The peripheral serotonergic pathway: A new target for treating erectile dysfunction?

American Journal of Men's Health

Volumn 2, Issue 1, 2008, Pages 37-39

  Lau, David H W ^a   Thompson, Cecil S ^a   Mikhailidis, Dimitri P ^a,b  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b ROYAL FREE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; PHOSPHODIESTERASE INHIBITOR; SEROTONIN RECEPTOR;

ARTICLE; BLOOD; DRUG DELIVERY SYSTEM; DRUG EFFECT; ERECTILE DYSFUNCTION; FORECASTING; HUMAN; MALE; METABOLISM; PATHOPHYSIOLOGY; SENSITIVITY AND SPECIFICITY; SIGNAL TRANSDUCTION;

DRUG DELIVERY SYSTEMS; ENZYME INHIBITORS; ERECTILE DYSFUNCTION; FORECASTING; HUMANS; MALE; PHOSPHODIESTERASE INHIBITORS; RECEPTORS, SEROTONIN; SENSITIVITY AND SPECIFICITY; SIGNAL TRANSDUCTION;

EID: 46649107321     PISSN: 15579883     EISSN: 15579891     Source Type: Journal    
DOI: 10.1177/1557988307308612     Document Type: Article

References (24)

1. Ahlenius, S., Larsson, K., & Arvidsson, L.E. (1989). Effects of stereoselective 5-HT1A agonists on male rat sexual behavior. Pharmacology, Biochemistry, and Behavior, 33, 691-695.
2. Ahn, G.J., Kang, K.K., Kim, D.S., Ahn, B.O., Kim, W.B., Kang, S.K., et al. (2005). DA-8159 reverses selective serotonin reuptake inhibitor-induced erectile dysfunction in rats. Urology, 65, 202-207.
3. Angulo, J., Peiro, C., Sanchez-Ferrer, C.F., Gabancho, S., Cuevas, P., Gupta, S., et al. (2001). Differential effects of serotonin reuptake inhibitors on erectile responses, NO-production, and neuronal NO synthase expression in rat corpus cavernosum tissue. British Journal of Pharmacology, 134, 1190-1194.
4. Bancila, M., Giuliano, F., Rampin, O., Mailly, P., Brisorgueil, M.J., Calas, A., et al. (2002). Evidence for a direct projection from the paraventricular nucleus of the hypothalamus to putative serotoninergic neurons of the nucleus paragigantocellularis involved in the control of erection in rats. European Journal of Neuroscience, 16, 1240-1248.
5. Bancila, M., Verge, D., Rampin, O., Backstrom, J.R., Sanders-Bush, E., McKenna, K.E., et al. (1999). 5-Hydroxytryptamine 2C receptors on spinal neurons controlling penile erection in the rat. Neuroscience, 92, 1523-1537.
6. Barradas, M.A., Gill, D.S., Fonseca, V.A., Mikhailidis, D.P., & Dandona, P. (1988). Intraplatelet serotonin in patients with diabetes mellitus and peripheral vascular disease. European Journal of Clinical Investigation, 18, 399-404.
7. Brotto, L.A., & Gorzalka, B.B. (2000). Melatonin enhances sexual behavior in the male rat. Physiology and Behavior, 68, 483-486.
8. Esen, A.A., Gidener, S., Guler, C., Guven, H., & Kirkali, Z. (1997). Contractility changes of the deep dorsal penile vein due to serotonin. Journal of Urology, 158, 234-237.
9. Finberg, J.P., & Vardi, Y. (1990). Inhibitory effect of 5-Hydroxytryptamine on penile erectile function in the rat. British Journal of Pharmacology, 101, 698-702.
10. Furukawa, K., Nagao, K., Ishii, N., & Uchiyama, T. (2003). Responses to serotonin (5HT) in isolated corpus cavernosum penis of rabbit. International Journal of Impotence Research, 15, 267-271.
11. Giuliano, F. (2007). 5-Hydroxytryptamine in premature ejaculation: Opportunities for therapeutic intervention. Trends in Neuroscience, 30, 79-84.
12. Hayes, E.S., & Adaikan, P.G. (2002). The effects of 5HT(1) agonists on erection in rats in vivo and rabbit corpus cavernosum in vitro. International Journal of Impotence Research, 14, 205-212.
13. Hull, E.M., Muschamp, J.W., & Sato, S. (2004). Dopamine and serotonin: Influences on male sexual behavior. Physiology and Behavior, 8, 291-307.
14. Kimura, Y., Naitou, Y., Wanibuchi, F., & Yamaguchi, T. (2006). Characterization of intracavernous pressure increase induced by Ym348, a novel 5-HT2C receptor agonist, in anesthetized rats. Journal of Urology, 175, 1953-1957.
15. Lau, D.H., Thompson, C.S., Bellringer, J.F., Thomas, P.J., Mumtaz, F.H., Morgan, R.J., et al. (2006). Doxazosin and serotonin (5-HT) receptor (1A, 2A, and 4) antagonists inhibit 5-HT-mediated human cavernosal contraction. Journal of Andrology, 27, 679-685.
16. Lau, D.H.W., Thompson, C.S., Mumtaz, F.H., Morgan, R.J., & Mikhailidis, D.P. (in press). Serotonin induces a biphasic response in rabbit cavernosal smooth muscle: Relevance to the erectile process. Urologia Internationalis, 79.
17. Martin, G.R., & Humphrey, P.P. (1994). Receptors for 5-Hydroxytryptamine: Current perspectives on classification and nomenclature. Neuropharmacology, 33, 261-273.
18. Myrick, H., Markowitz, J.S., & Henderson, S. (1998). Priapism following trazodone overdose with cocaine use. Annals of Clinical Psychology, 10, 81-83.
19. Rehman, J., Kaynan, A., Christ, G., Valcic, M., Maayani, S., & Melman, A. (1999). Modification of sexual behavior of Long-Evans male rats by drugs acting on the 5-HT1A receptor. Brain Research, 821, 414-425.
20. Rothman, R.B., & Baumann, M.H. (2002). Serotonin releasing agents: neurochemical, therapeutic and adverse effects. Pharmacology, Biochemistry, and Behavior, 7, 825-836.
21. Steers, W.D. (1990). Neural control of penile erection. Seminars in Urology, 8, 66-79.
22. Uckert, S., Fuhlenriede, M.H., Becker, A.J., Stief, C.G., Scheller, F., Knapp, W.H., et al. (2003). Is serotonin significant for the control of penile flaccidity and detumescence in the human male ? Urological Research, 31, 55-60.
23. Vrentzos, G.E., Paraskevas, K.I., & Mikhailidis, D.P. (2007). Dyslipidemia as a risk factor for erectile dysfunction. Current Medicinal Chemistry, 14, 1689-1699.
24. Waldinger, M.D. (2007). Premature ejaculation: Definition and drug treatment. Drug, 67, 547-568.