Activation of subthalamic nucleus outflow by high-frequency stimulation is consistent with the nigral control of epilepsy model

Stereotactic and Functional Neurosurgery

Volumn 86, Issue 4, 2008, Pages 216-218

  Gross, Robert E ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; MUSCIMOL;

BRAIN DEPTH STIMULATION; EPILEPSY; FREQUENCY MODULATION; GLOBUS PALLIDUS; HUMAN; NONHUMAN; NOTE; SUBSTANTIA NIGRA; SUBTHALAMIC NUCLEUS;

ANIMALS; DEEP BRAIN STIMULATION; DISEASE MODELS, ANIMAL; EPILEPSY; HUMANS; SUBSTANTIA NIGRA; SUBTHALAMUS;

EID: 46749093821     PISSN: 10116125     EISSN: None     Source Type: Journal    
DOI: 10.1159/000131658     Document Type: Note

References (17)

1. Zhang B, Chu J, Zhang J, Ma Y: Change of extracellular glutamate and gamma-aminobutyric acid in substantia nigra and globus pallidus during electrical stimulation of subthalamic nucleus in epileptic rats. Stereotact Funct Neurosurg 2008;86:208-215.
2. Iadarola MJ, Gale K: Substantia nigra: site of anticonvulsant activity mediated by gamma-aminobutyric acid. Science 1982;218:1237-1240.
3. Garant DS, Gale K: Lesions of substantia nigra protect against experimentally induced seizures. Brain Res 1983;273:156-161.
4. Deransart C, Marescaux C, Depaulis A: Involvement of nigral glutamatergic inputs in the control of seizures in a genetic model of absence epilepsy in the rat. Neuroscience 1996;71:721-728.
5. Piredda S, Gale K: A crucial epileptogenic site in the deep prepiriform cortex. Nature 1985;317:623-625.
6. Garant D, Gale K: Intranigral muscimol attenuates electrographic signs of seizure activity induced by intravenous bicuculline in rats. Eur J Pharmacol 1986;124:365-369.
7. Vercueil L, Benazzouz A, Deransart C, Bressand K, Marescaux C, Depaulis A, Benabid AL: High-frequency stimulation of the subthalamic nucleus suppresses absence seizures in the rat: comparison with neurotoxic lesions. Epilepsy Res 1998;31:39-46.
8. Chabardes S, Kahane P, Minotti L, Koudsie A, Hirsch E, Benabid AL: Deep brain stimulation in epilepsy with particular reference to the subthalamic nucleus. Epileptic Disord 2002;4(suppl 3):S83-S93.
9. Dinner DS, Neme S, Nair D, Montgomery EB Jr, Baker KB, Rezai A, Luders HO: EEG and evoked potential recording from the subthalamic nucleus for deep brain stimulation of intractable epilepsy. Clin Neurophysiol 2002;113:1391-1402.
10. Perlmutter JS, Mink JW: Deep brain stimulation. Annu Rev Neurosci 2006;29:229-257.
11. Hahn PJ, Russo GS, Hashimoto T, Miocinovic S, Xu W, McIntyre CC, Vitek JL: Pallidal burst activity during therapeutic deep brain stimulation. Exp Neurol 2008, in press.
12. Hashimoto T, Elder CM, Okun MS, Patrick SK, Vitek JL: Stimulation of the subthalamic nucleus changes the firing pattern of pallidal neurons. J Neurosci 2003;23:1916-1923.
13. Van der Kooy D, Hattori T: Single subthalamic nucleus neurons project to both the globus pallidus and substantia nigra in rat. J Comp Neurol 1980;192:751-768.
14. Delfs JM, Ciaramitaro VM, Parry TJ, Chesselet MF: Subthalamic nucleus lesions: widespread effects on changes in gene expression induced by nigrostriatal dopamine depletion in rats. J Neurosci 1995;15:6562-6575.
15. Benazzouz A, Tai CH, Meissner W, Bioulac B, Bezard E, Gross C: High-frequency stimulation of both zona incerta and subthalamic nucleus induces a similar normalization of basal ganglia metabolic activity in experimental parkinsonism. Faseb J 2004;18:528-530.
16. Tai CH, Boraud T, Bezard E, Bioulac B, Gross C, Benazzouz A: Electrophysiological and metabolic evidence that high-frequency stimulation of the subthalamic nucleus bridles neuronal activity in the subthalamic nucleus and the substantia nigra reticulata. Faseb J 2003;17:1820-1830.
17. Kita H, Kitai ST: The morphology of globus pallidus projection neurons in the rat: an intracellular staining study. Brain Res 1994;636:308-319.