Prostacyclin analogs stimulate receptor-mediated cAMP synthesis and ATP release from rabbit and human erythrocytes

Microcirculation

Volumn 15, Issue 5, 2008, Pages 461-471

  Sprague, Randy S ^a   Bowles, Elizabeth ^a   Hanson, Madelyn ^a   Dufaux, Eileen ^a   Sridharan, Meera ^a   Adderley, Shaquria ^a   Ellsworth, Mary ^a   Stephenson, Alan ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adenosine triphosphate; Adenylyl cyclase; Iloprost; Red blood cell; UT 15C

Indexed keywords

ADENOSINE TRIPHOSPHATE; CAY 10441; CYCLIC AMP; ILOPROST; PROSTACYCLIN DERIVATIVE; PROSTACYCLIN RECEPTOR; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; UNIPROST; UT 15C;

ADULT; ANIMAL CELL; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ERYTHROCYTE; EXPERIMENTAL RABBIT; HUMAN; HUMAN CELL; MALE; NONHUMAN; PHOSPHATE METABOLISM; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN LOCALIZATION; VASODILATATION; WESTERN BLOTTING;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANTIHYPERTENSIVE AGENTS; CYCLIC AMP; EPOPROSTENOL; ERYTHROCYTES; HUMANS; ILOPROST; RABBITS; RECEPTORS, PROSTAGLANDIN; VASODILATION; VASODILATOR AGENTS;

ORYCTOLAGUS CUNICULUS;

EID: 46449108922     PISSN: 10739688     EISSN: 15498719     Source Type: Journal    
DOI: 10.1080/10739680701833804     Document Type: Article

References (50)

1. Aronoff, D., Peres, C., Serezani, C., Ballinger, M., Carstens, J., Coleman, N., Moore, B., Peebles, R., Faccioli, L. and Peters-Golden, M. (2007) Synthetic prostacyclin analogues differentially regulate macrophage function via distinct analog-receptor binding specificities. J Immonol, 178, pp. 1628-1634.
2. Barst, R., Rubin, L., McGoon, M., Caldwell, E., Long, W. and Levy, P. (1994) Survival in primary pulmonary hypertension with long-term continuous intravenous prostacyclin. Ann Intern Med, 121, pp. 409-415.
3. Bergfeld, G. and Forrester, T. (1992) Release of ATP from human erythrocytes in response to a brief period of hypoxia and hypercapnea. Cardiovasc Res, 26, pp. 40-47.
4. Brown, I., Thompson, C. and Belloni, F. (1992) Mechanisms of coronary vasodilation produced by ATP in guinea-pig isolated perfused heart. Br J Pharmacol, 105, pp. 211-215.
5. Collins, D., McCullough, W. and Ellsworth, M. (1998) Conducted vascular responses: Communication across the capillary bed. Microvasc Res, 56, pp. 43-53.
6. Conte, J., Gaine, S., Orens, J., Harris, T. and Rubin, L. (1998) The influence of continuous prostacyclin therapy for primary pulmonary hypertension on the timing and outcome of transplantation. J Heart Lung Transpl, 17, pp. 679-685.
7. Clapp, L., Finney, P., Turcato, S., Tran, S., Rubin, L. and Tinker, A. (2002) Differential effects of stable prostacyclin analogues on smooth muscle proliferation and cyclic AMP generation in human pulmonary artery. Am J Respir Cell Mol Biol, 26, pp. 194-201.
8. Clark, R., Jahangir, A., Severance, D., Salazar, R., Chang, T., Chang, D., Jett, M., Smith, S. and Bley, K. (2004) Discovery and SAR development of 2-(phenolamino) imidazolines as prostacyclin receptor antagonists. Bioorg Med Chem Lett, 14, pp. 1053-1056.
9. Dietrich, H., Ellsworth, M., Sprague, R. and Dacey, R. (2000) Red blood cell regulation of microvascular tone through adenosine triphosphate. Am J Physiol, 278, pp. H1294-H1298.
10. Dutta-Roy, A., Hoque, L. and Paterson, B. (1993) Prostaglandin-E1-binding sites in rabbit erythrocyte membranes. Eur J Biochem, 213, pp. 1167-1173.
11. Dutta-Roy, A. and Sinha, A. (1985) Binding of prostaglandin E1 to human erythrocyte membranes. Biochim Biophys Acta, 812, pp. 671-678.
12. Ellsworth, M., Forrester, T., Ellis, C. and Dietrich, H. (1995) The erythrocyte as a regulator of vascular tone. A J Physiol, 269, pp. H2155-H2161.
13. Ellsworth, M. (2000) The red blood cell as an oxygen sensor: What is the evidence?. Acta Physiol Scand, 168, pp. 551-559.
14. Fetalvero, K., Martin, K. and Hwa, J. (2007) Cardioprotective prostacyclin signaling in vascular smooth muscle. Prostagland Lipid Mediat, 82, pp. 109-118.
15. Forsberg, E., Feuerstein, G., Shohami, E. and Pollard, H. (1987) Adenosine triphosphate stimulates inositol phospholipid metabolism and prostacyclin formation in adrenal medullary endothelial cells by means of P2-purinergic receptors. Proc Natl Acad Sci USA, 84, pp. 5630-5634.
16. Higgenbottam, T., Butt, A., Dinh-Xuan, A., Takao, M., Cremona, G. and Akamine, S. (1998) Treatment of pulmonary hypertension with the continuous infusion of a prostacyclin analogue, iloprost. Heart, 79, pp. 175-179.
17. Higgenbottam, T., Butt, Y., McMahon, A., Westerbeck, R. and Sharples, L. (1998) Long term intravenous prostaglandin (epoprostenol or iloprost) for treatment of severe pulmonary hypertension. Heart, 80, pp. 151-155.
18. Houston, D., Burnstock, G. and Vanhoutte, P. (2001) Different P2-purinergic receptor subtypes of endothelium and smooth muscle in canine blood vessels. J Pharmacol Exp Ther, 241, pp. 501-506.
19. 2delivery mediated by hemoglobin oxygenation. Am J Physiol Heart Circ Physiol, 280, pp. H2833-H2839.
20. Kaestner, L., Tabellion, W., Lipp, P. and Bernhardt, I. (2004) Prostaglandin E2 activates channel-mediated calcium entry into human erythrocytes: An indication for a blood clot formation supporting process. Thromb Haemost, 92, pp. 1269-1272.
21. Kaneko, F., Arroliga, A., Dweik, R., Comhair, S., Laskowski, D., Oppedisano, R., Thomassen, M. and Erzurum, S. (1998) Biochemical reaction products of nitric oxide as quantitative markers of primary pulmonary hypertension. Am J Respir Crit Care Med, 158, pp. 917-923.
22. Kennedy, C., Delbro, D. and Burnstock, G. (1985) P2-purinoceptors mediate both vasodilation (via the endothelium) and vasoconstriction of the isolated rat femoral artery. Eur J Pharmacol, 1072, pp. 161-168.
23. Korbut, R., Adamek-Guzik, T., Madej, J. and Korbut, R. (2002) Endothelial secretagogues and deformability of erythrocytes. J Physiol Pharmacol, 53, pp. 655-665.
24. Kovacs, I. and O'Grady, J. (1984) Prostacyclin increases filterability of normal and rigidified human red blood cells in vitro. Agents Actions, 14, pp. 306-310.
25. Kiriyama, M., Ushikubi, F., Kobayashi, T., Hirata, M., Sugimoto, Y. and Narumiya, S. (1997) Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol, 122, pp. 217-224.
26. Kukovetz, W., Holtzmann, S., Wurm, A. and Poch, G. (1979) Prostacyclin increases cAMP in coronary arteries. J Cyclic Nucleotide Res, 5, pp. 469-476.
27. Kuniciki, T. and Newman, P. (1992) The molecular immunology of human platelet proteins. Blood, 80, pp. 1386-1404.
28. Laliberte, K., Arneson, C., Jeffs, R., Hunt, T. and Wade, M. (2004) Pharmacokinetics and steady-state bioequivalence of treprostinil sodium (Remodulin®) administered by the intravenous and subcutaneous route to normal volunteers. J Cardiovasc Pharmacol, 44, pp. 209-214.
29. + channel in human erythrocytes and alters cell volume and filterability. J Biol Chem, 271, pp. 18651-18656.
30. McLaughlin, V., Gaine, S., Barst, R., Oudiz, R., Bourge, R., Frost, A., Robbins, I., Tapson, V., McGoon, M., Badesch, D., Sigman, J., Roscigno, R., Blackburn, S., Arneson, C., Rubin, L., Rich, S. and the Treprostinil Study Group (2003) Efficacy and safety of treprostinil: An epoprostenol analog for primary pulmonary hypertension. J Cardiovasc Pharm, 41, pp. 293-299.
31. 2+ levels in human erythrocytes. Biochem Biophys Acta, 1220, pp. 31-36.
32. McCullough, W., Collins, D. and Ellsworth, M. (1997) Arteriolar responses to extracellular ATP in striated muscle. Am J Physiol, 272, pp. H1886-H1891.
33. Moroi, M. and Jung, S. (1998) Integrin-mediated platelet adhesion. Front Bioscience, 3, pp. 719-728.
34. Motte, S., Pirotton, S. and Boeynaems, J. (1993) Heterogeneity of ATP receptors in aortic endothelial cells: Involvement of P2y and P2u receptors in inositol phosphate response. Circ Res, 72, pp. 504-510.
35. Nakagawa, M., Willner, J., Cerri, C. and Reydel, P. (1984) The effect of membrane preparation and cellular maturation on human erythrocyte adenylate cyclase. Biochem Biophys Acta, 770, pp. 122-126.
36. Narumiya, S., Sugimoto, Y. and Fumitaka, U. (1999) Prostanoid receptors: structures, properties, and functions. Pharmacol Rev, 70, pp. 1193-1219.
37. Olearczyk, J., Ellsworth, M., Stephenson, A., Lonigro, A. and Sprague, R. (2004) Nitric oxide inhibits ATP release from erythrocytes. J Pharmacol Exp Ther, 309, pp. 1079-1084.
38. Olearczyk, J., Stephenson, A., Lonigro, A. and Sprague, R. (2001) Receptor-mediated activation of the heterotrimeric G-protein Gs results in ATP release from erythrocytes. Med Sci Monit, 7, pp. 669-674.
39. Olearczyk, J., Stephenson, A., Lonigro, A. and Sprague, R. (2004) Heterotrimeric G protein Gi is involved in a signal transduction pathway for ATP release from erythrocytes. Am J Physiol, 286, pp. H940-H945.
40. Ozkan, M., Dweik, R., Laskowski, D., Arroliga, A. and Erzurum, S. (2002) High levels of nitric oxide in individuals with pulmonary hypertension receiving epoprostenol therapy. Lung, 179, pp. 233-243.
41. Sager, G. (1982) Receptor binding sites for beta-adrenergic ligands on human erythrocytes. Biochem Pharmacol, 31, pp. 99-104.
42. Sprague, R., Bowles, E., Stumpf, M., Ricketts, G., Friedman, A., Hou, W-H, Stephenson, A. and Lonigro, A. (2005) Rabbit erythrocytes possess adenylyl cyclase type II that is activated by the heterotrimeric G proteins Gs and Gi. Pharmacol Rep, 57, pp. 222-228.
43. Sprague, R., Ellsworth, M., Stephenson, A., Kleinhenz, M. and Lonigro, A. (1998) Deformation-induced ATP release from red blood cells requires cystic fibrosis transmembrane conductance regulator activity. Am J Physiol, 275, pp. H1726-H1732.
44. Sprague, R., Ellsworth, M., Stephenson, A. and Lonigro, A. (1996) ATP: the red blood cell link to NO and local control of the pulmonary circulation. Am J Physiol, 271, pp. H2717-H2722.
45. Sprague, R., Ellsworth, M., Stephenson, A. and Lonigro, A. (2001) Participation of cAMP in a signal-transduction pathway relating erythrocyte deformation of ATP release. Am J Physiol, 281, pp. C1158-C1164.
46. Sprague, R., Olearczyk, J., Spence, D., Stephenson, A., Sprung, R. and Lonigro, A. (2003) Extracellular ATP signaling in the rabbit lung: erythrocytes as determinants of vascular resistance. Am J Physiol, 285, pp. H693-H700.
47. Sprague, R., Stephenson, A., Bowles, E., Stumpf, S. and Lonigro, A. (2006) Reduced expression of Gi in erythrocytes of humans with diabetes type 2 is associated with impairment of both cAMP generation and ATP release. Diabetes, 55, pp. 3588-3593.
48. Sprague, R., Stephenson, A., Ellsworth, M., Keller, C. and Lonigro, A. (2001) Impaired release of ATP from red blood cells of humans with primary pulmonary hypertension. Exp Biol Med, 226, pp. 434-439.
49. Tateson, J., Moncada, S. and Vane, J. (1977) Effects of prostacyclin (PGX) on cyclic AMP concentration in human platelets. Prostaglandins, 13, pp. 389-397.
50. Willems, C., Stel, H., van Aken, W. and van Mourik, J. (1983) Binding and inactivation of prostacyclin (PGI2) by human erythrocytes. Br J Haematol, 54, pp. 43-52.