-like receptors from G proteins via a mechanism involving protein kinase C and G-protein-coupled receptor kinase 2. Free Radic Biol Med 40:13-20
41. Chabrashvili T, Tojo A, Onozato ML, Kitiyakara C, Quinn MT, Fujita T, Welch WJ, Wilcox CS (2002) Expression and cellular localization of classic NADPH oxidase subunits in the spontaneously hypertensive rat kidney. Hypertension 39:269-274
42. Zhan CD, Sindhu RK, Vaziri ND (2004) Up-regulation of kidney NAD(P)H oxidase and calcineurin in SHR: Reversal by lifelong antioxidant supplementation. Kidney Int 65:219-227