Mean nuclear area and metallothionein expression in ductal breast tumors: Correlation with estrogen receptor status

Applied Immunohistochemistry and Molecular Morphology

Volumn 16, Issue 2, 2008, Pages 108-112

  El Sharkawy, Sonia L ^a   Farrag, Abdel Razik H ^a  

^a NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

Breast tumors; Estrogen receptor; Mean nuclear area; Metallothionein

Indexed keywords

ESTROGEN RECEPTOR; METALLOTHIONEIN;

ARTICLE; BREAST; BREAST CARCINOMA; BREAST FIBROADENOMA; CANCER CELL; CONTROLLED STUDY; CORRELATIONAL STUDY; HISTOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; INTRADUCTAL CARCINOMA; MAJOR CLINICAL STUDY; MEAN NUCLEAR AREA MEASUREMENT; MEASUREMENT; MYOEPITHELIUM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; BREAST TUMOR; CELL NUCLEUS; CHEMISTRY; FEMALE; FIBROADENOMA; IMMUNOHISTOCHEMISTRY; PAGET NIPPLE DISEASE; PATHOLOGY;

BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; CARCINOMA, INTRADUCTAL, NONINFILTRATING; CELL NUCLEUS; FEMALE; FIBROADENOMA; HUMANS; IMMUNOHISTOCHEMISTRY; METALLOTHIONEIN; RECEPTORS, ESTROGEN;

EID: 46749092140     PISSN: 15412016     EISSN: 15334058     Source Type: Journal    
DOI: 10.1097/PAI.0b013e31806d9b88     Document Type: Article

References (30)

1. Giardina C, Serio G, Lepore G, et al. Pure ductal carcinoma in situ and in situ component of ductal invasive carcinoma of the breast. A preliminary morphometric study. J Exp Clin Cancer Res. 2003;22: 279-288.
2. Milliken EL, Amduri RK, Landis MD, et al. Ovarian hyperstimulation by LH leads to mammary gland hyperplasia and cancer predisposition in transgenic mice. Endocrinology. 2002;143: 3671-3680.
3. Rothman C, Bashack I, Gil A, et al. Potential use of spectral image analysis for the quantitative evaluation of estrogen receptors in breast cancer. Histol Histopathol. 2000;15:1051-1057.
4. Surowiak P, Paluchowski P, Wysocka T, et al. Steroid receptor status, proliferation and metallothionein expression in primary invasive ductal breast cancers. Pathol Oncol Res. 2004;10:207-211.
5. Lee H, Douglas-Jones AG, Morgan JM, et al. The effect of fixation and processing on the sensitivity of estrogen receptor assay by immunohistochemistry in breast carcinoma. J Clin Pathol. 2002;55: 236-238.
6. Canzonieri V, Monfardini S, Carbone A. Defining prognostic factors in malignancies through image analysis. Eur J Cancer. 1998;34:451-458.
7. Hytiroglou P, Harpaza N, Heller DS. Differential diagnosis of borderline and invasive serous cystadenocarcinomas of the ovary by computerized interactive morphometric analysis of nuclear features. Cancer. 1992;69:988-992.
8. Mulder JWR, Offerhaus GJA, De Feyter EP. The relationship of quantitative nuclear morphology to molecular genetic alteration in the adenoma-carcinoma sequence of the large bowel. Am J Pathol. 1992;141:797-804.
9. Kruger S, Muller S. Correlation of morphometry, nuclear organizer regions, proliferating cell nuclear antigen and Ki-67 antigen expression with grading and staging in urinary bladder carcinomas. Br J Urol. 1995;75:480-484.
10. Ruiz A, Almenar S, Callghan RC, et al. Benign, preinvasive and invasive ductal breast lesions. A comparative study with quantitative techniques: morphometry, image- and flow cytometry. Pathol Res Pract. 1999;195:741-746.
11. Jin R, Chow VTK, Tan PH, et al. Metallothionein 2A expression is associated with cell proliferation in breast cancer. Carcinogenesis. 2003;23:81.
12. Fresno M, Wu W, Rodriguez JM, et al. Localization of metallothionein in breast carcinomas. An immunohistochemical study. Virchows Arch Pathol Anat Histopathol. 1993;423:215.
13. Bloom HJG, Richardson WW. Histopathological grading and prognosis in breast cancer. Br J Cancer. 1957;11:359-377.
14. Wilson RE. The breast. In: Sabiston DC, ed. Textbook of Surgery: The Biologic Basis of Modern Surgical Practice. 13th ed. London, Philadelphia, Toronto: WB Saunders Co Ltd; 1986:530-572.
15. Somji S, Sens MA, Lam DL, et al. Metallothionein isoform 1 and 2 gene expression in the human bladder: evidence for upregulation of MT-1X mRNA in bladder cancer. Cancer Detect Preven. 2001; 25:62-75.
16. Naglaa FA, Nabila SH. Immunohistochemical detection of epidermal growth factor receptor (EGFR) and transforming growth factor alpha (TGF-a) in benign and malignant epithelial tumours of human breast: correlation with estrogen receptor status. J Egypt Soc Path. 2002;22:431-438.
17. Ikeguchi M, Cai J, Oka S, et al. Nuclear profiles of cancer cells reveal the metastatic potential of gastric cancer. J Pathol. 2000;192: 19-25.
18. Nafe R, Fritch RS, Soadah B, et al. Histomorphometry in paraffin sections of thyroid tumours. Pathol Res Prac. 1992;188: 1042-1048.
19. Tan PH, Goh BB, Chiang G, et al. Correlation of nuclear morphometry with pathologic parameters in ductal carcinoma in situ of the breast. Mod Pathol. 2001;14:937-941.
20. Sarker SK. Mean nuclear area of fine needle aspirates of primary preoperative palpable breast carcinoma using image cytometry. Anal-Quant-Cytol-Histol. 2002;24:85-88.
21. Elzagheid A, Collan Y. Fine needle aspiration biopsy of the breast. Value of nuclear morphometry after different sampling methods. Annal-Quant-Cytol- Histol. 2003;25:73-80.
22. Tan Y, Sinniah R, Bay BH, et al. Expression of metallothionein and nuclear size in discrimination of malignancy in mucinous ovarian tumours. Int J Gynecol Pathol. 1999;18:344-350.
23. Abbas NF, Abbas EA, Abdel Aal WE. Image cytometric analysis of mean nuclear area and nuclear organizer regions (AgNORs) in oral squamous cell carcinoma. Egypt Med J NRC. 2002;1: 141-157.
24. Maiorana A, Cavallari V, Bagni A, et al. Nuclear area in breast cancer: relation with estrogen and progesterone receptor expression. Anal-Cell-Pathol. 1996;11:199-209.
25. Jasani B, Campbell F, Navabi H, et al. Clonal overexpression of metallothionein is induced by somatic mutation in morphologically normal colonic mucosa. J Pathol. 1998;184:144-147.
26. Fuentealba IC, Mullins JE. Immunohistochemical demonstration of metallothionein in benign and malignant canine mammary tumours. Histol Histopathol. 1999;14:51-61.
27. Zhang R, Zhang H, Wei H, et al. Expression of metallothionein in invasive ductal breast cancer in relation to prognosis. J Environ Pathol Toxicol Oncol. 2000;19:95-97.
28. Jin R, Bay BH, Chow VTK, et al. Significance of metallothionein expression in breast myoepithelial cells. Cell Tissue Res. 2001;303: 221-226.
29. Oyama T, Take H, Hikino T, et al. Immunohistochemical expression of metallothionein in invasive breast cancer in relation to proliferative activity, histology and prognosis. Oncology. 1996;53: 112-117.
30. Fan LZ, Cherian MG. Potential role of P53 on metallothionein induction in human epithelial breast cancer cells. Br J Cancer. 2002; 87:1019-1026.